發(fā)布時間：2018-08-08 14:01

【摘要】：目的探討男性高尿酸血癥(HUA)患者中成纖維細胞因子21(FGF21)水平與血尿酸(SUA)和IR的關(guān)系。方法在體檢人群中選擇男性高尿酸血癥患者(HUA組)和健康者(NC組)各85名,HUA組以BMI水平分為HUA-高BMI亞組(n=41)及HUA-正常BMI亞組(n=44),分別檢測FGF21、Hb A_1 c、BP、血脂、HOMA-IR等參數(shù)。結(jié)果 HUA組FGF21高于NC組[(1.99±0.96)vs(1.73±0.50)ng/ml,P0.05];HUA-高BMI亞組FGF21水平高于HUA-正常BMI亞組[(2.04±3.61)vs(1.84±2.15)ng/ml,P0.05];FGF21水平與BMI、WHR、TG、ln(HOMA-IR)、FIns、SUA呈正相關(guān)(r=0.456、0.355、0.231、0.257、0.220、0.222,P0.05或P0.01);多元線性逐步回歸分析顯示,WHR、SUA、ln(HOMA-IR)、TG是血清FGF21獨立影響因素(P0.05)。結(jié)論 FGF21在男性HUA患者中升高,且與SUA、1n(HOMA-IR)、BMI、WHR及脂代謝相關(guān),其可能參與男性HUA患者的病理生理過程。
[Abstract]:Objective to investigate the relationship between the level of fibroblast factor 21 (FGF21) and serum uric acid (SUA) and IR in male patients with hyperuricemia (HUA). Methods 85 male patients with hyperuricemia (HUA group) and 85 healthy controls (NC group) were divided into two groups according to their BMI level: HUA-high BMI subgroup (nong41) and HUA-normal BMI subgroup (nb44). 緇撴灉 HUA緇凢GF21楂樹簬NC緇刐(1.99鹵0.96)vs(1.73鹵0.50)ng/ml,P0.05];HUA-楂楤MI浜氱粍FGF21姘村鉤楂樹簬HUA-姝ｅ父BMI浜氱粍[(2.04鹵3.61)vs(1.84鹵2.15)ng/ml,P0.05];FGF21姘村鉤涓嶣MI,WHR,TG,ln(HOMA-IR),FIns,SUA鍛堟鐩稿叧(r=0.456,0.355,0.231,0.257,0.220,0.222,P0.05鎴朠0.01);澶氬厓綰挎，

本文編號：2172012