【摘要】：目的分析血清尿酸水平與甲狀腺功能亢進(jìn)癥患者心房顫動(dòng)的關(guān)系。方法回顧性收集2013年10月-2015年10月于該院就診的227例甲亢患者臨床資料,根據(jù)是否合并房顫,分為甲亢伴房顫組(n=49)和甲亢無(wú)房顫組(n=178),排外除甲亢以外其他疾病導(dǎo)致的房顫及其他可以引起尿酸水平變化的因素。記錄入選患者的一般資料、實(shí)驗(yàn)室檢查及心臟彩超結(jié)果,并對(duì)這些數(shù)據(jù)與房顫發(fā)生之間的關(guān)系進(jìn)行單因素和多因素Logistic回歸分析。結(jié)果甲亢伴房顫組的年齡、甲亢病程、尿素氮、肌酐、尿酸、球蛋白、左心房前后徑及左心室舒張末期內(nèi)徑均高于甲亢無(wú)房顫組(P0.05),甲亢伴房顫組的腎小球?yàn)V過率、總膽固醇、高密度脂蛋白、低密度脂蛋白、白蛋白及左室射血分?jǐn)?shù)低于甲亢無(wú)房顫組(P0.05)。通過多因素Logistic回歸分析顯示年齡(^OR:1.097,95%CI:1.036,1.160)、尿酸(^OR:1.009,95%CI:1.002,1.016)、左心房前后徑(^OR:1.294,95%CI:1.134,1.476)及左室射血分?jǐn)?shù)(^OR:0.902,95%CI:0.814,1.000)是甲亢患者房顫發(fā)生的獨(dú)立相關(guān)因素。結(jié)論尿酸水平是甲亢患者房顫發(fā)生的危險(xiǎn)因素,年齡、左心房前后徑和左室射血分?jǐn)?shù)也與甲亢患者房顫發(fā)生存在獨(dú)立相關(guān)性。
[Abstract]:Objective to analyze the relationship between serum uric acid level and atrial fibrillation in patients with hyperthyroidism. Methods the clinical data of 227 patients with hyperthyroidism from October 2013 to October 2015 were collected retrospectively. The patients were divided into hyperthyroidism with atrial fibrillation group (nnn49) and hyperthyroidism without atrial fibrillation group (nf178). Atrial fibrillation caused by diseases other than hyperthyroidism and other factors that could cause changes in uric acid level were excluded. The results of general data, laboratory examination and echocardiography were recorded, and the relationship between these data and atrial fibrillation was analyzed by univariate and multivariate Logistic regression analysis. Results the age, course of hyperthyroidism, urea nitrogen, creatinine, uric acid, globulin, left atrial anteroposterior diameter and left ventricular end-diastolic diameter in hyperthyroidism with atrial fibrillation group were higher than those in hyperthyroidism without atrial fibrillation group (P0.05). The glomerular filtration rate and total cholesterol in hyperthyroidism with atrial fibrillation group were higher than those in hyperthyroidism without atrial fibrillation group. High density lipoprotein, low density lipoprotein, albumin and left ventricular ejection fraction were lower than hyperthyroidism without atrial fibrillation group (P0.05). Multivariate Logistic regression analysis showed that age (^ OR:1.097,95%CI:1.036,1.160), uric acid (OR:1.009,95%CI:1.002,1.016), left atrial anteroposterior diameter (OR:1.294,95%CI:1.134,1.476) and left ventricular ejection fraction (OR:0.902,95%CI:0.814,1.000) were independent correlation factors of atrial fibrillation in hyperthyroidism patients. Conclusion uric acid level is a risk factor for atrial fibrillation in patients with hyperthyroidism. Age, anterior and posterior diameter of left atrium and ejection fraction of left ventricle are also associated with atrial fibrillation in patients with hyperthyroidism.
【作者單位】： 南昌大學(xué)第二附屬醫(yī)院內(nèi)分泌代謝科;
【分類號(hào)】：R541.75;R581.1

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