【摘要】：目的調(diào)查重慶地區(qū)男男性行為者(men who have sex with men,MSM)EB病毒(Epstein-Barr virus)血清流行病學(xué)現(xiàn)狀,推測(cè)MSM人群EB病毒感染和再活化情況。方法采用非概率抽樣法,對(duì)1 082例MSM(來(lái)源為2012-2015年重慶地區(qū)進(jìn)行臨床藥物試驗(yàn)預(yù)防艾滋病感染的MSM人群)和1 059名健康成人血清,采用酶聯(lián)免疫吸附測(cè)定(ELISA)方法檢測(cè)EB-VCA-IgG、EB-NA-IgG和EB-VCA-IgM,使用χ~2檢驗(yàn)對(duì)結(jié)果進(jìn)行分析,以P0.05為差異有統(tǒng)計(jì)學(xué)意義。結(jié)果1 082例MSM中HIV陽(yáng)性130例,HIV陰性952例:(1)EB病毒既往感染率在MSM、HIV陽(yáng)性、HIV陰性者中分別為1 002例(92.6%)、115例(88.5%)、887例(93.2%),其中MSM組、HIV陰性MSM組與對(duì)照組952例(89.9%)差異有統(tǒng)計(jì)學(xué)意義(P0.05)。(2)EB病毒未感染率在MSM、HIV陽(yáng)性MSM、HIV陰性MSM組分別為5例(0.5%)、1例(0.8%)、4例(0.4%),3組均顯著低于對(duì)照組53例(5.0%),差異有統(tǒng)計(jì)學(xué)意義(P0.05)。HIV陽(yáng)性與HIV陰性間差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。(3)EB病毒血清學(xué)再活化率在MSM、HIV陽(yáng)性MSM、HIV陰性MSM組中分別為52例(4.8%)、13例(10.0%)、39例(4.1%),其中HIV陽(yáng)性MSM同對(duì)照組40例(3.8%)、HIV陰性MSM組39例(4.1%)差異有統(tǒng)計(jì)學(xué)意義(P0.005)。結(jié)論(1)MSM人群EB病毒感染率高于普通人群,其發(fā)生EB病毒感染相關(guān)疾病的威脅更大。(2)非HIV感染的MSM人群EB病毒再活化率可能與正常人無(wú)差異。(3)HIV感染的MSM人群EB病毒血清學(xué)再活化率明顯增高,可能同HIV感染后機(jī)體免疫力下降有關(guān),發(fā)生EB病毒感染相關(guān)疾病的風(fēng)險(xiǎn)更大。
[Abstract]:Objective to investigate the seroepidemiological status of (men who have sex with men,MSM (EB) virus (Epstein-Barr virus) in men who have sex with men in Chongqing, and to speculate on the infection and reactivation of EB virus in MSM population. Methods using non-probabilistic sampling method, 1 082 cases of MSM (MSM population from 2012 to 2015 in Chongqing) and 1 059 healthy adults were tested. Enzyme linked immunosorbent assay (ELISA) was used to detect EB-VCA-IgG,EB-NA-IgG and EB-VCA-IgM,. 蠂 ~ 2 test was used to analyze the results. Results among 1 082 cases of MSM, there were 130 cases of HIV positive and HIV negative in 952 cases: (1) the positive rate of EB virus was 1 002 cases (92.6%), 115 cases (88. 5%) of MSM,HIV positive patients with HIV negative, 887 cases (93. 2%) of them. There was significant difference between MSM group and control group in 952 cases (89. 9%) (P0.05) EB. In the MSM,HIV positive MSM,HIV negative MSM group, 5 cases (0.5%), 1 case (0.8%) and 4 cases (0.4%) were significantly lower than the control group (53 cases, 5.0%), the difference was statistically significant (P0.05). There was no significant difference between the MSM,HIV positive group and the HIV negative group (P0.05). (3). There were 52 cases (4.8%) with MSM,HIV positive MSM,HIV negative MSM and 39 cases (4.1%) with HIV positive MSM. There was a significant difference between the HIV positive MSM group and the control group (3.8%), 39 cases (4.1%) of the HIV negative MSM group (P0.005). Conclusion (1) the infection rate of EB virus in MSM population is higher than that in general population. (2) the reactivation rate of EB virus in non-HIV infected MSM population may not be different from that in normal controls. (3) the serological reactivation rate of EB virus in MSM infected with HIV was significantly higher than that in normal controls. It may be related to the decrease of immunity after HIV infection, and the risk of EB infection related diseases is higher.
【作者單位】： 重慶醫(yī)科大學(xué)附屬第一醫(yī)院第一分院消化科;重慶醫(yī)科大學(xué)附屬第一醫(yī)院感染科 重慶市傳染病寄生蟲病學(xué)重點(diǎn)實(shí)驗(yàn)室;重慶醫(yī)科大學(xué)感染性疾病分子生物學(xué)教育部重點(diǎn)實(shí)驗(yàn)室;重慶醫(yī)科大學(xué)公共衛(wèi)生與管理學(xué)院衛(wèi)生統(tǒng)計(jì)學(xué)教研室;
【基金】：國(guó)家科技重大專項(xiàng)(2012ZX10001007)
【分類號(hào)】：R512.91;R181.3

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