內(nèi)臟脂肪指數(shù)對成人生長激素缺乏癥患者代謝綜合征的評估作用研究
發(fā)布時間：2018-11-17 18:26
【摘要】：目的探討內(nèi)臟脂肪指數(shù)(VAI)對成人生長激素缺乏癥(AGHD)患者代謝綜合征(MS)的評估作用。方法選取2015年1月—2016年1月在重慶醫(yī)科大學附屬第一醫(yī)院確診2年及以上的AGHD患者66例為AGHD組;選取同期在本院體檢中心進行體檢的健康人群66例為對照組。并根據(jù)VAI三分位數(shù)將AGHD患者分為3組:低VAI組(n=22)、中VAI組(n=22)、高VAI組(n=22)。測量所有受試者身高、體質(zhì)量、腰圍(WC)、臀圍(HC)、血壓〔收縮壓(SBP)、舒張壓(DBP)〕等;測定空腹血糖(FPG)、空腹胰島素(FINS)、血脂〔包括總膽固醇(TC)、三酰甘油(TG)、低密度脂蛋白膽固醇(LDL-C)、高密度脂蛋白膽固醇(HDL-C)〕水平;計算BMI、腰臀比(WHR)、穩(wěn)態(tài)模型評價的胰島素抵抗指數(shù)(HOMA-IR)及VAI。通過繪制受試者工作特征(ROC)曲線,計算ROC曲線下面積(AUC),分析VAI的評估作用。結(jié)果 AGHD組中男21例,女45例;對照組中,男21例,女45例。兩組受試者年齡、身高、SBP、DBP、FPG、TC、LDL-C間差異無統(tǒng)計學意義(P0.05),而體質(zhì)量、BMI、WC、HC、WHR、FINS、TG、LDL-C、HDL-C、VAI、HOMA-IR間差異有統(tǒng)計學意義(P0.05)。不同VAI患者性別、年齡、身高、WHR、FINS、TC、LDL-C間差異無統(tǒng)計學意義(P0.05);而體質(zhì)量、BMI、WC、HC、SBP、DBP、FPG、TG、HDL-C、HOMA-IR及MS發(fā)生率間差異有統(tǒng)計學意義(P0.05)。年齡調(diào)整前后,VAI與WC、DBP、FPG、TG均呈正相關(guān)(P0.05),與HDL-C呈負相關(guān)(P0.05),與SBP無相關(guān)性(P0.05)。VAI評估AGHD患者MS的AUC為0.871〔95%CI(0.788,0.954),P0.001〕,最佳臨界值為1.9,靈敏度為0.960,特異度為0.610。結(jié)論 VAI可作為AGHD患者MS的篩查與評估手段。
[Abstract]:Objective to evaluate the effect of visceral fat index (VAI) on metabolic syndrome (MS) in adult growth hormone deficiency (AGHD) patients. Methods from January 2015 to January 2016, 66 patients with AGHD diagnosed for 2 years or more in the first affiliated Hospital of Chongqing Medical University were selected as AGHD group, and 66 healthy people who underwent physical examination in the same period were selected as control group. The patients with AGHD were divided into three groups according to the number of three digits of VAI: low VAI group (n = 22), middle VAI group (n = 22) and high VAI group (n = 22). Height, body mass, waist circumference, (WC), hip circumference, (HC), blood pressure (systolic (SBP), diastolic pressure (DBP), etc.) were measured in all subjects. Fasting blood glucose, (FPG), fasting insulin, (FINS), serum lipids (including total cholesterol, (TC), triacylglycerol, (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) were measured. Evaluation of Insulin Resistance Index (HOMA-IR) and VAI. by (WHR), Steady-state Model for calculating BMI, WHR The area (AUC), under the ROC curve was calculated by drawing the operating characteristic (ROC) curve of the subjects to evaluate the evaluation of VAI. Results there were 21 males and 45 females in AGHD group and 45 males and 45 females in control group. There was no significant difference in age, height and SBP,DBP,FPG,TC,LDL-C between the two groups (P0.05), but the body mass, BMI,WC,HC,WHR,FINS,TG,LDL-C,HDL-C,VAI, were not significantly different between the two groups (P0.05). The difference of HOMA-IR was statistically significant (P0.05). There was no significant difference in sex, age, height and WHR,FINS,TC,LDL-C among different VAI patients (P0.05). The body mass, BMI,WC,HC,SBP,DBP,FPG,TG,HDL-C,HOMA-IR and MS incidence were significantly different (P0.05). Before and after age adjustment, VAI was positively correlated with WC,DBP,FPG,TG (P0.05), and negatively correlated with HDL-C (P0.05). There was no correlation between AUC and SBP (P0.05). VAI, AUC was 0.871 (95%CI (0.7880.94), P0.001), the best critical value was 1.9, the sensitivity was 0.960and the specificity was 0.610. Conclusion VAI can be used as a screening and evaluation method for MS in AGHD patients.
