苯溴馬龍與非布司他治療老年痛風(fēng)患者的療效及安全性
發(fā)布時(shí)間：2018-08-04 18:08
【摘要】：目的探討非布司他與苯溴馬龍治療老年痛風(fēng)患者的臨床效果及安全性。方法采取前瞻性研究方法,120例老年痛風(fēng)患者采用隨機(jī)數(shù)字表法分為試驗(yàn)組和對(duì)照組各60例。試驗(yàn)組采用非布司他治療,對(duì)照組采用苯溴馬龍治療,兩組均連續(xù)用藥24 w后對(duì)比臨床效果及實(shí)驗(yàn)室指標(biāo)。結(jié)果兩組治療前、治療6 w、12 w后血尿酸(SUA)水平差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。治療第24周后,試驗(yàn)組SUA水平顯著低于對(duì)照組(P0.05);關(guān)節(jié)疼痛、關(guān)節(jié)腫脹、關(guān)節(jié)壓痛、關(guān)節(jié)活動(dòng)障礙評(píng)分、血沉(ESR)、C反應(yīng)蛋白(CRP)、血清可溶性細(xì)胞黏附因子(s ICAM)-1、血清內(nèi)皮素(ET)-1水平顯著低于對(duì)照組(P0.05);尿素氮(BUN)、肌酐(Cr)水平顯著低于對(duì)照組(P0.05)。結(jié)論非布司他治療老年痛風(fēng)患者的效果優(yōu)于苯溴馬龍,同時(shí)對(duì)患者的腎功能損害程度更小。
[Abstract]:Objective to investigate the clinical efficacy and safety of fentast and benzyl bromide Ma Long in the treatment of elderly patients with gout. Methods 120 elderly patients with gout were randomly divided into trial group (n = 60) and control group (n = 60). The experimental group was treated with non-burestar and the control group was treated with benzyl bromide Ma Long. The clinical effects and laboratory indexes were compared after 24 weeks of continuous administration of benzene bromide in both groups. Results there was no significant difference in serum uric acid (SUA) levels between the two groups before and after treatment for 6 weeks and 12 weeks (P0.05). After 24 weeks of treatment, the level of SUA in the experimental group was significantly lower than that in the control group (P0.05). The levels of serum soluble cell adhesion factor (s ICAM) -1) and endothelin (ET) 1 (ET) -1) in ESR (ESR) C reactive protein (CRP),) were significantly lower than those in control group (P0.05), and the level of (BUN), creatinine (Cr) in urea nitrogen was significantly lower than that in control group (P0.05). Conclusion the efficacy of fentinastar in the treatment of senile gout patients is better than that of phenylbromine Ma Long, and the renal function is less damaged.
【作者單位】： 綿陽(yáng)市中心醫(yī)院風(fēng)濕免疫科;
【基金】：綿陽(yáng)市痛風(fēng)及高尿酸血癥慢病管理系統(tǒng)構(gòu)建項(xiàng)目(14Q0063)
【分類號(hào)】：R589.7
本文編號(hào)：2164683
[Abstract]:Objective to investigate the clinical efficacy and safety of fentast and benzyl bromide Ma Long in the treatment of elderly patients with gout. Methods 120 elderly patients with gout were randomly divided into trial group (n = 60) and control group (n = 60). The experimental group was treated with non-burestar and the control group was treated with benzyl bromide Ma Long. The clinical effects and laboratory indexes were compared after 24 weeks of continuous administration of benzene bromide in both groups. Results there was no significant difference in serum uric acid (SUA) levels between the two groups before and after treatment for 6 weeks and 12 weeks (P0.05). After 24 weeks of treatment, the level of SUA in the experimental group was significantly lower than that in the control group (P0.05). The levels of serum soluble cell adhesion factor (s ICAM) -1) and endothelin (ET) 1 (ET) -1) in ESR (ESR) C reactive protein (CRP),) were significantly lower than those in control group (P0.05), and the level of (BUN), creatinine (Cr) in urea nitrogen was significantly lower than that in control group (P0.05). Conclusion the efficacy of fentinastar in the treatment of senile gout patients is better than that of phenylbromine Ma Long, and the renal function is less damaged.
【作者單位】： 綿陽(yáng)市中心醫(yī)院風(fēng)濕免疫科;
【基金】：綿陽(yáng)市痛風(fēng)及高尿酸血癥慢病管理系統(tǒng)構(gòu)建項(xiàng)目(14Q0063)
【分類號(hào)】：R589.7
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1 梁德榮，，徐楠，張輝明，蔡永寧，張慧琳;苯溴馬龍與磺丙舒治療痛風(fēng)的隨機(jī)對(duì)照研究[J];華西醫(yī)學(xué);1994年04期
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本文編號(hào)：2164683
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