【摘要】：在高強(qiáng)度聚焦超聲治療腫瘤問題的研究中,高強(qiáng)度聚焦超聲(high-intensity focused ultrasound,HIFU)治療大血管周邊的肝腫瘤時(shí),血流對(duì)HIFU形成可治療焦域的影響難以預(yù)測(cè)和實(shí)時(shí)監(jiān)控,可能導(dǎo)致腫瘤組織殘留或者血管的損傷等臨床治療問題。為了預(yù)測(cè)大血管對(duì)HIFU肝腫瘤治療的影響,以HIFU治療血管周邊腫瘤為例建立三維仿真模型,利用Westervelt聲傳播方程及Pennes生物熱傳導(dǎo)方程,用時(shí)域有限差分法數(shù)值仿真HIFU治療形成的溫度場(chǎng)。仿真結(jié)果表明,當(dāng)大血管位于目標(biāo)治療區(qū)域附近時(shí),血管位置對(duì)60℃以上可治療焦域的形狀、大小及位置均有顯著影響,但血流速度的影響很小。而當(dāng)血管位于目標(biāo)治療區(qū)域內(nèi)部時(shí),血流速度對(duì)可治療焦域的影響不可忽略。上述研究結(jié)果可為HIFU實(shí)際臨床治療提供理論數(shù)據(jù)和參考依據(jù)。
[Abstract]:In the study of high intensity focused ultrasound (HIFU) in the treatment of liver tumors around large vessels, the effect of blood flow on the formation of focal areas is difficult to predict and monitor in real time. May lead to tumor tissue residues or vascular injury and other clinical treatment problems. In order to predict the effect of large blood vessels on the treatment of HIFU liver tumors, a three-dimensional simulation model was established by using the Westervelt acoustic propagation equation and Pennes biothermic conduction equation. The temperature field of HIFU was numerically simulated by finite difference time domain (FDTD) method. The simulation results show that when the large blood vessel is located near the target therapeutic area, the position of the vessel has a significant effect on the shape, size and location of the treatable focal region above 60 鈩，

本文編號(hào)：2119570