秀麗隱桿線蟲在降脂類生物活性物質(zhì)功能評價中的應(yīng)用研究進(jìn)展
發(fā)布時間:2018-11-22 19:43
【摘要】:脂肪的過度沉積會引發(fā)高脂血癥、心腦血管疾病和糖尿病等慢性疾病。秀麗隱桿線蟲構(gòu)造簡單、身體透明、便于觀察、發(fā)育周期短、易于人工培養(yǎng)且信號通路高度保守,從而使得秀麗隱桿線蟲進(jìn)行脂肪調(diào)控的研究成為了可能。本文介紹秀麗隱桿線蟲作為研究脂肪代謝模式生物的優(yōu)勢,綜述了近些年研究驗證的具有降脂功能的生物活性物質(zhì),總結(jié)秀麗隱桿線蟲體內(nèi)的脂代謝以及在脂代謝方面的應(yīng)用研究,為研究降脂減肥藥物以及對人體肥胖等代謝障礙疾病研究提供重要依據(jù)。
[Abstract]:Excessive fat deposition can lead to hyperlipidemia, cardiovascular and cerebrovascular diseases and diabetes and other chronic diseases. Because of its simple structure, transparent body, easy observation, short developmental period, easy to be cultured artificially and highly conserved signal pathway, it is possible to study the fat regulation of C. elegans. This paper introduces the advantages of nematode elegans as a model organism for fat metabolism, and summarizes the bioactive substances with lipid-lowering function, which have been verified in recent years. This paper summarizes the lipid metabolism and its application in the body of Stereus elegans, which provides important basis for the study of lipid-lowering drugs and metabolic disorders such as obesity.
【作者單位】: 北京聯(lián)合大學(xué)應(yīng)用文理學(xué)院;
【基金】:北京市教委研究項目資助(SQKM201311417014)
【分類號】:R58;TS218
本文編號:2350347
[Abstract]:Excessive fat deposition can lead to hyperlipidemia, cardiovascular and cerebrovascular diseases and diabetes and other chronic diseases. Because of its simple structure, transparent body, easy observation, short developmental period, easy to be cultured artificially and highly conserved signal pathway, it is possible to study the fat regulation of C. elegans. This paper introduces the advantages of nematode elegans as a model organism for fat metabolism, and summarizes the bioactive substances with lipid-lowering function, which have been verified in recent years. This paper summarizes the lipid metabolism and its application in the body of Stereus elegans, which provides important basis for the study of lipid-lowering drugs and metabolic disorders such as obesity.
【作者單位】: 北京聯(lián)合大學(xué)應(yīng)用文理學(xué)院;
【基金】:北京市教委研究項目資助(SQKM201311417014)
【分類號】:R58;TS218
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