【摘要】：目的:探索二甲雙胍對(duì)白塞病的臨床治療價(jià)值.方法:記錄15例活動(dòng)期白塞病患者經(jīng)二甲雙胍治療入院時(shí)、出院時(shí)臨床癥狀、血常規(guī)、C-反應(yīng)蛋白、血沉、肝腎功能、血糖水平,作歷史對(duì)照;并隨訪3月,記錄疾病控制情況及副作用發(fā)生情況.結(jié)果:患者出院時(shí)臨床癥狀均得到控制,口腔潰瘍?cè)u(píng)分較入院時(shí)明顯下降(P=0.000 0),每月復(fù)發(fā)次數(shù),較入院前明顯下降(P=0.000 1).患者治療炎癥指標(biāo)包括白細(xì)胞計(jì)數(shù)、C-反應(yīng)蛋白、血沉和Ig A明顯下降(P0.05).患者出院時(shí),未發(fā)現(xiàn)二甲雙胍對(duì)紅細(xì)胞計(jì)數(shù)、血紅蛋白明顯影響,未發(fā)現(xiàn)對(duì)肝腎功能及血糖影響.同時(shí)發(fā)現(xiàn)患者谷氨酸-丙酮酸轉(zhuǎn)氨酶治療后下降,腎小球?yàn)V過(guò)率升高(P0.05).6例(40%)患者出現(xiàn)腹瀉,4例(27%)患者出現(xiàn)惡心、嘔吐、食欲下降,2例(13.3%)患者出現(xiàn)乏力,尚可耐受.結(jié)論:二甲雙胍可降低白塞病皮膚黏膜病變復(fù)發(fā)率,降低活動(dòng)期血沉、C-反應(yīng)蛋白,可能是白塞病治療可供選擇的藥物之一.
[Abstract]:Objective: To explore the clinical value of metformin in the treatment of Behcet's disease. Methods: The clinical symptoms, blood routine, C-reactive protein, erythrocyte sedimentation rate, liver and kidney function, blood glucose levels of 15 patients with active Behcet's disease were recorded at the time of admission after metformin treatment. The clinical symptoms were controlled at discharge, and the oral ulcer score was significantly lower than that at admission (P = 0.000 0). The number of recurrences per month was significantly lower than that before admission (P = 0.000 1). Inflammatory indicators included leukocyte count, C-reactive protein, erythrocyte sedimentation rate and Ig A decreased significantly (P 0.05). At the same time, 6 patients (40%) had diarrhea, 4 patients (27%) had nausea, vomiting, loss of appetite, and 2 patients (13.3%) had fatigue, which was tolerable. Guanidine can reduce the recurrence rate of skin and mucosal lesions of Behcet's disease, reduce active ESR and C-reactive protein, which may be one of the alternative drugs for the treatment of Behcet's disease.
【作者單位】： 復(fù)旦大學(xué)附屬華東醫(yī)院免疫風(fēng)濕科;
【基金】：上海衛(wèi)生系統(tǒng)第二批重要疾病聯(lián)合攻關(guān)重點(diǎn)項(xiàng)目(2014ZYJB0010)
【分類號(hào)】：R597.9

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