肥胖對(duì)男性生殖細(xì)胞功能的影響及其機(jī)制研究進(jìn)展
發(fā)布時(shí)間:2018-10-19 19:33
【摘要】:肥胖可導(dǎo)致男性生殖功能下降,表現(xiàn)為精子數(shù)量和精液質(zhì)量下降、附睪中精子運(yùn)動(dòng)功能下降。其發(fā)生機(jī)制包括肥胖影響性激素分泌、促進(jìn)生精細(xì)胞凋亡、促進(jìn)氧化應(yīng)激和導(dǎo)致生殖細(xì)胞表觀遺傳學(xué)改變。
[Abstract]:Obesity can lead to the decrease of male reproductive function, which is manifested by the decrease of sperm quantity and semen quality, and the decrease of sperm motility in epididymis. The mechanisms include obesity affecting the secretion of sex hormones, promoting the apoptosis of spermatogenic cells, promoting oxidative stress and leading to epigenetic changes of germ cells.
【作者單位】: 延邊大學(xué)醫(yī)學(xué)院;吉林醫(yī)藥學(xué)院公共衛(wèi)生學(xué)院;
【基金】:國家自然科學(xué)基金項(xiàng)目(81472964) 吉林省自然科基金項(xiàng)目(201501012065C)
【分類號(hào)】:R589.2
本文編號(hào):2282149
[Abstract]:Obesity can lead to the decrease of male reproductive function, which is manifested by the decrease of sperm quantity and semen quality, and the decrease of sperm motility in epididymis. The mechanisms include obesity affecting the secretion of sex hormones, promoting the apoptosis of spermatogenic cells, promoting oxidative stress and leading to epigenetic changes of germ cells.
【作者單位】: 延邊大學(xué)醫(yī)學(xué)院;吉林醫(yī)藥學(xué)院公共衛(wèi)生學(xué)院;
【基金】:國家自然科學(xué)基金項(xiàng)目(81472964) 吉林省自然科基金項(xiàng)目(201501012065C)
【分類號(hào)】:R589.2
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