【摘要】：目的探討血清補體C3(serum complement C3,sC3)降低的抗中性粒細胞胞漿抗體相關性血管炎(AAV)患者的臨床病理特征及預后。方法回顧性分析2011年1月至2016年3月我院腎內(nèi)科穿刺活檢確診的54例AAV患者的臨床及病理資料。采用免疫比濁法檢測sC3,以我院sC3測值的正常范圍下線值為截點將AAV患者分成低sC3組(sC30.9 g/L)與正常sC3組(sC3≥0.9 g/L),比較2組患者流行病學、實驗室檢查、腎臟病理、臨床癥狀、治療及預后的差異。結(jié)果低sC3組,血肌酐基線值明顯高于正常sC3組(P=0.008);C反應蛋白、eGFR值明顯低于正常sC3組(P值分別0.001、0.012);快速腎功能衰竭以及即時透析的發(fā)生率明顯高于正常sC3組(P值分別為0.035、0.014);緩解率顯著低于正常sC3組(P0.001)。Kaplan-Meier生存分析顯示低sC3組的腎臟累積生存率明顯低于正常sC3組(log-rank=10.197,P=0.001)。結(jié)論血清補體C3降低的AAV患者病情嚴重,進展較快,預后差。
[Abstract]:Objective to investigate the clinicopathological features and prognosis of patients with (AAV) with decreased serum complement C3 (serum complement C 3s C 3 (anti neutrophil cytoplasmic antibody). Methods the clinical and pathological data of 54 AAV patients diagnosed by puncture biopsy from January 2011 to March 2016 were retrospectively analyzed. The patients with AAV were divided into low sC3 group (sC30.9 g / L) and normal sC3 group (sC3 鈮，

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