抗酒石酸酸性磷酸酶及25-羥維生素D與老年骨質(zhì)疏松癥中腎陽虛證關(guān)系的探討
[Abstract]:Objective: to explore the relationship between tartrate-resistant acid phosphatase (TRACP-5b) 25-hydroxyvitamin D [25-(OH)-VD] and kidney yang deficiency syndrome in aged osteoporosis, and to provide a new idea for the diagnosis of kidney yang deficiency syndrome in senile osteoporosis. Method 1: 1. From March 2015 to September 2015, 30 non-senile osteoporosis patients and 30 aged osteoporosis patients diagnosed in outpatient and ward of rehabilitation department in our hospital from March 2015 to September 2015 were selected according to the criteria of inclusion of the cases, and the kidney-yang deficiency type in the TCM syndrome of senile osteoporosis was selected. The basic information of age, height and weight of each group were collected, and the serum levels of TRACP-5 and 25- (OH) -VDand serum calcium ion of (ALP), were measured. In addition, the bone mineral density of lumbar vertebrae L2-4 and femoral neck were detected by dual-energy X-ray. Finally, the data were processed by SPSS 19.0 statistical software, and the serum TRACP-5bF25- (OH) -VD and kidney yang deficiency syndrome of senile osteoporosis were analyzed. Relationship between non-Kidney Yang deficiency Syndrome and non-Osteoporosis. Results: there was no significant difference in age BMIand serum Ca ~ (2 +) levels between aged osteoporosis patients with kidney-yang deficiency, non-kidney-yang deficiency and non-osteoporosis (P0.05). There was no significant difference in BMD-ALP between non-kidney-yang deficiency group and non-kidney-yang deficiency group (P0.05). There were significant differences in serum TRACP-5b, 25- (OH) -VD levels (P0.035) .3between kidney-yang deficiency type and non-kidney-yang deficiency type in aged patients with osteoporosis (P0.035), and between kidney-yang deficiency type and non-kidney-yang deficiency type, there were significant differences in serum TRACP-5b, 25- (OH) -VD levels (P0.035). There was significant difference in serum TRACP-5bF25- (OH) -VD level in patients with osteoporosis (P0. 001), and the level of serum TRACP-5b expression in patients with deficiency of kidney yang was higher than that in patients with non-deficiency of kidney yang (P0. 001). The expression of 25-(OH)-VD in serum of kidney yang deficiency group was lower than that of non-kidney yang deficiency group. Conclusion 1. The level of serum TRACP-5bF25- (OH)-VDN ALP has a certain guiding significance in differentiating senile osteoporosis from non-osteoporosis. Serum TRACP-5bD 25-(OH)-VD can be used as an objective reference index for differentiating kidney yang deficiency type from other TCM syndromes in aged osteoporosis.
【學(xué)位授予單位】:福建中醫(yī)藥大學(xué)
【學(xué)位級別】:碩士
【學(xué)位授予年份】:2016
【分類號】:R580
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