【摘要】：目的分析糖尿病(DM)大鼠不同血糖濃度對結(jié)腸動力的影響。方法對比10只非DM大鼠與20只DM低血糖組和12只DM高血糖組大鼠的結(jié)腸推進(jìn)率及結(jié)腸縱行肌收縮活動,同時對結(jié)腸推進(jìn)率及結(jié)腸縱行肌收縮活動與血糖水平及腦利鈉肽(BNP)水平的相關(guān)性進(jìn)行分析。結(jié)果 DM高血糖組結(jié)腸推進(jìn)率低于DM低血糖組(P0.05)和非DM組(P0.05),DM低血糖組又低于非DM組(P0.05),且結(jié)腸推進(jìn)率與血糖濃度水平存在負(fù)相關(guān)(P0.05),DM高血糖組及低血糖組結(jié)腸縱行肌收縮活動振幅及頻率低于非DM組(P0.05),但與血糖濃度水平無相關(guān)性(P0.05);BNP水平及血糖濃度與結(jié)腸推進(jìn)率呈負(fù)相關(guān)性。結(jié)論隨著DM大鼠血糖濃度的升高,結(jié)腸推進(jìn)率下降。
[Abstract]:Objective to analyze the effect of different blood glucose concentration on colon motility in diabetic (DM) rats. Methods the colonic propulsive rate and the contractile activity of longitudinal colonic muscle were compared among 10 non DM rats, 20 DM hypoglycemic rats and 12 DM hyperglycemic rats. At the same time, the relationship between the colon propulsive rate, the contraction of longitudinal colon muscle and the level of blood glucose and brain natriuretic peptide (BNP) was analyzed. Results the colon propelling rate of DM hyperglycemia group was lower than that of DM hypoglycemia group (P0.05) and non-DM group (P0.05) (P0.05), and the colon propulsive rate was negatively correlated with blood glucose concentration (P0.05), while that of), DM hypoglycemia group (P0.05) was lower than that of non-DM group (P0.05). The amplitude and frequency of colon longitudinal muscle contraction in DM hyperglycemia group and hypoglycemia group were lower than those in non-DM group (P0.05), but there was no correlation with blood glucose level (P0.05). There was a negative correlation between BNP level and blood glucose concentration. Conclusion with the increase of blood glucose concentration in DM rats, the colon propulsive rate decreases.
【作者單位】： 蘭州大學(xué)第一醫(yī)院老年二科;
【基金】：甘肅省自然科學(xué)基金項(xiàng)目(No.1308RJZA219) 甘肅省胃腸病重點(diǎn)實(shí)驗(yàn)室開放課題基金(No.gswcky-2012-004)
【分類號】：R587.1;R-332

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