2型糖尿病內(nèi)臟脂肪、脂肪因子與心臟外膜脂肪及心功能關(guān)系研究
發(fā)布時間：2018-10-21 14:18
【摘要】：目的:探討初診2型糖尿病患者內(nèi)臟脂肪、脂肪因子與心外膜脂肪及心功能的關(guān)系。方法:收集2015年08月至2016年06月20-70歲的初診2型糖尿病患者(男65例,女35例),根據(jù)我國肥胖問題工作組2003年制定的肥胖診斷標(biāo)準(zhǔn),分為OB組(肥胖體重組,31例)、OW組(超重體重組,35例)及NW組(正常體重組,34例)共100例。收集其人體測量學(xué)指標(biāo)(如年齡、性別、身高、收縮壓、舒張壓)、臨床生化學(xué)指標(biāo)(如空腹胰島素)、內(nèi)臟脂肪含量(VAT mass、VAT area)、心外膜脂肪厚度(右心室前壁脂肪、心尖部脂肪)、脂肪因子(Apelin、Omentin-1)與心功能(EF、EDV、ESV)等指標(biāo)進(jìn)行相關(guān)統(tǒng)計學(xué)處理。數(shù)據(jù)處理采用spss 17.0統(tǒng)計軟件進(jìn)行方差分析,spearman相關(guān)分析和多元線性回歸分析,P0.05表示差異有統(tǒng)計學(xué)意義。結(jié)果:1.三組在年齡、性別、身高、收縮壓、舒張壓無差異性(P0.05),OB組、OW組與NW組三組的FINS、VAT mass、VAT area、右心室前壁脂肪、心尖部脂肪、脂肪因子Apelin、Omentin-1等多項指標(biāo)方面兩兩比較差異有統(tǒng)計學(xué)意義(P0.05)。2.脂肪因子Apelin濃度與內(nèi)臟脂肪(VAT mass、VAT area)、心外膜脂肪(右心室前壁脂肪、心尖脂肪)、心功能(EDV、ESV)呈正相關(guān)(R=0.424、0.425、0.205、0.198、0.261、0.337,P0.05),與心功能(EF)呈負(fù)相關(guān)(R=-0.251,P0.05);脂肪因子Omentin-1與內(nèi)臟脂肪(VAT mass、VAT area)、心外膜脂肪(右心室前壁脂肪、心尖脂肪)、心功能(EDV、ESV)呈負(fù)相關(guān)(R=-0.539、-0.538、-0.263、-0.260、-0.338、-0.388,P0.05)。3.多元線性回歸分析提示內(nèi)臟脂肪VAT area是初診2型糖尿病心功能(EF、EDV、ESV)主要影響因素。結(jié)論:1.初診2型糖尿病內(nèi)臟脂肪與心功能相關(guān),提示減少內(nèi)臟脂肪面積對初診2型糖尿病患者心功能具有保護(hù)作用。2.脂肪因子apelin水平與內(nèi)臟脂肪、心外膜脂肪含量正相關(guān),與心功能(EF)負(fù)相關(guān),提示降低內(nèi)臟脂肪、降低apelin水平可以改善左心射血指數(shù)。3.脂肪因子omentin-1水平與內(nèi)臟脂肪、心外膜脂肪、心功能(EDV、ESV)呈負(fù)相關(guān),提示降低內(nèi)臟脂肪、提高omentin水平具有改善心功能的作用。
[Abstract]:Objective: to investigate the relationship between visceral fat, fatty factor and epicardial fat and cardiac function in newly diagnosed type 2 diabetes mellitus. Methods: type 2 diabetes patients (65 males and 35 females) aged 20-70 years from August 2015 to June 2016 were collected. The criteria for the diagnosis of obesity were established by the working Group on Obesity in China in 2003. One hundred patients were divided into OB group (obese weight group), 31), OW group (overweight weight group, 35 cases) and NW group (normal weight group, 34 cases). The anthropometric parameters (such as age, sex, height, systolic blood pressure, diastolic blood pressure), clinical biochemical indexes (such as fasting insulin), visceral fat content (VAT mass,VAT area), epicardial fat thickness (right ventricular anterior wall fat), right ventricular anterior wall fat) were collected. Apical fat), fat factor (Apelin,Omentin-1) and cardiac function (EF,EDV,ESV) were statistically correlated. Data processing using spss 17.0 statistical software for ANOVA, spearman correlation analysis and multiple linear regression analysis, P0.05 indicated the difference was statistically significant. The result is 1: 1. There was no difference in age, sex, height, systolic blood pressure and diastolic blood pressure among the three groups (P0.05 in), OB group, OW group and NW group) in FINS,VAT mass,VAT area, right ventricular anterior wall fat, apical fat, adipose factor Apelin,Omentin-1 and so on (P0.05). Fatty factor Apelin concentration and visceral fat (VAT mass,VAT area), epicardial fat) There was a positive correlation between cardiac function (EDV,ESV) and visceral fat (VAT mass,VAT area), epicardial fat, apical adipose), and a negative correlation between Omentin-1 and cardiac function (EF) (RP05), and a negative correlation between Omentin-1 and visceral fat (VAT mass,VAT area), epicardial fat, apical adipose), and heart function (EDV,ESV) (RV -0.539U -0.538U -0.263U -0.263n -0.263U -0.338- 0.388p0.05), and a negative correlation between Omentin-1 and visceral fat (VAT mass,VAT area), epicardial fat, apical fat) and cardiac function (EDV,ESV). Multiple linear regression analysis showed that visceral fat VAT area was the main factor affecting cardiac function in newly diagnosed type 2 diabetes mellitus (EF,EDV,ESV). Conclusion: 1. Visceral fat was associated with cardiac function in newly diagnosed type 2 diabetes mellitus, suggesting that reducing the area of visceral fat had protective effect on cardiac function of newly diagnosed type 2 diabetes mellitus. 2. The level of apelin was positively correlated with visceral fat and epicardial fat, and negatively correlated with cardiac function (EF), suggesting that decreasing visceral fat and decreasing apelin level could improve left ventricular ejection index. The level of omentin-1 was negatively correlated with visceral fat, epicardial fat and cardiac function (EDV,ESV), suggesting that decreasing visceral fat and increasing omentin level could improve cardiac function.