【作者單位】： 重慶醫(yī)科大學附屬第一醫(yī)院內(nèi)分泌科;
【基金】：教育部基金項目(20135503120001) 國家臨床重點�？平ㄔO(shè)項目(2011) 重慶市科委自然科學基金面上項目(cstc2012jj A10035)
【分類號】：R589
[Abstract]:Objective to evaluate the effect of visceral fat index (VAI) on metabolic syndrome (MS) in adult growth hormone deficiency (AGHD) patients. Methods from January 2015 to January 2016, 66 patients with AGHD diagnosed for 2 years or more in the first affiliated Hospital of Chongqing Medical University were selected as AGHD group, and 66 healthy people who underwent physical examination in the same period were selected as control group. The patients with AGHD were divided into three groups according to the number of three digits of VAI: low VAI group (n = 22), middle VAI group (n = 22) and high VAI group (n = 22). Height, body mass, waist circumference, (WC), hip circumference, (HC), blood pressure (systolic (SBP), diastolic pressure (DBP), etc.) were measured in all subjects. Fasting blood glucose, (FPG), fasting insulin, (FINS), serum lipids (including total cholesterol, (TC), triacylglycerol, (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) were measured. Evaluation of Insulin Resistance Index (HOMA-IR) and VAI. by (WHR), Steady-state Model for calculating BMI, WHR The area (AUC), under the ROC curve was calculated by drawing the operating characteristic (ROC) curve of the subjects to evaluate the evaluation of VAI. Results there were 21 males and 45 females in AGHD group and 45 males and 45 females in control group. There was no significant difference in age, height and SBP,DBP,FPG,TC,LDL-C between the two groups (P0.05), but the body mass, BMI,WC,HC,WHR,FINS,TG,LDL-C,HDL-C,VAI, were not significantly different between the two groups (P0.05). The difference of HOMA-IR was statistically significant (P0.05). There was no significant difference in sex, age, height and WHR,FINS,TC,LDL-C among different VAI patients (P0.05). The body mass, BMI,WC,HC,SBP,DBP,FPG,TG,HDL-C,HOMA-IR and MS incidence were significantly different (P0.05). Before and after age adjustment, VAI was positively correlated with WC,DBP,FPG,TG (P0.05), and negatively correlated with HDL-C (P0.05). There was no correlation between AUC and SBP (P0.05). VAI, AUC was 0.871 (95%CI (0.7880.94), P0.001), the best critical value was 1.9, the sensitivity was 0.960and the specificity was 0.610. Conclusion VAI can be used as a screening and evaluation method for MS in AGHD patients.
【作者單位】： 重慶醫(yī)科大學附屬第一醫(yī)院內(nèi)分泌科;
【基金】：教育部基金項目(20135503120001) 國家臨床重點�？平ㄔO(shè)項目(2011) 重慶市科委自然科學基金面上項目(cstc2012jj A10035)
【分類號】：R589
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