尋常型銀屑病合并代謝綜合征患者血清脂肪因子Chemerin的臨床研究
發(fā)布時(shí)間：2019-06-01 22:12
【摘要】：目的:通過(guò)研究尋常型銀屑病合并代謝綜合征(MS)患者血清脂肪因子Chemerin的水平變化及相關(guān)因素,探討尋常型銀屑病與MS的關(guān)系及其可能的發(fā)病機(jī)制。方法:本研究共納入研究對(duì)象115例,其中PSMS組(銀屑病合并代謝綜合征組)30例,PS組(銀屑病組)30例,MS組(代謝綜合征組)30例,NC組(健康對(duì)照組)25例。用酶聯(lián)免疫吸附測(cè)定(ELISA)實(shí)驗(yàn)檢測(cè)所有研究對(duì)象的血清Chemerin水平進(jìn)行各組間比較,同時(shí)對(duì)各組研究對(duì)象身高、體重、腰圍(WC)、收縮壓(SBP)、舒張壓(DBP)、甘油三酯(TG)、總膽固醇(TC)、低密度脂蛋白膽固醇(LDL-C)、高密度脂蛋白膽固醇(HDL-C)、空腹血糖(FPG)、空腹胰島素(Fins)、超敏C反應(yīng)蛋白(hs-CRP)、白介素-6(IL-6)濃度進(jìn)行檢測(cè),計(jì)算身體質(zhì)量指數(shù)(BMI)、胰島素抵抗指數(shù)(HOMA-IR),對(duì)于所有銀屑病患者,追加調(diào)查PASI評(píng)分(銀屑病面積與嚴(yán)重程度指數(shù))、病程、初次發(fā)病年齡、煙酒史、用藥史、家族史,將部分指標(biāo)與血清脂肪因子Chemerin進(jìn)行相關(guān)性分析。所有結(jié)果應(yīng)用SPSS16.0進(jìn)行相關(guān)統(tǒng)計(jì)學(xué)分析。結(jié)果:1.PSMS組、PS組、MS組血清Chemerin水平均高于NC組,其中又以PSMS組最高,差異有統(tǒng)計(jì)學(xué)意義(P0.05)；2.血清hs-CRP、IL-6水平PSMS組、PS組、MS組均高于NC組,且以PSMS組最高,差異有統(tǒng)計(jì)學(xué)意義(P0.05)；3.PSMS組、PS組、MS組BMI、WC、SBP、Fins、HOMA-IR、TG、TC、LDL-C水平均明顯高于NC組(P0.05)；PSMS組WC、Fins、HOMA-IR、LDL-C水平高于單純MS組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)；4.PSMS組中MS各組分分布以腹型肥胖最多,其余依次為高TG、高血壓、低HDL-C、高血糖；MS組MS各組分分布以高血壓最多,其次為腹型肥胖、高TG、高血糖、低HDL-C；5.PSMS組與PS組比較,煙酒史、用藥史、家族史無(wú)明顯差異,但其PASI評(píng)分較PS組明顯升高；6.PSMS組血清Chemerin水平與BMI(r=0.369)、WC(r=0.428)、TG(r=0.482)、LDL-C(r=0.371)、hs-CRP(r=0.519)、IL-6(r=0.575)、PASI(r=0.372),具有線性正相關(guān)關(guān)系(P0.05),與SBP、DBP、HOMA-IR、TC、HDL-C無(wú)明顯相關(guān)性(P0.05)；7.以血清Chemerin濃度作為因變量,以BMI、WC、TG、LDL-C、hs-CRP、IL-6及PASI作為自變量作多元逐步回歸分析顯示hs-CRP、IL-6、WC、TG進(jìn)入回歸方程,其中對(duì)Chemerin影響最大的是IL-6(β=0.352),其次是hs-CRP(β=0.302)。結(jié)論:1.Chemerin主要通過(guò)參與炎癥參與并影響尋常型銀屑病合并MS的發(fā)病及進(jìn)展,并且其血清水平與患者肥胖、脂代謝紊亂、炎癥及銀屑病嚴(yán)重程度密切相關(guān)；2.尋常型銀屑病患者及MS患者均處于一定程度的炎癥狀態(tài),又以二者并發(fā)時(shí)炎癥程度最高；3.尋常型銀屑病患者中存在代謝紊亂情況；尋常型銀屑病可加重MS患者腹型肥胖、胰島素抵抗與脂代謝紊亂程度,MS也可以增加尋常型銀屑病患者病情的嚴(yán)重程度。
[Abstract]:Objective: to study the changes and related factors of serum fat factor Chemerin in patients with psoriasis vulgaris complicated with metabolic syndrome (MS), and to explore the relationship between psoriasis vulgaris and MS and its possible pathogenesis. Methods: a total of 115 cases were included in this study, including 30 cases in PSMS group (psoriasis complicated with metabolic syndrome group), 30 cases in PS group (psoriatic group), 30 cases in MS group (metabolic syndrome group) and 25 cases in NC group (healthy control group). The serum Chemerin levels of all subjects were measured by enzyme-linked immunosorbent assay (ELISA). At the same time, the height, weight and waist circumference (WC), systolic blood pressure of (SBP), diastolic blood pressure (DBP), were compared. TG (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), fasting blood glucose (FPG), fasting insulin (Fins), high sensitive C reactive protein (hs-CRP), The concentration of IL-6 (IL-6) was measured, the body mass index (BMI),) insulin resistance index (HOMA-IR) was calculated, and the PASI score (psoriasis area and severity index) and course of disease were investigated in all patients with psoriasis. The age of first onset, the history of tobacco and alcohol, the history of drug use and the family history were analyzed to analyze the correlation between some indexes and serum fat factor Chemerin. All the results were analyzed by SPSS16.0. Results: the serum Chemerin levels in 1.PSMS group, PS group and MS group were higher than those in NC group, and PSMS group was the highest, the difference was statistically significant (P 0.05). The level of serum hs-CRP,IL-6 in PSMS group, PS group and MS group was higher than that in NC group, and PSMS group was the