【學(xué)位授予單位】：廣西中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R587.2
本文編號：2285362
[Abstract]:Objective: to investigate the relationship between visceral fat, fatty factor and epicardial fat and cardiac function in newly diagnosed type 2 diabetes mellitus. Methods: type 2 diabetes patients (65 males and 35 females) aged 20-70 years from August 2015 to June 2016 were collected. The criteria for the diagnosis of obesity were established by the working Group on Obesity in China in 2003. One hundred patients were divided into OB group (obese weight group), 31), OW group (overweight weight group, 35 cases) and NW group (normal weight group, 34 cases). The anthropometric parameters (such as age, sex, height, systolic blood pressure, diastolic blood pressure), clinical biochemical indexes (such as fasting insulin), visceral fat content (VAT mass,VAT area), epicardial fat thickness (right ventricular anterior wall fat), right ventricular anterior wall fat) were collected. Apical fat), fat factor (Apelin,Omentin-1) and cardiac function (EF,EDV,ESV) were statistically correlated. Data processing using spss 17.0 statistical software for ANOVA, spearman correlation analysis and multiple linear regression analysis, P0.05 indicated the difference was statistically significant. The result is 1: 1. There was no difference in age, sex, height, systolic blood pressure and diastolic blood pressure among the three groups (P0.05 in), OB group, OW group and NW group) in FINS,VAT mass,VAT area, right ventricular anterior wall fat, apical fat, adipose factor Apelin,Omentin-1 and so on (P0.05). Fatty factor Apelin concentration and visceral fat (VAT mass,VAT area), epicardial fat) There was a positive correlation between cardiac function (EDV,ESV) and visceral fat (VAT mass,VAT area), epicardial fat, apical adipose), and a negative correlation between Omentin-1 and cardiac function (EF) (RP05), and a negative correlation between Omentin-1 and visceral fat (VAT mass,VAT area), epicardial fat, apical adipose), and heart function (EDV,ESV) (RV -0.539U -0.538U -0.263U -0.263n -0.263U -0.338- 0.388p0.05), and a negative correlation between Omentin-1 and visceral fat (VAT mass,VAT area), epicardial fat, apical fat) and cardiac function (EDV,ESV). Multiple linear regression analysis showed that visceral fat VAT area was the main factor affecting cardiac function in newly diagnosed type 2 diabetes mellitus (EF,EDV,ESV). Conclusion: 1. Visceral fat was associated with cardiac function in newly diagnosed type 2 diabetes mellitus, suggesting that reducing the area of visceral fat had protective effect on cardiac function of newly diagnosed type 2 diabetes mellitus. 2. The level of apelin was positively correlated with visceral fat and epicardial fat, and negatively correlated with cardiac function (EF), suggesting that decreasing visceral fat and decreasing apelin level could improve left ventricular ejection index. The level of omentin-1 was negatively correlated with visceral fat, epicardial fat and cardiac function (EDV,ESV), suggesting that decreasing visceral fat and increasing omentin level could improve cardiac function.
【學(xué)位授予單位】：廣西中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R587.2
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