糖脈康顆粒聯(lián)合阿侖膦酸鈉片治療糖尿病合并骨質(zhì)疏松癥的臨床研究
發(fā)布時間：2019-03-27 12:36
【摘要】：目的探討糖尿病與骨質(zhì)疏松癥的關(guān)系,加強對糖尿病合并骨質(zhì)疏松癥的認識,通過臨床觀察糖脈康顆粒聯(lián)合阿侖膦酸鈉片治療2型糖尿病合并骨質(zhì)疏松癥患者的客觀指標評價其臨床療效及安全性,為臨床應(yīng)用提供客觀依據(jù),更好服務(wù)于臨床。方法選取2012年10月至2014年3月期間于就診于武漢市中西結(jié)合醫(yī)院內(nèi)分泌科門診及住院部的2型糖尿病合并骨質(zhì)疏松癥的患者,按照納入條件選取60例,隨機分為兩組,分別為對照組和觀察組。在飲食、運動的基礎(chǔ)治療和糖尿病常規(guī)降糖治療的基礎(chǔ)上,對照組給予阿侖膦酸鈉片(石家莊制藥集團歐意藥業(yè)有限公司),每日一片(10mg),早晨空腹口服,治療組在觀察組的基礎(chǔ)上加用糖脈康顆粒(成都中匯制藥有限公司),每日三次,1次1包(5 g)。兩組在治療期間均補充維生素和鈣劑。兩組均連續(xù)服用6個月。觀察兩組治療前后中醫(yī)臨床癥狀積分,空腹血糖(FPG),餐后血糖(2h PG),糖化血紅蛋白(Hb A1c),骨密度測定(BMD)等進行統(tǒng)計分析。將所得數(shù)據(jù)應(yīng)用SPSS17.0統(tǒng)計軟件進行統(tǒng)計學(xué)分析,其中多組間的數(shù)據(jù)兩兩比較用t檢驗,療效的百分率的比較用χ2檢驗。此外,監(jiān)測患者血、尿、糞及肝腎功能等常規(guī)指標,了解藥物的安全性。結(jié)果①兩組剔除率比較:對照組與觀察組均未出現(xiàn)剔除情況,表明糖脈康顆粒為中藥濃縮顆粒沖劑,服用方便,使患者具有良好的依從性。②中醫(yī)癥狀臨床積分比較:治療前兩組患者在癥狀和體征的總積分上均無顯著性差異(P0.05),治療后兩組癥候總積分均改善(P0.05)。同時應(yīng)用尼莫地平法對各個中醫(yī)癥候療效比較發(fā)現(xiàn),觀察組患者在倦怠乏力、氣短懶言、口干喜飲、手足心熱、自汗盜汗、舌苔脈象癥狀上得到明顯改善,總有效率大于對照組,差異有非常顯著性統(tǒng)計學(xué)意義(P0.01),在腰膝酸軟、腰背疼痛上也較對照組改善明顯,有顯著性差異(P0.05)。③骨密度值的比較:治療前兩組骨密度值無明顯差異(P0.05),治療后兩組較治療前有顯著性差異(P0.05),同時對照組與觀察組比較也顯著性差異(P0.05)。④血糖值的比較:治療前兩組在空腹血糖、餐后血糖、糖化血紅蛋白均無顯著性差異(P0.05),治療后兩組血糖水平較治療前均有明顯改善,FPG、2h PG、Hb A1c較治療前有顯著性差異(P0.05),但兩組間治療后比較無顯著性差異(P0.05),提示患者血糖均得到有效控制,但兩組降糖效果相近。⑤不良反應(yīng)監(jiān)測情況的比較:兩組患者治療前后血常規(guī)、肝功能和腎功能均無明顯異常。對照組出現(xiàn)上腹部不適1例,但可耐受,觀察組未見明顯不適,兩組均未見嚴重不良反應(yīng)發(fā)生。結(jié)論通過本研究發(fā)現(xiàn)應(yīng)用糖脈康顆粒聯(lián)合阿侖膦酸鈉片治療糖尿病合并骨質(zhì)疏松癥的不僅能顯著改善患者中醫(yī)癥候,而且可以提高骨密度,控制血糖水平。同時糖脈康顆粒是傳統(tǒng)中藥濃縮顆粒沖劑,具有服用方便的優(yōu)點,并且無明顯的不良反應(yīng)和毒副作用,在糖尿病合并骨質(zhì)疏松癥患者中值得推廣。
[Abstract]:Objective To study the relationship between diabetes and osteoporosis and to strengthen the understanding of diabetes and osteoporosis. Provides an objective basis for clinical application and better service for clinical application. Methods From October,2012 to March,2014, the patients with type 2 diabetes and osteoporosis who were treated in the Department of the Endocrinology Department of Wuhan and the Chinese and Western combined hospital and the residents were randomly divided into two groups according to the conditions of inclusion, and the control group and the observation group were randomly divided into two groups. On the basis of the basic treatment of diet and exercise and the conventional blood sugar-lowering treatment of diabetes, the control group was given an Alphalan sodium tablet (Shijiazhuang Pharmaceutical Group, Oyi Pharmaceutical Co., Ltd.), one tablet daily (10 mg), and oral in the morning. On the basis of the observation group, the treatment group was treated with Tanggukang granule (Chengdu Zhonghui Pharmaceutical Co., Ltd.) three times a day and 1 bag (5 g). Both groups were supplemented with vitamins and calcium in the course of the treatment. The two groups were taken for 6 months. The clinical symptoms, fasting blood glucose (FPG), postprandial blood sugar (2h PG), glycosylated hemoglobin (Hb), bone mineral density (BMD), and the like of the two groups before and after treatment were statistically analyzed. Statistical analysis of the