【摘要】：目的:觀察連續(xù)靜脈泵入碘解磷定對急性有機(jī)磷中毒的療效,氯解磷定應(yīng)用于急性有機(jī)磷中毒療效肯定,通過使用碘解磷定與使用氯解磷定作為解毒藥物對重度有機(jī)磷中毒患者進(jìn)行比較,從而評(píng)價(jià)碘解磷定臨床解毒療效,為臨床應(yīng)用此種藥物提供更多的數(shù)據(jù)參考。方法:選擇重度有機(jī)磷中毒患者52例,其中因氯解磷定藥物短缺而使用碘解磷定作為解毒藥物26例為實(shí)驗(yàn)組,使用氯解磷定作為解毒藥物26例設(shè)為對照組,分別測量兩組患者用藥前及應(yīng)用解毒藥物后第1天,用藥后第2天,用藥后第3天,用藥后第4天血漿膽堿酯酶的活性情況,并比較兩組患者的阿托品使用總量,平均住院天數(shù)、并發(fā)癥,預(yù)后以及兩種藥物副作用,從而評(píng)價(jià)碘解磷定的效果。結(jié)果:1應(yīng)用碘解磷定作為解毒藥物與應(yīng)用氯解磷定組相比血漿膽堿酯酶的復(fù)活情況無明顯差異。2應(yīng)用碘解磷定作為解毒藥物與應(yīng)用氯解磷定組相比,并沒有增加應(yīng)用阿托品的總藥量、未增加患者的住院天數(shù)。3碘解磷定組與氯解磷定組相比并沒有增加并發(fā)癥的發(fā)生率。4應(yīng)用碘解磷定與氯解磷定相比,預(yù)后情況無差異、局部反應(yīng)減少。結(jié)論:1連續(xù)靜脈泵入碘解磷定對于治療急性口服有機(jī)磷中毒療效可靠。2碘解磷定與氯解磷定相比,無論從藥物療效、阿托品用量、患者的住院天數(shù)、并發(fā)癥、預(yù)后均無明顯差異。未增加不良反應(yīng)。3碘解磷定的合理應(yīng)用可以起到氯解磷定一樣的治療效果,可以作為氯解磷定不足時(shí)的備用藥。4氯解磷定肌肉注射部位疼痛明顯,給藥方式有待進(jìn)一步探討。
[Abstract]:Objective: to observe the efficacy of continuous intravenous infusion of phosphoiodide in the treatment of acute organophosphorus poisoning. In order to evaluate the clinical detoxification efficacy of iodide and chlorophosphoridine as detoxification drugs, the clinical detoxification effect of iodide was evaluated in order to provide more data reference for clinical application of this drug in patients with severe organophosphorus poisoning. Methods: Fifty-two patients with severe organophosphorus poisoning were selected, among them, 26 cases were treated with iodide as detoxification because of shortage of chlorophosphoridine, and 26 cases as control group. The plasma cholinesterase activity before and after detoxification was measured in the two groups, and the total amount of atropine was compared between the two groups, including the first day, the second day, the third day and the fourth day after the treatment. The average length of stay, complications, prognosis, and side effects of both drugs were evaluated. Results: 1 there was no significant difference in the resurrection of plasma cholinesterase between the two groups. The total dosage of atropine was not increased, and the hospital stay was not increased. 3 the incidence of complications was not increased in the iodide group compared with the control group. 4 there was no difference in the prognosis between the two groups. The local reaction was reduced. Conclusion: 1 continuous intravenous infusion of iodide is reliable in the treatment of acute oral organophosphorus poisoning. There was no significant difference in prognosis. No increase in adverse reactions. (3) rational use of iodide can have the same therapeutic effect as chlorophosphoridine, and can be used as a backup drug in the absence of chlorophosphoridine. 4 the pain in the injection site is obvious. The method of administration needs further study.
【學(xué)位授予單位】：河北醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R595.4

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