【摘要】：目的探討自擬經(jīng)驗方忍冬藤痛風顆粒聯(lián)合西藥治療濕熱蘊結(jié)型痛風性關(guān)節(jié)炎的臨床療效,為臨床診治痛風性關(guān)節(jié)炎提供有效的治療。方法選取90例濕熱蘊結(jié)型痛風性關(guān)節(jié)炎患者為研究對象,采用隨機數(shù)字表法分為對照組與治療組,對照組45例患者采用口服秋水仙堿片,發(fā)作時首次服1mg,1h后再服用0.5mg,12h后改為2次/d,共服用1周;同時服用別嘌呤醇片,0.1g/次,3次/d,療程為2周。治療組45例患者在對照組西藥治療的基礎上加用自擬經(jīng)驗方忍冬藤痛風顆粒進行治療,兩組療程均為2周。記錄中醫(yī)證候積分、VAS評分、ESR、CRP及UA 6項指標;進而比較兩組患者治療前、治療后第1周、治療后第2周與治療前及兩組間治療效果的差異。結(jié)果治療組總有效率為95.12%,而對照組總有效率為80.00%,兩組間比較差異有統(tǒng)計學意義(P0.05);兩組患者治療后中醫(yī)證候積分、VAS評分、ESR、CRP及UA6項指標較治療前有明顯改善,差異均有統(tǒng)計學意義(P0.05)。治療組治療后較對照組治療后指標改善更加顯著,差異有統(tǒng)計學意義(P0.05)。結(jié)論忍冬藤痛風顆粒聯(lián)合西藥更加有效地控制痛風性關(guān)節(jié)炎的癥狀,減輕患者的疼痛,能夠降低血沉(ESR)、C反應蛋白(CRP)、血尿酸(UA)的水平,臨床療效優(yōu)于單純西藥治療,值得臨床推廣運用。
[Abstract]:Objective to explore the clinical efficacy of the self-made prescription of honeysuckle gout granule combined with western medicine in the treatment of gouty arthritis of damp-heat accumulation type in order to provide effective treatment for clinical diagnosis and treatment of gouty arthritis. Methods 90 patients with gouty arthritis of dampness-heat accumulation type were randomly divided into two groups: control group (n = 45) and treatment group (n = 45). The control group (n = 45) took colchicine tablets orally for the first time and took them 1 mg at the time of onset, and then took 0.5 mg (n = 1) after 1 hour. After 12 hours, it was changed to 2 times per day for a total of 1 week. At the same time, allopurinol tablets, 0.1g/, 3 times a day, the course of treatment for 2 weeks. Forty-five patients in the treatment group were treated with a self-made prescription of honeysuckle gout granule on the basis of western medicine treatment in the control group. The course of treatment in both groups was 2 weeks. Six indexes of TCM syndrome score, VAS score, ESR,CRP and UA were recorded, and the difference of therapeutic effect between the two groups was compared before treatment, 1 week after treatment, 2 weeks after treatment and before treatment and between the two groups. Results the total effective rate was 95.12% in the treatment group and 80.00% in the control group. There was significant difference between the two groups (P0.05). After treatment, the TCM syndrome score, VAS score, ESR,CRP and UA6 indexes of the two groups were significantly improved compared with those before treatment, the difference was statistically significant (P0.05). After treatment, the indexes of the treatment group were improved more significantly than that of the control group, the difference was statistically significant (P0.05). Conclusion Kindongteng gout granule combined with western medicine can effectively control the symptoms of gouty arthritis and relieve the pain of the patients. It can reduce the level of serum uric acid (UA) in erythrocyte sedimentation rate (ESR), C reactive protein (CRP),) and serum uric acid. The clinical curative effect is superior to the simple western medicine treatment, it is worth clinical popularization and application.
【作者單位】： 甘肅省中醫(yī)院;甘肅中醫(yī)藥研究院;甘肅中醫(yī)藥大學;
【基金】：西北地區(qū)骨傷特色藥物療法重點研究項目 甘肅省蘭州市人才創(chuàng)新創(chuàng)業(yè)項目(2015-RC-23) 甘肅隴中骨傷學術(shù)流派傳承項目 甘肅省蘭州市科技發(fā)展計劃項目(2013-4-86)
【分類號】：R589.7

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1 丁林寶;高志欣;王s，

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