【摘要】：目的探討類風(fēng)濕關(guān)節(jié)炎(RA)患者發(fā)生骨質(zhì)疏松性椎體壓縮性骨折的危險因素。方法以200例RA患者為研究對象,其中發(fā)生骨質(zhì)疏松性椎體壓縮性骨折34例(骨折組),未發(fā)生166例(非骨折組)。比較兩組年齡、病程、激素使用時間、激素累積使用量、血沉(ESR)、CRP、抗環(huán)瓜氨酸多肽抗體(抗CCP抗體)、28個關(guān)節(jié)疾病活動指數(shù)(DAS28),采用SPSS19.0軟件對上述資料進行單因素和多因素Logistic回歸分析。結(jié)果單因素分析結(jié)果顯示,兩組年齡、病程、激素使用時間、激素累積使用量及ESR比較P均0.05,性別、CRP、抗CCP抗體及DAS28比較P均0.05。多因素Logistic回歸分析結(jié)果顯示,年齡≥65歲、病程7 a、激素使用時間300 d、激素累積使用量2 500 mg、ESR50 mm/h為RA患者發(fā)生骨質(zhì)疏松性椎體壓縮性骨折的獨立危險因素(P均0.05)。結(jié)論高齡、病程長、激素使用時間長、激素累積使用量大、ESR升高是RA患者發(fā)生骨質(zhì)疏松性椎體壓縮性骨折的危險因素。
[Abstract]:Objective to investigate the risk factors of osteoporotic vertebral compression fracture in patients with rheumatoid arthritis (RA). Methods 200 patients with RA were studied. 34 cases of osteoporotic vertebral compression fracture (fracture group) and 166 cases of no fracture group (non-fracture group) were studied. Age, course of disease, duration of hormone use, cumulative use of hormone were compared between the two groups. Erythrocyte sedimentation rate (ESR), anti-cyclic citrulline polypeptide antibody (CCP antibody), and 28 joint disease activity index (DAS28) were analyzed by single factor and multivariate Logistic regression with SPSS19.0 software. Results the results of univariate analysis showed that the age, course of disease, time of hormone use, the amount of hormone used and the ratio of ESR were all 0.05, and the sex of CRP, anti CCP antibody and DAS28 were all 0.05. The results of multivariate Logistic regression analysis showed that age 鈮，

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