紅細胞分布寬度在急性腦梗死動脈硬化評估中的應用
[Abstract]:Objective to investigate the correlation between red blood cell distribution width (RDW) and carotid intima-media thickness (IMT) and risk factors of arteriosclerosis in patients with acute cerebral infarction (ACI). Methods A case-control study was conducted in 133 inpatients with acute cerebral infarction and 30 healthy controls. According to the RDWquartile, the patients with acute cerebral infarction were divided into the lowest quartile group (n = 34), the low quartile group (n = 45) and the high quartile group (n = 24). The highest quartile group included 30 cases. The clinical data and risk factors of cerebrovascular disease were collected, fasting blood glucose, blood lipid, glycosylated hemoglobin, mean RDW, mean red blood cell volume (MCV) and so on were measured, and the intima-media thickness of neck vessel was measured by ultrasound. Blood flow velocity and other indicators. Results in the acute cerebral infarction group, compared with the control group, the, RDW (P0. 001) and the intima-media thickness of the internal carotid artery (P < 0. 008) were significantly different. There were statistical differences in the indexes of each group of acute cerebral infarction, homocysteine (P0. 04), and the other indexes had no statistical significance. The correlation analysis showed that RDW was correlated with diastolic blood pressure (P = 0.012), homocysteine (P = 0.004), glycosylated hemoglobin (P = 0.031), carotid intima-media thickness (IMT) and white blood cell count (P = 0.024), lymphocyte count (P = 0.008). There was a positive correlation between fibrinogen (P < 0. 039). Conclusion there is a positive correlation between RDW and arteriosclerosis-related risk factors (diastolic blood pressure, glycosylated hemoglobin, homocysteine) in elderly patients with cerebral infarction. Among the four groups of acute cerebral infarction, with the increase of RDW and IMT, the degree of arteriosclerosis increased, but there was no significant difference.
【作者單位】: 山東大學附屬濟南市中心醫(yī)院;
【基金】:國家自然科學基金資助項目(No.81373635) 濟南市科技發(fā)展國際合作項目(201212012)
【分類號】:R743.33
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