血漿和肽素水平對糖尿病視網(wǎng)膜病變的診斷價(jià)值
發(fā)布時(shí)間：2018-11-11 09:09
【摘要】：目的探討血漿和肽素(copeptin)水平對糖尿病視網(wǎng)膜病變(DR)的診斷價(jià)值。方法選擇2型糖尿病(T2DM)患者217例,根據(jù)DR分期標(biāo)準(zhǔn),無視網(wǎng)膜病變83例(NDR組)、非增殖性視網(wǎng)膜病變98例(NPDR組)、增殖性視網(wǎng)膜病變36例(PDR)組,另選同期體檢健康者100例(對照組)。各組均檢測血壓[收縮壓(SBP)、舒張壓(DBP)],血漿copeptin、空腹血糖(FPG)、空腹胰島素(FINS)、Hb A1C、高敏C反應(yīng)蛋白(hs-CRP)、血脂(TC、TG、HDL-C、LDL-C),計(jì)算胰島素抵抗指數(shù)(HOMA-IR)。分析血漿copeptin水平與血壓、糖尿病病程及血生化指標(biāo)的關(guān)系。采用受試者工作特征(ROC)曲線預(yù)測血漿copeptin對NPDR或PDR的診斷價(jià)值。結(jié)果 T2DM患者血漿copeptin水平明顯高于對照組(P均0.05),且隨著疾病進(jìn)展,血漿copeptin水平逐漸升高(P均0.05)。相關(guān)分析顯示,T2DM患者血漿copeptin水平與糖尿病病程、Hb A1C、HOMA-IR、Hs-CRP呈正相關(guān)(r分別為0.624、0.740、0.872、0.686,P均0.05),與血壓、血脂、FPG均無明顯相關(guān)性(P均0.05)。血漿copeptin診斷NPDR的最佳臨界值為24.6 pmol/L,敏感性為79.7%,特異性為71.6%,ROC曲線下面積(AUC)為0.871(95%CI為0.746~0.996,P0.05);血漿copeptin診斷PDR的最佳臨界值為28.3 pmol/L,敏感性為78.1%,特異性為82.1%,AUC為0.821(95%CI為0.695~0.948,P0.05)。結(jié)論血漿copeptin水平能夠?yàn)樵\斷DR提供參考。
[Abstract]:Objective to investigate the diagnostic value of plasma and peptide (copeptin) levels in diabetic retinopathy (DR). Methods 217 patients with type 2 diabetes mellitus (T2DM) were selected. According to the DR staging criteria, 83 cases of non-retinopathy (NDR group), 98 cases of non-proliferative retinopathy (NPDR group) and 36 cases of proliferative retinopathy (PDR) group) were selected. 100 healthy subjects (control group) were selected. Blood pressure [systolic pressure (SBP), diastolic blood pressure], plasma copeptin, fasting blood glucose, fasting insulin (FINS), Hb A1C, Gao Min C-reactive protein (hs-CRP), blood lipid (TC,TG,HDL-C,LDL-C) were measured in all groups. Insulin resistance index (HOMA-IR) was calculated. The relationship between plasma copeptin level and blood pressure, course of diabetes and blood biochemical index was analyzed. The diagnostic value of plasma copeptin for NPDR or PDR was predicted by using the operating characteristic (ROC) curve. Results the plasma copeptin level in T2DM patients was significantly higher than that in the control group (P 0.05), and the plasma copeptin level gradually increased with the progression of the disease (P 0.05). Correlation analysis showed that the plasma copeptin level in T2DM patients was positively correlated with the course of diabetes, Hb A1CnHOMA-IRH Hs-CRP (r = 0.624 0. 740 0. 872 鹵0. 686 鹵0. 05), and with blood pressure and blood lipid. No significant correlation was found in FPG (all P 0. 05). The best critical value for the diagnosis of NPDR by plasma copeptin was 24.6 pmol/L, the sensitivity was 79.7, the specificity was 71.6 and the area under the ROC curve was 0.871 (95%CI 0.7460.996p0.05). The best critical value of plasma copeptin for the diagnosis of PDR was 28.3 pmol/L, the sensitivity was 78.1, the specificity was 82.1 and the specificity was 0.821 (95%CI: 0.695, 0.948, P0.05). Conclusion Plasma copeptin level can provide reference for diagnosis of DR.
【作者單位】： 武漢科技大學(xué)附屬普仁醫(yī)院;臨沂市中醫(yī)醫(yī)院;
【分類號】：R587.2;R774.1
本文編號：2324392
[Abstract]:Objective to investigate the diagnostic value of plasma and peptide (copeptin) levels in diabetic retinopathy (DR). Methods 217 patients with type 2 diabetes mellitus (T2DM) were selected. According to the DR staging criteria, 83 cases of non-retinopathy (NDR group), 98 cases of non-proliferative retinopathy (NPDR group) and 36 cases of proliferative retinopathy (PDR) group) were selected. 100 healthy subjects (control group) were selected. Blood pressure [systolic pressure (SBP), diastolic blood pressure], plasma copeptin, fasting blood glucose, fasting insulin (FINS), Hb A1C, Gao Min C-reactive protein (hs-CRP), blood lipid (TC,TG,HDL-C,LDL-C) were measured in all groups. Insulin resistance index (HOMA-IR) was calculated. The relationship between plasma copeptin level and blood pressure, course of diabetes and blood biochemical index was analyzed. The diagnostic value of plasma copeptin for NPDR or PDR was predicted by using the operating characteristic (ROC) curve. Results the plasma copeptin level in T2DM patients was significantly higher than that in the control group (P 0.05), and the plasma copeptin level gradually increased with the progression of the disease (P 0.05). Correlation analysis showed that the plasma copeptin level in T2DM patients was positively correlated with the course of diabetes, Hb A1CnHOMA-IRH Hs-CRP (r = 0.624 0. 740 0. 872 鹵0. 686 鹵0. 05), and with blood pressure and blood lipid. No significant correlation was found in FPG (all P 0. 05). The best critical value for the diagnosis of NPDR by plasma copeptin was 24.6 pmol/L, the sensitivity was 79.7, the specificity was 71.6 and the area under the ROC curve was 0.871 (95%CI 0.7460.996p0.05). The best critical value of plasma copeptin for the diagnosis of PDR was 28.3 pmol/L, the sensitivity was 78.1, the specificity was 82.1 and the specificity was 0.821 (95%CI: 0.695, 0.948, P0.05). Conclusion Plasma copeptin level can provide reference for diagnosis of DR.
【作者單位】： 武漢科技大學(xué)附屬普仁醫(yī)院;臨沂市中醫(yī)醫(yī)院;
【分類號】：R587.2;R774.1
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