obtained data was carried out using the SPSS17.0 statistical software. The data between the multiple groups were compared with t-test, and the percentage of the curative effect was compared with the other two. In addition, routine indexes such as blood, urine, feces and liver and kidney function of the patient are monitored to understand the safety of the medicine. Results Compared with the two groups, the control group and the observation group had no rejection, which indicated that the sugar-pulse-kang granule is a traditional Chinese medicine concentrated granule, which is convenient to take, and the patient has good compliance. There was no significant difference in the total scores of symptoms and signs in the first two groups (P0.05), and the total score of the two groups was improved after treatment (P0.05). At the same time, the curative effect of the nimodipine on the symptoms of various Chinese medicine is found, and the patients in the observation group have a marked improvement in the symptoms of listlessness, fatigue, short-time, dry-mouth and dry-up, hand-and-foot-heart heat, spontaneous perspiration and night sweat, and tongue and tongue coating, and the total effective rate is greater than that of the control group. The difference was significant (P0.01). There was a significant difference in the soft and back pain of the waist and knees (P0.05). The values of bone mineral density in the two groups were not significant (P0.05). There was a significant difference between the two groups after the treatment (P0.05), and the control group and the observation group were significantly different (P0.05). The results showed that the two groups had no significant difference in fasting blood glucose, postprandial blood glucose and glycosylated hemoglobin (P0.05). After treatment, the blood glucose levels in the two groups were significantly improved, and the FPG, 2h PG and Hb were significantly different before the treatment (P0.05). However, there was no significant difference between the two groups (P0.05). Comparison of the monitoring of the adverse reaction of the two groups: the blood routine, the liver function and the renal function were not obvious before and after the treatment of the two groups. The abdominal discomfort in the control group was 1 case, but it was tolerated. No obvious discomfort was found in the observation group, and no serious adverse reaction occurred in the two groups. Conclusion It is found that by this study, the combined treatment of diabetes and osteoporosis with the combination of Tanggukang granule and Alphalan sodium tablets not only can obviously improve the symptoms of the traditional Chinese medicine, but also can improve the bone mineral density and control the blood sugar level. At the same time, the sugar-pulse-kang granule is a traditional Chinese medicine concentrated granule, which has the advantages of convenient administration, no obvious adverse reaction and toxic and side effects, and is worthy of popularization in the patients with diabetes and osteoporosis.
