【摘要】：骨髓間充質(zhì)干細(xì)胞(BMSCs)的成骨分化涉及多條信號(hào)通路,包括NF-κB受體活化因子配體(RANKL)/NF-κB受體活化因子(RANK)/骨保護(hù)素(OPG)信號(hào)通路、Wnt/β-catenin信號(hào)通路、絲裂原活化蛋白激酶(MAPK)信號(hào)通路、Smad信號(hào)通路、Notch信號(hào)通路等。這些信號(hào)通路在調(diào)控BMSCs成骨分化方面具有重要作用,其中一條或數(shù)條信號(hào)通路調(diào)節(jié)受阻,均可引起B(yǎng)MSCs成骨分化異常,進(jìn)而導(dǎo)致骨質(zhì)疏松癥等骨代謝疾病的發(fā)生。骨形態(tài)發(fā)生蛋白2(BMP-2)是骨生長(zhǎng)的啟動(dòng)因子,可誘導(dǎo)BMSCs向成骨細(xì)胞分化并促進(jìn)其發(fā)生鈣化及礦化。在BMSCs成骨分化過(guò)程中,BMP-2與Wnt/β-catenin信號(hào)通路、ERK/MAPK信號(hào)通路、Notch三條信號(hào)通路均有一定聯(lián)系。
[Abstract]:Osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) involves several signal pathways, including NF- 魏 B receptor activator ligand (RANKL) / NF- 魏 B receptor activating factor (RANK) / osteoprotegerin (OPG) signaling pathway. Mitogen-activated protein kinase (MAPK) signaling pathway, Smad signaling pathway, Notch signaling pathway and so on. These signaling pathways play an important role in regulating the osteogenic differentiation of BMSCs. One or more of these signaling pathways are blocked, which can cause abnormal osteogenic differentiation of BMSCs and lead to the occurrence of bone metabolic diseases such as osteoporosis. Bone morphogenetic protein 2 (BMP-2) is the promoter of bone growth, which can induce the differentiation of BMSCs into osteoblasts and promote its calcification and mineralization. During the osteogenic differentiation of BMSCs, BMP-2 and Wnt/ 尾 -catenin signaling pathway ERK / MAPK signaling pathway and Notch signaling pathway are all related to each other.
【作者單位】： 南京中醫(yī)藥大學(xué)醫(yī)學(xué)與生命科學(xué)學(xué)院;江蘇省中醫(yī)院;
【基金】：江蘇省自然科學(xué)基金面上項(xiàng)目(BK20131417)
【分類號(hào)】：R580

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