【摘要】：目的:研究功能乳酸菌制劑的降血脂作用及對(duì)腸道菌的影響。方法:建立小白鼠高脂血癥動(dòng)物模型;模型小鼠30只,隨機(jī)分為:生理鹽水組、復(fù)合乳酸菌組和辛伐他汀組,每組10只。采取灌胃處理,分別灌服生理鹽水、復(fù)合乳酸菌制劑(等比例混合的植物乳桿菌、嗜酸乳桿菌和干酪乳桿菌)和降血脂藥物辛伐他汀。結(jié)果:與生理鹽水比較,乳酸菌和辛伐他汀藥物處理顯著降低了小鼠血清膽固醇(TC)、甘油三酯(TG)和低密度脂蛋白膽固醇(HDL-C)含量(P0.05);乳酸菌處理和藥物處理間TC、TG和HDL-C無顯著差異。與降血脂藥物相比,乳酸菌處理顯著增加小鼠糞便乳酸菌數(shù)量(P0.05),降低了大腸桿菌(P0.05)和腸球菌數(shù)量(P0.01)。結(jié)論:乳酸菌制劑具有降低血脂、增加腸道有益菌數(shù)量、降低腸道有害菌數(shù)量的作用。
[Abstract]:Objective: to study the effect of functional lactic acid bacteria preparation on blood lipids and intestinal bacteria. Methods: a model of hyperlipidemia in mice was established, and 30 mice were randomly divided into normal saline group, compound lactic acid bacteria group and simvastatin group with 10 rats in each group. The rats were treated by intragastric administration of normal saline, compound lactic acid bacteria (equal proportion of Lactobacillus plantarum, Lactobacillus acidophilus and Lactobacillus casei) and simvastatin, a hypolipidemic drug. Results: compared with normal saline, lactic acid bacteria and simvastatin significantly decreased the levels of serum cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (HDL-C) in mice (P0.05), but there was no significant difference between lactic acid bacteria treatment and drug treatment in TCTG and HDL-C. Compared with antilipidemic drugs, lactic acid bacteria treatment significantly increased the number of lactic acid bacteria in feces of mice (P0.05), decreased the number of Escherichia coli (P0.05) and enterococci (P0.01). Conclusion: lactic acid bacteria can reduce blood lipid, increase the number of intestinal beneficial bacteria and decrease the number of harmful bacteria.
【作者單位】： 山東臨沂羅莊中心醫(yī)院檢驗(yàn)科;山東省農(nóng)業(yè)科學(xué)院生物技術(shù)研究中心;
【基金】：國家科技支撐計(jì)劃(2012BAK17B00) 山東省科技發(fā)展計(jì)劃(2012GGC02026)
【分類號(hào)】：R589.2
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本文編號(hào)：2174009