發(fā)布時間：2019-05-19 16:45

【摘要】：目的探討抵抗素與老年2型糖尿病(T2DM)及其心血管病的關(guān)系。方法選擇60例老年T2DM患者并測定抵抗素水平,患者年齡62~66歲,糖尿病平均病程為(10.2±2.4)年,在24個月的隨訪中,記錄致死性心血管病和非致死性心血管病事件,多因素Cox回歸分析心血管病的發(fā)病風(fēng)險。結(jié)果根據(jù)患者血清抵抗素中位值293.25 pg/ml進行分組,結(jié)果顯示性別分布、糖尿病病程、胰島素治療、體重指數(shù)(BMI)、生化結(jié)果和既往心血管事件均無顯著差異。在24個月的隨訪中,6例(10.00%)老年T2DM患者死于心血管疾病,14例(23.33%)發(fā)生了一次非致死性心血管病。血清抵抗素水平≥293.25 pg/ml組在致死性和非致死性心血管病變的聯(lián)合終點發(fā)生率明顯增高(P=0.001)。多因素Cox回歸分析顯示,抵抗素水平≥中位值者在聯(lián)合終點事件的發(fā)生風(fēng)險明顯增高(HR:5.73,95%CI:1.91~17.23)。結(jié)論根據(jù)抵抗素水平可評估老年T2DM的預(yù)后,對老年T2DM患者心血管病的危險分層提供依據(jù)。
[Abstract]:Objective to investigate the relationship between resistin and type 2 diabetes mellitus (T2DM) and cardiovascular disease in the elderly. Methods 60 elderly patients with T2DM were selected and resistin levels were measured. The average course of diabetes mellitus was (10.2 鹵2.4) years. The events of fatal cardiovascular disease and non-fatal cardiovascular disease were recorded during 24 months follow-up. Multivariate Cox regression analysis was used to analyze the risk of cardiovascular disease. Results the patients were divided into two groups according to the median serum resistin value of 293.25 pg/ml. The results showed that there were no significant differences in sex distribution, course of diabetes, insulin treatment, body mass index (BMI),) biochemical results and previous cardiovascular events. During the 24-month follow-up, 6 (10.00%) elderly patients with T2DM died of cardiovascular disease and 14 (23.33%) developed non-fatal cardiovascular disease. The incidence of combined end point of fatal and non-fatal cardiovascular disease was significantly increased in patients with serum resistin level 鈮，

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