千金文武湯聯(lián)合二甲雙胍治療太陰人2型糖尿病的臨床研究
發(fā)布時間：2019-05-29 18:27
【摘要】：目的:通過朝醫(yī)方"千金文武湯"聯(lián)合二甲雙胍(Metformin)對太陰人2型糖尿病(Type 2 Diabetes Mellitus,T2DM)(氣陰兩虛型)的治療結(jié)果進行分析,觀察臨床療效,評價朝醫(yī)藥治療太陰人2型糖尿病的有效性和臨床價值,為朝醫(yī)方治療糖尿病提供有效的科學依據(jù)。方法:將2015年3月至2016年12月期間,在延吉市中醫(yī)醫(yī)院和延邊朝醫(yī)醫(yī)院門診及住院部到訪患者中,收集辨象為太陰人且患有2型糖尿病的患者60例,將其隨機分為治療組和對照組,各30例,兩組均給予基礎治療(糖尿病知識教育;個體化的營養(yǎng)治療;運動療法)。對照組在基礎治療上口服鹽酸二甲雙胍片,0.5g/次,日2次;治療組在對照組治療基礎上給予千金文武湯(葛根15g、山藥15g、藁本15g、黃芩15g、五味子10g、麥門冬15g、桔梗10g、升麻10g、白芷10g)治療。水煎400ml,200ml/次,日1劑。3周為1個療程,連續(xù)觀察3個療程。藥物治療前先觀察患者的中醫(yī)癥狀,記癥狀積分,檢查并記錄餐后2小時血糖(2hPG)、空腹血糖(FPG)、糖化血紅蛋白(HbAlc)、甘油三酯(TG)、總膽固醇(TC),作為治療前的有效數(shù)據(jù)。藥物治療結(jié)束后,觀察治療組與對照組各患者的癥狀變化,給相應的癥狀積分,分別記錄治療后的各項指標,最后統(tǒng)計治療前后的FPG、2hPG、HbAlc、TG、TC(HDL-C;LDL-C)等生化指標的變化情況。得到數(shù)據(jù)以均數(shù)士標準差(x±S)表示,數(shù)據(jù)處理采用SPSS17.0中進行分析。結(jié)果:治療組明顯改善中醫(yī)臨床癥狀,優(yōu)于對照組(P0.05)。兩組均能降低血糖(FPG;2hPG),降低HbAlc,千金文武湯組比對照組的療效更高(P0.05)。治療組有效調(diào)節(jié)血脂異常,降低血脂指標,P0.05,對照組明顯改善甘油三酯(TG),其余無統(tǒng)計學意義。調(diào)節(jié)TG方面,千金文武湯組優(yōu)于對照組。結(jié)論:朝醫(yī)方"千金文武湯"聯(lián)合二甲雙胍(Metformin)治療太陰人2型糖尿病(T2DM)療效明顯,具有一定的治療作用�？梢愿纳芓2DM患者的臨床癥狀,降低血糖(FPG;2hPG),調(diào)節(jié)血脂、總膽固醇(HDL-C;LDL-C),比單純用二甲雙胍(Metformin)藥物治療更有優(yōu)勢。
[Abstract]:Objective: to analyze the therapeutic effect of "Qianjin Wenwu decoction" combined with metformin (Metformin) on type 2 diabetes mellitus (Type 2 Diabetes Mellitus,T2DM) in Taiyin people (deficiency of both qi and yin), and to observe the clinical effect. To evaluate the effectiveness and clinical value of Korean medicine in the treatment of type 2 diabetes mellitus in Taiyin people, and to provide an effective scientific basis for the treatment of diabetes mellitus with Korean medicine prescription. Methods: from March 2015 to December 2016, 60 patients identified as Taiyin and suffering from type 2 diabetes mellitus were collected from the outpatient and inpatient departments of Yanji City Hospital of traditional Chinese Medicine and Yanbian Chaoyi Hospital. The patients were randomly divided into treatment group (n = 30) and control group (n = 30). Both groups were given basic treatment (diabetes knowledge education). Individualized nutritional therapy; exercise therapy. The control group was treated with metformin hydrochloride tablets, 0.5g/ twice a day. On the basis of treatment in the control group, the treatment group was treated with Qianjin Wenwu decoction (Pueraria lobata 15g, yam 15g, ligusticum 15g, Scutellaria baicalensis Georgi 15g, Schisandra chinensis 10g, Ophiopogon miltiorrhiza 15g, Platycodon grandiflorum 10g, Gastrodia elata 10g, Angelica dahurica 10g). Water decoction 400 ml, 200 ml / time, 1 dose a day. 3 weeks as a course of treatment, continuous observation of 3 courses of treatment. Before drug treatment, the symptoms of the patients were observed, the symptom scores were recorded, and the postmeal blood glucose (2hPG) and fasting blood glucose (FPG), glycosylated hemoglobin (HbAlc), glycerol (TG), total cholesterol (TC), were examined and recorded. As a valid data before treatment. After drug treatment, the changes of symptoms in the treatment group and the control group were observed, the corresponding symptom scores were given, the indexes after treatment were recorded, and the FPG,2hPG,HbAlc,TG,TC (HDL-C;) before and after treatment was counted. The changes of biochemical indexes such as LDL-C). The obtained data are represented by mean standard deviation (x 鹵S), and the data processing is analyzed by SPSS17.0. Results: the treatment group significantly improved the clinical symptoms of traditional Chinese medicine, better than the control group (P 0.05). Both groups could reduce blood glucose (FPG;2hPG), HbAlc, Qianjin Wenwu decoction group was more effective than the control group (P 0.05). The treatment group effectively regulated dyslipidemia and decreased the blood lipid index, P0.05, but the control group significantly improved the rest of TG (TG),. In regulating TG, Qianjin Wenwu decoction group was superior to the control group. Conclusion: Chaoyi recipe "Qianjin Wenwu decoction" combined with metformin (Metformin) is effective in the treatment of type 2 diabetes mellitus (T2DM) in patients with Taiyin. It can improve the clinical symptoms, reduce blood glucose (FPG;2hPG), regulate blood lipid and total cholesterol (HDL-C;LDL-C) in T2DM patients, which is more superior to metformin (Metformin) alone.
