本文選題：脊柱炎 + 強直性　； 參考：《中國骨質疏松雜志》2016年01期

【摘要】：目的觀察強直性脊柱炎(AS)患者骨密度(BMD)及骨代謝標志物的變化。方法 AS組:2013年1月-2015年2月,52例,男40例、女12例,年齡(32.33±13.51)歲;健康對照組:50例,男38例、女12例,年齡(31.52±11.87)歲。檢測雙股骨頸、腰椎1-4BMD與T值;血清骨鈣素(BGP)、I型原膠原氨基端前肽(PINP)、I型膠原C-末端肽(CTX);AS組檢測C-反應蛋白(CRP)、血沉(ESR),計算病情活動指數(shù)(BASDAI)及功能指數(shù)(BASFI)。采用t檢驗與相關分析。結果 (1)AS組男、女性雙股骨頸BMD(0.943±0.163,0.940±0.148)低于對照組(1.179±0.142,1.176±0.141);腰椎1-4BMD(1.057±0.179,1.069±0.187)低于對照組(1.199±0.121,1.202±0.166);(2)AS組雙股骨頸、腰椎1-4骨質疏松及骨量減少分別是57.69%和61.53%;(3)AS組雙股骨頸、腰椎1-4BMD與BASDAI呈負相關性(r=-0.426、-0.478)(P0.05);(4)AS組男、女性BGP含量(13.47±4.36、13.85±3.75)低于對照組(21.57±3.18、20.77±4.19)(P0.05),PINP含量(24.47±3.53、23.66±4.73)低于對照組(32.25±4.33、31.17±3.20)(P0.05),CTX含量(0.80±0.13、0.74±0.17)高于對照組(0.37±0.10、0.37±0.13)(P0.05);(5)AS組BGP與雙股骨頸、腰椎1-4BMD呈正相關性(r=0.475、0.431)(P0.05),CTX呈負相關性(r=-0.516、-0.466)(P0.05)。結論 AS患者存在BMD降低,BGP、PINP含量減少,CTX增加,導致骨質疏松,應采取防治措施。
[Abstract]:Objective to observe the changes of bone mineral density (BMD) and bone metabolic markers in patients with ankylosing spondylitis (as). Methods from January 2013 to February 2015, 52 patients (male 40, female 12, age (32.33 鹵13.51) years) and healthy control group (50 cases, 38 males and 12 females, aged (31.52 鹵11.87) years) were enrolled in as group. Serum osteocalcin (BGP) type I procollagen C-terminal peptide (PINP) and type I collagen C-terminal peptide (CTX) were measured for C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), disease activity index (BASDAI) and function index (BASFI) in patients with double femoral neck and lumbar vertebrae. T test and correlation analysis were used. 緇撴灉 (1)AS緇勭敺,濂蟲，

本文編號：2105593