【學(xué)位授予單位】：湖北中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R587.1;R580
本文編號：2448185
[Abstract]:Objective To study the relationship between diabetes and osteoporosis and to strengthen the understanding of diabetes and osteoporosis. Provides an objective basis for clinical application and better service for clinical application. Methods From October,2012 to March,2014, the patients with type 2 diabetes and osteoporosis who were treated in the Department of the Endocrinology Department of Wuhan and the Chinese and Western combined hospital and the residents were randomly divided into two groups according to the conditions of inclusion, and the control group and the observation group were randomly divided into two groups. On the basis of the basic treatment of diet and exercise and the conventional blood sugar-lowering treatment of diabetes, the control group was given an Alphalan sodium tablet (Shijiazhuang Pharmaceutical Group, Oyi Pharmaceutical Co., Ltd.), one tablet daily (10 mg), and oral in the morning. On the basis of the observation group, the treatment group was treated with Tanggukang granule (Chengdu Zhonghui Pharmaceutical Co., Ltd.) three times a day and 1 bag (5 g). Both groups were supplemented with vitamins and calcium in the course of the treatment. The two groups were taken for 6 months. The clinical symptoms, fasting blood glucose (FPG), postprandial blood sugar (2h PG), glycosylated hemoglobin (Hb), bone mineral density (BMD), and the like of the two groups before and after treatment were statistically analyzed. Statistical analysis of the obtained data was carried out using the SPSS17.0 statistical software. The data between the multiple groups were compared with t-test, and the percentage of the curative effect was compared with the other two. In addition, routine indexes such as blood, urine, feces and liver and kidney function of the patient are monitored to understand the safety of the medicine. Results Compared with the two groups, the control group and the observation group had no rejection, which indicated that the sugar-pulse-kang granule is a traditional Chinese medicine concentrated granule, which is convenient to take, and the patient has good compliance. There was no significant difference in the total scores of symptoms and signs in the first two groups (P0.05), and the total score of the two groups was improved after treatment (P0.05). At the same time, the curative effect of the nimodipine on the symptoms of various Chinese medicine is found, and the patients in the observation group have a marked improvement in the symptoms of listlessness, fatigue, short-time, dry-mouth and dry-up, hand-and-foot-heart heat, spontaneous perspiration and night sweat, and tongue and tongue coating, and the total effective rate is greater than that of the control group. The difference was significant (P0.01). There was a significant difference in the soft and back pain of the waist and knees (P0.05). The values of bone mineral density in the two groups were not significant (P0.05). There was a significant difference between the two groups after the treatment (P0.05), and the control group and the observation group were significantly different (P0.05). The results showed that the two groups had no significant difference in fasting blood glucose, postprandial blood glucose and glycosylated hemoglobin (P0.05). After treatment, the blood glucose levels in the two groups were significantly improved, and the FPG, 2h PG and Hb were significantly different before the treatment (P0.05). However, there was no significant difference between the two groups (P0.05). Comparison of the monitoring of the adverse reaction of the two groups: the blood routine, the liver function and the renal function were not obvious before and after the treatment of the two groups. The abdominal discomfort in the control group was 1 case, but it was tolerated. No obvious discomfort was found in the observation group, and no serious adverse reaction occurred in the two groups. Conclusion It is found that by this study, the combined treatment of diabetes and osteoporosis with the combination of Tanggukang granule and Alphalan sodium tablets not only can obviously improve the symptoms of the traditional Chinese medicine, but also can improve the bone mineral density and control the blood sugar level. At the same time, the sugar-pulse-kang granule is a traditional Chinese medicine concentrated granule, which has the advantages of convenient administration, no obvious adverse reaction and toxic and side effects, and is worthy of popularization in the patients with diabetes and osteoporosis.
【學(xué)位授予單位】：湖北中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R587.1;R580
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