【摘要】：目的探討伴隨肺纖維化的髓過氧化物酶(MPO)陽性抗中性粒細(xì)胞胞漿抗體(ANCA)相關(guān)性血管炎患者臨床特征及實驗室指標(biāo)間的相關(guān)性。方法將33例MPO陽性ANCA相關(guān)性血管炎患者分為伴肺纖維化改變的A組和不伴肺纖維化改變的B組,并以14例結(jié)締組織病相關(guān)肺間質(zhì)纖維化患者作為疾病對照組,12例健康體檢者作為健康對照組。分析上述患者的臨床資料及實驗室指標(biāo)。結(jié)果 B組患者血肌酐水平與疾病對照組及健康對照組相比均顯著升高,A組患者血肌酐水平與疾病對照組及健康對照組相比具有一定程度升高,但差異無統(tǒng)計學(xué)意義;A組、B組以及疾病對照組患者血纖維蛋白原(FIB)、D二聚體(D-D)、超敏C反應(yīng)蛋白(hsCRP)的水平均較健康對照組顯著升高(均P0.05),且在A組中,MPO的表達(dá)水平與FIB值呈正相關(guān)(r=0.64,P0.05)。結(jié)論在肺纖維化疾病中,早期監(jiān)測ANCA對于ANCA相關(guān)性血管炎的診斷具有一定臨床價值,且ANCA靶抗原MPO水平在反映血栓形成風(fēng)險中具有一定臨床意義。
[Abstract]:Objective to investigate the clinical features of myeloperoxidase (MPO) positive anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis with pulmonary fibrosis. Methods Thirty-three patients with MPO positive ANCA associated vasculitis were divided into two groups: group A with pulmonary fibrosis and group B without pulmonary fibrosis. 14 cases of connective tissue disease associated pulmonary interstitial fibrosis were used as the disease control group and 12 healthy persons as the healthy control group. The clinical data and laboratory indexes of the above mentioned patients were analyzed. Results the serum creatinine level in group B was significantly higher than that in the disease control group and the healthy control group, and the serum creatinine level in group A was significantly higher than that in the disease control group and the healthy control group. However, there was no significant difference in serum fibrinogen (FIB) D dimer (D-D) and hypersensitive C-reactive protein (hsCRP) levels in group A and control group (P 0.05), and there was a positive correlation between the expression of (FIB) and FIB in group A (r 0.64 P 0.05). Conclusion in pulmonary fibrosis disease, early monitoring of ANCA has certain clinical value in the diagnosis of ANCA associated vasculitis, and the level of ANCA target antigen MPO has a certain clinical significance in reflecting the risk of thrombosis.
【作者單位】： 華中科技大學(xué)同濟醫(yī)學(xué)院附屬同濟醫(yī)院檢驗科;武漢市第一醫(yī)院臨床免疫學(xué)實驗室;華中科技大學(xué)同濟醫(yī)學(xué)院附屬同濟醫(yī)院呼吸內(nèi)科;
【基金】：武漢市衛(wèi)生計生委科研基金資助項目(No.WX16D32)
【分類號】：R446.1;R593.2
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本文編號：2199162