【摘要】：目的：研究Furin基因功能多態(tài)性與維吾爾族代謝綜合征的相關(guān)性。方法：以自然人群橫斷面調(diào)查為基礎(chǔ),選取1134例維吾爾族人(包括707例代謝綜合征組和424例對(duì)照組)作為研究對(duì)象。從以往的研究中發(fā)現(xiàn)furin基因的4個(gè)代表性變異位點(diǎn)在本次研究對(duì)象中再次驗(yàn)證,并應(yīng)用TaqMan-PCR在自然人群中進(jìn)行基因型鑒定及病例對(duì)照研究。結(jié)果：Furin基因功能區(qū)的1個(gè)代表性變異位點(diǎn)rs2071410被驗(yàn)證成功,并發(fā)現(xiàn)rs2071410不同基因型在代謝綜合征組和對(duì)照組中的分布有統(tǒng)計(jì)學(xué)差異(P=0.010) 等位基因分布在代謝綜合征組與對(duì)照組中分布有統(tǒng)計(jì)學(xué)差異(P=0.546)。Logistic回歸分析,校正混雜因素,如TNF-a、BMI、血脂、血壓、血糖以及rs2071410后發(fā)現(xiàn),TT基因型仍是代謝綜合征獨(dú)立的危險(xiǎn)因素(p=0.013;OR=1.471,95% CI 1.297-1.761)。rs2071410不同基因型間TNF-a、空腹血糖、餐后2 h血糖、胰島素抵抗指數(shù)、血LDL、收縮壓等指標(biāo)的均值差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論：Furin基因變異與維吾爾族人代謝綜合征可能相關(guān),該變異可能是維吾爾族人代謝綜合征的易感基因。
[Abstract]:Objective: to study the relationship between Furin gene functional polymorphism and Uygur metabolic syndrome. Methods: based on the cross-sectional investigation of natural population, 1134 Uygur subjects (including 707 cases of metabolic syndrome and 424 cases of control group) were selected as study objects. It was found from previous studies that the four representative mutation sites of furin gene were re-verified in this study, and genotypic identification and case-control study with TaqMan-PCR were carried out in natural population. Results: rs2071410, a representative mutation site in the functional region of Furin gene, was successfully verified. It was also found that the distribution of rs2071410 genotypes in metabolic syndrome group and control group was statistically different (P0. 010) allele distribution in metabolic syndrome group was significantly different from that in control group (P0. 546). Logistic regression analysis). Adjusted for confounding factors such as TNF-a,BMI, blood pressure blood glucose and rs2071410 it was found that TT genotype was still an independent risk factor for metabolic syndrome (p0. 013). OR=1.471,95% CI 1.297-1.761). There were significant differences in fasting blood glucose, postprandial blood glucose, insulin resistance index and blood LDL, systolic blood pressure between different rs2071410 genotypes (P0.05). Conclusion: the mutation of Furin gene may be associated with metabolic syndrome in Uygur nationality, and it may be a susceptible gene of metabolic syndrome in Uygur nationality.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R589
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本文編號(hào)：2301081