【摘要】：目的探討單味中藥澤瀉與單味西藥格列齊特對于糖尿病的治療作用,評價(jià)中西藥物對糖尿病治療的差異。方法采用多變量重復(fù)測量設(shè)計(jì),選擇GK大鼠模型(Goto-Kakizaki wister rates,GK,原發(fā)性糖尿病大鼠模型)并將其分為澤瀉組、格列齊特組、對照組,另選wistar大鼠為正常組,給藥2周后觀察GK大鼠和wistar大鼠體重、進(jìn)食量、空腹血糖、糖耐量等指標(biāo),觀測時間及不同處理間比較采用重復(fù)測量資料的方差分析,多重比較采用LSD法,綜合評價(jià)中藥、西藥對于糖尿病治療的效果差異性。結(jié)果和給藥前相比,給藥后澤瀉組體重下降(P0.05),對照組、正常組、格列齊特組體重增加(P0.05),給藥后澤瀉組與其他三組比較體重下降(P0.05)；4組大鼠進(jìn)食量在給藥前后及組間均無統(tǒng)計(jì)學(xué)意義(P0.05)；和給藥前相比,給藥后澤瀉組和格列齊特組空腹血糖下降,給藥后澤瀉組、格列齊特組與正常組比差異均有統(tǒng)計(jì)學(xué)意義(P0.05),但格列齊特組空腹血糖下降幅度較大,可以認(rèn)為澤瀉有改善糖尿病空腹血糖的作用且作用緩慢柔和；改善空腹血糖方面,格列齊特確實(shí)較澤瀉組強(qiáng)且快(P0.05)；與給藥前相比,給藥后澤瀉組糖耐量有明顯的改善(P0.05),格列齊特組糖耐量變化無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論：1、單味中藥澤瀉、西藥格列齊特有非常好的降低空腹血糖的作用。然而西藥作為單一靶點(diǎn)研發(fā)的藥物,在降低空腹血糖作用上較中藥澤瀉強(qiáng)。2、中藥澤瀉在控制空腹血糖時,又能控制體重、改善糖耐量異常,體現(xiàn)出中藥澤瀉作為一個混合物對于一個綜合性疾病能起到多靶點(diǎn)干預(yù)的優(yōu)勢。
[Abstract]:Objective to explore the therapeutic effect of Alisma orientalis and gliclazide with single flavor and Western Medicine on diabetes, and to evaluate the difference between Chinese and Western Medicine on diabetes. Methods GK rat model (Goto-Kakizaki Wister rates, GK, primary diabetic rat model) was selected and divided into Alisma Alisma group and glitazide group. In the control group, the Wistar rats were selected as the normal group. After 2 weeks of administration, the weight, food intake, fasting blood glucose and glucose tolerance were observed in GK rats and Wistar rats. The observation time and the variance analysis of the repeated measurements were compared between the observation time and the different treatments. The multiple comparison of the LSD method was used to evaluate the difference of the effect of Western Medicine on the treatment of diabetes. The weight of Alisma orientalis group decreased (P0.05) after administration, and the weight of the control group, the normal group and the gliclazide group increased (P0.05). The weight loss of Alisma orientalis group was compared with the other three groups (P0.05). The 4 groups of rats had no statistical significance before and after the Administration (P0.05), and the Alisma orientalis group and Glee after administration. The fasting blood glucose decreased in the Zitt group, and there was a significant difference in the difference between the group of alisziziate and the normal group after administration (P0.05), but the fasting blood glucose decreased greatly in the glitazide group. It can be considered that Alisma orientalis has the effect of improving diabetic fasting blood glucose and the effect is slow and soft. Strong and fast (P0.05), compared with before administration, the sugar tolerance of Alisma orientalis group was obviously improved (P0.05), and the glucose tolerance of gliclazide group was not statistically significant (P0.05). Conclusion: 1, the single flavor Chinese Alisma orientalis, the western medicine gliclazide has a very good reduction in fasting blood glucose. However, western medicine as a single target research and development of drugs, in reducing fasting The effect of blood sugar is stronger than the Chinese medicine Alisma orientalis.2. The Chinese medicine Alisma orientalis can control the body weight and improve the abnormality of glucose tolerance when controlling the fasting blood glucose. It shows the superiority of the Chinese medicine Alisma orientalis as a mixture for a comprehensive disease.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R587.1

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