【摘要】：目的:本文通過檢測(cè)多囊卵巢綜合征(polycystic ovarian syndrome,PCOS)患者血清和肽素的水平,分析其與各臨床及實(shí)驗(yàn)室指標(biāo)彼此間的關(guān)系,探討和肽素與PCOS胰島素抵抗的相關(guān)性及其在協(xié)助預(yù)測(cè)PCOS代謝性疾病及心血管疾病的發(fā)生風(fēng)險(xiǎn)中的意義。方法:以鹿特丹診斷標(biāo)準(zhǔn)為診斷依據(jù),收集PCOS患者60例,同時(shí)選取60例月經(jīng)規(guī)律的育齡期婦女作為對(duì)照組�；隗w質(zhì)指數(shù)(BMI≥25kg/m 2或25kg/m 2)將PCOS組及對(duì)照組再分別分為肥胖亞組(n=30)和非肥胖亞組(n=30)。測(cè)量PCOS組及對(duì)照組所有個(gè)體的身高、體重、血壓、腰圍、臀圍,計(jì)算各受試者的體質(zhì)指數(shù)(BMI)和腰臀比(WHR)。外周靜脈血采樣檢測(cè)所有實(shí)驗(yàn)參與者血清中和肽素、空腹胰島素(FINS)、空腹血糖(FPG)、黃體生成素(LH)、睪酮(T)、卵泡刺激素(FSH)、TG、TC、LDL-C、HDL-C等生化指標(biāo),通過方程式計(jì)算胰島素抵抗指數(shù)(HOMA-IR)。對(duì)相關(guān)數(shù)據(jù)進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果:1與對(duì)照組相比,PCOS患者LH、T、收縮壓和舒張壓、TG、FPG、FTNS、HOMA-IR增高,血清和肽素水平顯著升高(P0.05),HDL-C水平降低(P0.05),而兩組年齡、BMI、WHR、TC、LDL-C、FSH無顯著性差異(P0.05)。2肥胖PCOS組BMI、WHR、TG、FPG、FINS、收縮壓和舒張壓、HOMA-IR及和肽素水平均高于非肥胖PCOS組(P0.05),HDL-C、LH顯著低于非肥胖PCOS組(P0.05);肥胖對(duì)照組BMI、WHR、TG、FPG、FINS、HOMA-IR及和肽素水平高于非肥胖對(duì)照組(P0.05),HDL-C低于非肥胖對(duì)照組(P0.05);肥胖PCOS組FPG、FINS、舒張壓、LH、T、HOMA-IR及和肽素水平均高于肥胖對(duì)照組(P0.05),HDL-C低于肥胖對(duì)照組(P0.05);非肥胖PCOS組TG、FPG、FINS、LH、T、HOMA-IR及和肽素水平均高于非肥胖對(duì)照組(P0.05);四亞組間年齡、TC、LDL、FSH無顯著差異(P0.05)。3相關(guān)性分析發(fā)現(xiàn)血清和肽素水平與BMI、WHR、TG、FPG、FINS及HOMA-IR呈正相關(guān),與HDL-C呈負(fù)相關(guān)(P0.05);與年齡、FSH、LH、T、TC、LDL-C、收縮壓和舒張壓無相關(guān)關(guān)系(P0.05)。結(jié)論:1 PCOS患者血清和肽素濃度顯著升高,且與HOMA-IR呈正相關(guān),表明和肽素可能與PCOS胰島素抵抗的發(fā)生發(fā)展有關(guān)。2和肽素與PCOS代謝參數(shù)BMI、WHR、FPG、FINS、TG呈正相關(guān),與HDL-C呈負(fù)相關(guān),表明和肽素可能在預(yù)測(cè)PCOS代謝性疾病及心血管疾病發(fā)生風(fēng)險(xiǎn)方面有重要作用。
[Abstract]:Objective: to study the relationship between serum and peptide levels in patients with polycystic ovary syndrome (polycystic ovarian) and their clinical and laboratory parameters. To investigate the relationship between PCOS insulin resistance and heopeptide and its significance in predicting the risk of PCOS metabolic disease and cardiovascular disease. Methods: 60 patients with PCOS were collected according to Rotterdam diagnostic criteria and 60 women with regular menstruation were selected as control group. On the basis of body mass index (BMI 鈮，

本文編號(hào)：2174428