異時聯(lián)體共生模型在年齡相關(guān)疾病研究中的應(yīng)用
發(fā)布時間：2018-08-08 13:29
【摘要】：組織、器官的衰老通常被認為是一個不可逆轉(zhuǎn)的過程,但近期研究發(fā)現(xiàn),通過聯(lián)體共生模型或直接將年輕個體血液靜脈注射到老年個體體內(nèi)的方法,具有一定的對抗組織或器官衰老的作用。目前,相關(guān)研究已在干細胞衰老、心腦血管疾病、老年骨折愈合、骨骼肌細胞衰老等方面取得了諸多進展。聯(lián)體共生(parabiosis)模型最初起源于19世紀,距今已有超過150年的歷史,它是通過外科手術(shù)的方式,將兩只動物連接在一起從而建立起共同的循環(huán)系統(tǒng)。作為溝通不同個體間循環(huán)系統(tǒng)的有效方式,聯(lián)體共生模型具有廣泛的應(yīng)用前景。目前,聯(lián)體共生模型所面臨的主要挑戰(zhàn)是聯(lián)體后個體出現(xiàn)的"聯(lián)體病"問題,"聯(lián)體病"也被稱為"聯(lián)體中毒",它與手術(shù)過程無關(guān),而是在聯(lián)體手術(shù)兩周后,伴隨體外循環(huán)建立和血管再通而出現(xiàn)的一種狀況,現(xiàn)有研究還不能解釋這種現(xiàn)象出現(xiàn)的原因。雖然目前聯(lián)體共生模型在世界上的應(yīng)用還并不是十分廣泛,但可以預(yù)測,聯(lián)體共生模型必將為老年病的研究做出巨大的貢獻。本文將從"聯(lián)體共生模型"的歷史、進展、挑戰(zhàn)及前景幾個方面進行綜述。
[Abstract]:The aging of tissues and organs is often considered an irreversible process, but recent studies have found that, either through conjoined symbiotic models or by injecting blood directly into older individuals, It has the function of resisting the aging of tissues or organs. At present, many advances have been made in stem cell aging, cardiovascular and cerebrovascular diseases, fracture healing in the elderly and skeletal muscle cell senescence. The conjoined symbiotic (parabiosis) model originated in the 19th century and has a history of more than 150 years. It links the two animals together through surgery to establish a common circulatory system. As an effective way to communicate the circulatory system between different individuals, the conjoined symbiosis model has a wide application prospect. At present, the main challenge for conjoined symbiotic models is the "conjoined disease" that occurs in conjoined individuals, also known as "conjoined poisoning," which has nothing to do with the surgical process, but two weeks after conjoined surgery. With the establishment of cardiopulmonary bypass and the recanalization of blood vessels, existing studies have not yet explained the causes of this phenomenon. Although the conjoined symbiosis model is not widely used in the world, it can be predicted that the conjoined symbiosis model will make a great contribution to the study of geriatric diseases. This paper reviews the history, progress, challenges and prospects of the conjoined symbiotic model.
【作者單位】： 第二軍醫(yī)大學附屬長海醫(yī)院學員管理大隊;第二軍醫(yī)大學海醫(yī)系航空醫(yī)學教研室;中韓生物醫(yī)學工程中心;第二軍醫(yī)大學附屬長海醫(yī)院創(chuàng)傷骨科;
【基金】：國家自然科學基金國際合作項目(8141101156) 上海市科委生物醫(yī)藥專項(15411950600)
【分類號】：R592
，
本文編號：2171923
[Abstract]:The aging of tissues and organs is often considered an irreversible process, but recent studies have found that, either through conjoined symbiotic models or by injecting blood directly into older individuals, It has the function of resisting the aging of tissues or organs. At present, many advances have been made in stem cell aging, cardiovascular and cerebrovascular diseases, fracture healing in the elderly and skeletal muscle cell senescence. The conjoined symbiotic (parabiosis) model originated in the 19th century and has a history of more than 150 years. It links the two animals together through surgery to establish a common circulatory system. As an effective way to communicate the circulatory system between different individuals, the conjoined symbiosis model has a wide application prospect. At present, the main challenge for conjoined symbiotic models is the "conjoined disease" that occurs in conjoined individuals, also known as "conjoined poisoning," which has nothing to do with the surgical process, but two weeks after conjoined surgery. With the establishment of cardiopulmonary bypass and the recanalization of blood vessels, existing studies have not yet explained the causes of this phenomenon. Although the conjoined symbiosis model is not widely used in the world, it can be predicted that the conjoined symbiosis model will make a great contribution to the study of geriatric diseases. This paper reviews the history, progress, challenges and prospects of the conjoined symbiotic model.
【作者單位】： 第二軍醫(yī)大學附屬長海醫(yī)院學員管理大隊;第二軍醫(yī)大學海醫(yī)系航空醫(yī)學教研室;中韓生物醫(yī)學工程中心;第二軍醫(yī)大學附屬長海醫(yī)院創(chuàng)傷骨科;
【基金】：國家自然科學基金國際合作項目(8141101156) 上海市科委生物醫(yī)藥專項(15411950600)
【分類號】：R592
，
本文編號：2171923
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