【摘要】：目的探討寧夏地區(qū)人群SLC2A9基因單核苷酸多態(tài)性rs2241480、SLC22A12基因單核苷酸多態(tài)性rs559946位點(diǎn)與高尿酸血癥患病的關(guān)聯(lián)性。方法采用1:1匹配的方法篩選體檢機(jī)構(gòu)確診的高尿酸血癥的患者和無血緣關(guān)系的健康人群各368例,收集研究對象的空腹靜脈血5ml,采用Sequenom Mass ARRAY iPLEX GOLD技術(shù)對SLC2A9基因rs2241480、SLC22A12基因rs559946位點(diǎn)進(jìn)行檢測分析。結(jié)果 SLC2A9基因rs2241480病例組和對照組在不同基因型上血尿酸水平差異有統(tǒng)計(jì)學(xué)意義(X~2=6.000,P0.050),SLC22A12基因rs559946位點(diǎn)病例組和對照組在不同基因型上血尿酸水平差異無統(tǒng)計(jì)學(xué)意義(X~2=5.700,P0.050),應(yīng)用多因子降維法(MDR),進(jìn)行基因-基因交互作用結(jié)果顯示:SLC2A9基因rs2241480位點(diǎn)與SLC22A12基因rs559946位點(diǎn)具有拮抗作用(P0.005),BMI、TG、Cr、可能為高尿酸血癥的影響因素(P0.05)。結(jié)論 SLC2A9基因rs2241480位點(diǎn)多態(tài)性與寧夏地區(qū)人群高尿酸血癥具有相關(guān)性。
[Abstract]:Objective to investigate the association of SLC2A9 gene single nucleotide polymorphism (SLC2A9) single nucleotide polymorphism (rs2241480,SLC22A12) polymorphism rs559946 locus with hyperuricemia in Ningxia population. Methods the 1:1 matching method was used to screen 368 patients with hyperuricemia diagnosed by physical examination and 368 healthy people without blood relationship. The fasting venous blood of the subjects was collected at 5ml, and the rs2241480, of SLC2A9 gene was detected by Sequenom Mass ARRAY iPLEX GOLD technique. The rs559946 locus of SLC22A12 gene was detected and analyzed. Results the levels of uric acid in patients with SLC2A9 gene rs2241480 were significantly different from those in control group (XP0.050). There was no significant difference in serum uric acid levels between patients with rs559946 locus of SLC22A12 gene and control group in different genotypes (XP0. 050). (MDR), was reduced by multivariate dimensionality reduction method. The results of gene-gene interaction showed that rs2241480 site of SLC2A9 gene and rs559946 site of SLC22A12 gene had antagonistic effect (P0.005), BMI,TG,Cr, might be the influencing factor of hyperuricemia (P0.05). Conclusion rs2241480 polymorphism of SLC2A9 gene is associated with hyperuricemia in Ningxia population.
【作者單位】： 寧夏醫(yī)科大學(xué)公共衛(wèi)生學(xué)院流行病與衛(wèi)生統(tǒng)計(jì)學(xué)系;
【基金】：寧夏高等學(xué)�？茖W(xué)技術(shù)研究項(xiàng)目(NGY2014087)
【分類號】：R589.7

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