【摘要】：目的觀察初發(fā)糖尿病患者血清鳶尾素水平變化及其與代謝參數(shù)的關(guān)系,并探討其意義。方法初發(fā)糖尿病患者58例、糖耐量正常者64例,采用ELISA試劑測定血清鳶尾素,采用Spearman相關(guān)性分析鳶尾素水平與代謝參數(shù)(BMI、體脂肪量、體脂比、空腹血糖、餐后2 h血糖、糖化血紅蛋白、空腹胰島素、胰島素分泌指數(shù)、胰島素抵抗指數(shù)、膽固醇、甘油三酯、高密度脂蛋白膽固醇、低密度脂蛋白膽固醇、游離脂肪酸)的關(guān)系,采用Logistic回歸分析鳶尾素水平與糖尿病的關(guān)系。結(jié)果初發(fā)糖尿病、糖耐量正常者血清鳶尾素水平分別為238.03(198.97,279.43)、286.48(241.88,355.19)ng/m L,兩者相比P0.01。血清鳶尾素水平與空腹血糖(r=-0.246,P0.01)、餐后2 h血糖(r=-0.298,P0.01)、游離脂肪酸(r=-0.199,P0.05)呈負(fù)相關(guān),與高密度脂蛋白膽固醇(r=0.254,P0.01)呈正相關(guān)。血清鳶尾素水平與糖尿病發(fā)生呈負(fù)相關(guān)關(guān)系(OR=0.994,95%CI:0.990~0.998,P=0.005)。結(jié)論初發(fā)糖尿病患者血清鳶尾素水平降低。血清鳶尾素水平與糖尿病發(fā)生呈負(fù)相關(guān)。
[Abstract]:Objective to observe the changes of serum irisin level and its relationship with metabolic parameters in patients with primary diabetes mellitus and to explore its significance. Methods Serum iris was measured by ELISA reagent in 58 patients with primary diabetes mellitus and 64 patients with normal glucose tolerance. Spearman correlation analysis was used to analyze the relationship between iris level and metabolic parameters (BMI, body fat volume, body fat ratio, fasting blood glucose and 2 h postprandial blood glucose). The relationship between glycosylated hemoglobin, fasting insulin, insulin secretion index, insulin resistance index, cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol, free fatty acid, The relationship between iris level and diabetes mellitus was analyzed by Logistic regression analysis. Results the serum levels of iris in patients with primary diabetes mellitus and normal glucose tolerance were 238.03 (198.97279.43) / 286.48 (241.88355.19) ng/m / L, respectively (P < 0.01). Serum iris levels were negatively correlated with fasting blood glucose (r-0.246, P0.01), 2 h postprandial blood glucose (r-0.298, P0.01), and free fatty acids (r-0.199, P0.01), and positively correlated with high-density lipoprotein cholesterol (r-0.254, P0.01). There was a negative correlation between the serum iris level and the incidence of diabetes mellitus (OR 0.994 ~ 95CI: 0.990 ~ 0.998P0. 005). Conclusion the serum irisin level in the patients with primary diabetes decreased. Serum iris level was negatively correlated with diabetes mellitus.
【作者單位】： 上海市奉賢區(qū)中心醫(yī)院;
【基金】：上海市科學(xué)技術(shù)委員會資助項目(134119b2500)
【分類號】：R587.1

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