highest, the difference was statistically significant (P 0.05). The levels of BMI,WC,SBP,Fins,HOMA-IR,TG,TC,LDL-C in 3.PSMS group, PS group and MS group were significantly higher than those in NC group (P 0.05). The level of WC,Fins,HOMA-IR,LDL-C in PSMS group was significantly higher than that in MS group (P 0.05). The distribution of MS in 4.PSMS group was the most in abdominal obesity, followed by high TG, hypertension and low HDL-C, hyperglycemia. The distribution of MS components in MS group was hypertension, followed by abdominal obesity, high TG, and hyperglycemia. Compared with PS group, there was no significant difference in tobacco and alcohol history, drug use history and family history between low HDL-C;5.PSMS group and PS group, but the PASI score was significantly higher than that in PS group. Serum Chemerin levels were correlated with BMI (r 鈮，
本文編號(hào)：2490626
[Abstract]:Objective: to study the changes and related factors of serum fat factor Chemerin in patients with psoriasis vulgaris complicated with metabolic syndrome (MS), and to explore the relationship between psoriasis vulgaris and MS and its possible pathogenesis. Methods: a total of 115 cases were included in this study, including 30 cases in PSMS group (psoriasis complicated with metabolic syndrome group), 30 cases in PS group (psoriatic group), 30 cases in MS group (metabolic syndrome group) and 25 cases in NC group (healthy control group). The serum Chemerin levels of all subjects were measured by enzyme-linked immunosorbent assay (ELISA). At the same time, the height, weight and waist circumference (WC), systolic blood pressure of (SBP), diastolic blood pressure (DBP), were compared. TG (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), fasting blood glucose (FPG), fasting insulin (Fins), high sensitive C reactive protein (hs-CRP), The concentration of IL-6 (IL-6) was measured, the body mass index (BMI),) insulin resistance index (HOMA-IR) was calculated, and the PASI score (psoriasis area and severity index) and course of disease were investigated in all patients with psoriasis. The age of first onset, the history of tobacco and alcohol, the history of drug use and the family history were analyzed to analyze the correlation between some indexes and serum fat factor Chemerin. All the results were analyzed by SPSS16.0. Results: the serum Chemerin levels in 1.PSMS group, PS group and MS group were higher than those in NC group, and PSMS group was the highest, the difference was statistically significant (P 0.05). The level of serum hs-CRP,IL-6 in PSMS group, PS group and MS group was higher than that in NC group, and PSMS group was the highest, the difference was statistically significant (P 0.05). The levels of BMI,WC,SBP,Fins,HOMA-IR,TG,TC,LDL-C in 3.PSMS group, PS group and MS group were significantly higher than those in NC group (P 0.05). The level of WC,Fins,HOMA-IR,LDL-C in PSMS group was significantly higher than that in MS group (P 0.05). The distribution of MS in 4.PSMS group was the most in abdominal obesity, followed by high TG, hypertension and low HDL-C, hyperglycemia. The distribution of MS components in MS group was hypertension, followed by abdominal obesity, high TG, and hyperglycemia. Compared with PS group, there was no significant difference in tobacco and alcohol history, drug use history and family history between low HDL-C;5.PSMS group and PS group, but the PASI score was significantly higher than that in PS group. Serum Chemerin levels were correlated with BMI (r 鈮，
本文編號(hào)：2490626
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