【學位授予單位】：延邊大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R587.1
，
本文編號：2488128
[Abstract]:Objective: to analyze the therapeutic effect of "Qianjin Wenwu decoction" combined with metformin (Metformin) on type 2 diabetes mellitus (Type 2 Diabetes Mellitus,T2DM) in Taiyin people (deficiency of both qi and yin), and to observe the clinical effect. To evaluate the effectiveness and clinical value of Korean medicine in the treatment of type 2 diabetes mellitus in Taiyin people, and to provide an effective scientific basis for the treatment of diabetes mellitus with Korean medicine prescription. Methods: from March 2015 to December 2016, 60 patients identified as Taiyin and suffering from type 2 diabetes mellitus were collected from the outpatient and inpatient departments of Yanji City Hospital of traditional Chinese Medicine and Yanbian Chaoyi Hospital. The patients were randomly divided into treatment group (n = 30) and control group (n = 30). Both groups were given basic treatment (diabetes knowledge education). Individualized nutritional therapy; exercise therapy. The control group was treated with metformin hydrochloride tablets, 0.5g/ twice a day. On the basis of treatment in the control group, the treatment group was treated with Qianjin Wenwu decoction (Pueraria lobata 15g, yam 15g, ligusticum 15g, Scutellaria baicalensis Georgi 15g, Schisandra chinensis 10g, Ophiopogon miltiorrhiza 15g, Platycodon grandiflorum 10g, Gastrodia elata 10g, Angelica dahurica 10g). Water decoction 400 ml, 200 ml / time, 1 dose a day. 3 weeks as a course of treatment, continuous observation of 3 courses of treatment. Before drug treatment, the symptoms of the patients were observed, the symptom scores were recorded, and the postmeal blood glucose (2hPG) and fasting blood glucose (FPG), glycosylated hemoglobin (HbAlc), glycerol (TG), total cholesterol (TC), were examined and recorded. As a valid data before treatment. After drug treatment, the changes of symptoms in the treatment group and the control group were observed, the corresponding symptom scores were given, the indexes after treatment were recorded, and the FPG,2hPG,HbAlc,TG,TC (HDL-C;) before and after treatment was counted. The changes of biochemical indexes such as LDL-C). The obtained data are represented by mean standard deviation (x 鹵S), and the data processing is analyzed by SPSS17.0. Results: the treatment group significantly improved the clinical symptoms of traditional Chinese medicine, better than the control group (P 0.05). Both groups could reduce blood glucose (FPG;2hPG), HbAlc, Qianjin Wenwu decoction group was more effective than the control group (P 0.05). The treatment group effectively regulated dyslipidemia and decreased the blood lipid index, P0.05, but the control group significantly improved the rest of TG (TG),. In regulating TG, Qianjin Wenwu decoction group was superior to the control group. Conclusion: Chaoyi recipe "Qianjin Wenwu decoction" combined with metformin (Metformin) is effective in the treatment of type 2 diabetes mellitus (T2DM) in patients with Taiyin. It can improve the clinical symptoms, reduce blood glucose (FPG;2hPG), regulate blood lipid and total cholesterol (HDL-C;LDL-C) in T2DM patients, which is more superior to metformin (Metformin) alone.
【學位授予單位】：延邊大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R587.1
，
本文編號：2488128
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