本文選題：邢臺市 + 2型糖尿病��； 參考：《河北醫(yī)科大學》2015年碩士論文

【摘要】：目的:通過對2011年至2014年在邢臺市醫(yī)專第二附屬醫(yī)院參加體檢的人群的2型糖尿病(Type 2 Diabetes Mellitus,T2DM)和空腹血糖受損(Impaired Fasting Glucose,IFG)的患病率描述和分析,了解不同年份邢臺市的糖尿病患病率變化趨勢,進而探討影響T2DM患病的危險因素,以便為人群的T2DM的防治工作提供科學的依據。方法:將2011~2014年在邢臺市醫(yī)專第二附屬醫(yī)院參加體檢的人群作為研究對象,從中選取體檢資料比較完整的人群納入分析對象,研究內容主要包括研究對象的人口統(tǒng)計學特征(姓名、年齡、性別)、體格測量(包括身高、體重和血壓)、血液的生化檢查(包括空腹血糖水平、血清總膽固醇、甘油三酯等)。對調查對象的T2DM和IFG患病率在2011年至2014年的變化趨勢進行描述性分析;同時對影響T2DM和IFG患病率的因素進行單因素logistic回歸分析;以是否患糖尿病作為應變量,以年齡、性別、體質指數、高血壓、血脂異常等自變量進行多因素的logistic回歸分析。結果:1研究對象人口學特征本研究中,2011年調查6541人,其中男性4519人(占69.1%),女性2022人(占30.9%);2012年調查6312人,其中男性4112人(占65.1%),女性2200人(占34.9%);2013年調查8107人,其中男性5535人(占68.3%),女性2572人(占31.7%);2014年調查6394人,其中男性4267人(占66.7%),女性2127人(占33.3%)。2從2011年至2014年,T2DM的標化患病率呈增長趨勢(6.09%,6.51%,7.94%,7.72%),差異有統(tǒng)計學意義(χ2=102.39,P0.05)。從2011年至2012年、2013年至2014年T2DM標準化后的患病率變化不大,而2013年T2DM標準化后的患病率與2012年相比,患病率上升了21.97%,提示在2011年至2012年與2013年至2014年2型糖尿病的發(fā)病基本沒變化,而2012年至2013年2型糖尿病的發(fā)病明顯增高。3從2011年至2014年,IFG標化患病率隨年份增長也呈現整體上升趨勢(8.51%,8.55%,10.85%,10.45%),而且差異均有統(tǒng)計學意義(χ2=143.82,P0.05)。IFG標化后患病率與T2DM變化趨勢相似,只有在2012年至2013年變化明顯,患病率上升了26.90%。4 2011年至2014年不同性別T2DM的患病率及變化趨勢。2011年至2014年男性T2DM標化患病率有逐漸增高的趨勢(6.62%,7.34%,9.21%,9.56%);而女性T2DM標化患病率隨著年份的增長變化不大(4.86%,4.13%,5.85%,4.97%),但呈現上下波動狀態(tài)。5 2011年至2014年不同性別IFG的患病率及變化趨勢。2011年至2014年,男性IFG標化患病率呈增長趨勢(9.62%,10.56%,9.58%,12.97%),女性IFG標化患病率隨著年份的增長變化的規(guī)律性不強(5.88%,4.58%,6.97%,5.58%),呈現波動狀態(tài)。6在2011年至2014年,每個年份男性T2DM的標化患病率均明顯高于女性(6.62%4.86%、7.34%4.13%、9.21%5.85%、9.56%4.97%),而且差異均具有統(tǒng)計學意義(χ2=18.68,59.79,66.01,99.65,P0.05)。2011年,男性的T2DM患病率在51~歲年齡段達到最高值,而女性的T2DM患病率在61~歲年齡段達到高峰,在41~50歲年齡段,男性與女性差異最大,且差異有統(tǒng)計學意義(χ2=24.45,P0.05);在2012、2013和2014年,男性和女性的T2DM患病率均在61~歲年齡段達到最高值,在各個年齡段,男性的T2DM患病率均高于女性,而且在41~50歲年齡段差異最大,差異均有有統(tǒng)計學意義(χ2=15.07,28.63,24.20,P0.05)。7年齡對T2DM患病率的影響:在2011年-2014年,在41~50歲、51~60歲、61~歲年齡段T2DM的患病率均與18~30歲年齡段有差異,差異有統(tǒng)計學意義,而且隨年齡組的遞增,患T2DM的風險性增大。8超重/肥胖對T2DM的患病率的影響:超重組(24~28)和肥胖組(≥28)相對于正常組,T2DM患病率差異明顯,而且有統(tǒng)計學意義;超重和肥胖是T2DM患病的危險因素,肥胖組相對正常組T2DM患病的風險性比超重組相對正常組T2DM患病的風險性要大,而且隨著年份的增長,風險性均增大。9高血壓、高TC癥、高TG癥對T2DM患病率的影響:在2011-2014年,高血壓者、高TC癥者和高TG癥者T2DM的患病率與血壓正常者、TC正常者和TG正常者的患病率均有差異,差異均有統(tǒng)計學意義,而且高血壓、高TC癥和高TG癥均是T2DM患病的危險因素。10多因素非條件Logistic回歸分析的結果表明,2011、2012、2013和2014年,在排除了其他混雜因素后,年齡、超重/肥胖、高血壓、高TG癥均是T2DM發(fā)生的危險因素(OR值1),說明年齡較高者比年齡低者患T2DM的機率大,超重或肥胖者比BMI正常者患T2DM的風險高,血壓越高、TG值越高,TC值越高,T2DM患病的危險性就越大。結論:1在2011年至2014年,邢臺市成年居民T2DM以及IFG患病率迅速增長。2男性T2DM以及IFG的患病率明顯高于女性,而且在近四年間,在不同的年齡段差異明顯。3年齡越大、高血壓患者、超重和肥胖者、血脂異常者患糖尿病的風險升高。
[Abstract]:Objective: to describe and analyze the prevalence of type 2 diabetes (Type 2 Diabetes Mellitus, T2DM) and impaired fasting blood glucose (Impaired Fasting Glucose, IFG) in the Second Affiliated Hospital of Xingtai medical secondary hospital from 2011 to 2014, to understand the trend of diabetes prevalence in different years in Xingtai and to explore the influence of T2DM. The risk factors of the disease are provided in order to provide scientific basis for the prevention and control of T2DM in the population. Methods: the population of the Second Affiliated Hospital of Xingtai Medical College, 2011~2014, was taken as the research object. Characteristics (name, age, sex), physical measurement (including height, weight and blood pressure), biochemical examination of blood (including fasting blood glucose level, serum total cholesterol, triglyceride, etc.). Descriptive analysis of the prevalence rates of T2DM and IFG in the subjects from 2011 to 2014; and factors affecting the prevalence of T2DM and IFG Single factor Logistic regression analysis, logistic regression analysis was performed on the independent variables of age, sex, body mass index, hypertension, and dyslipidemia. Results: in 1 subjects, 6541 people were investigated in this study in 2011, including 4519 men (69.1%), 2022 women (30.9%); 2012 The annual survey of 6312 people, of which 4112 were male (65.1%) and 2200 women (34.9%), 8107 were investigated in 2013, including 5535 men (68.3%) and 2572 women (31.7%). In 2014, there were 6394 people, among them male 4267 (66.7%) and.2 from 2011 to 2014. The standardized prevalence rate of T2DM was increasing. 7.72%) the difference was statistically significant (x 2=102.39, P0.05). From 2011 to 2012, the prevalence rate of T2DM after the standardization of 2013 to 2014 was not significant, but the prevalence rate of T2DM after 2013 T2DM was higher than that in 2012. From 2 to 2013, the incidence of type 2 diabetes was significantly higher in.3 from 2011 to 2014. The IFG standardized prevalence rate also increased with annual growth (8.51%, 8.55%, 10.85%, 10.45%), and the difference was statistically significant (x 2=143.82, P0.05).IFG standardized prevalence rate was similar to that of T2DM, only from 2012 to 2013. The prevalence rate of 26.90%.4 was increased from 2011 to 2014. The prevalence and changes of T2DM in different sexes were increased from.2011 to 2014 (6.62%, 7.34%, 9.21%, 9.56%), while the prevalence rate of T2DM in women changed little with year's increase (4.86%, 4.13%, 5.85%, 4.97%), but the incidence of T2DM was.5 20. The prevalence and change trend of different sex IFG from 11 to 2014 from.2011 to 2014, the male IFG standardized prevalence rate was increasing (9.62%, 10.56%, 9.58%, 12.97%). The prevalence rate of female IFG standardization was not strong (5.88%, 4.58%, 6.97%, 5.58%) with the year's increase, which showed a fluctuating state.6 from 2011 to 2014, each year male T2 The standardized prevalence rate of DM was significantly higher than that of women (6.62%4.86%, 7.34%4.13%, 9.21%5.85%, 9.56%4.97%), and the difference was statistically significant (x 2=18.68,59.79,66.01,99.65, P0.05).2011 years, and the prevalence rate of male T2DM reached the highest in 51~ age, while the T2DM prevalence rate of women reached the peak in the age segment of the 61~ year. The difference between male and female is the greatest, and the difference is statistically significant (x 2=24.45, P0.05). In 20122013 and 2014, the prevalence rate of T2DM in men and women reached the highest in the age of 61~. In all age groups, the prevalence rate of T2DM in male was higher than that in women, and the difference was the largest in 41~50 age group (x 2=15.). The effect of 07,28.63,24.20, P0.05).7 age on the prevalence of T2DM: in -2014 year 2011, at 41~50 years, 51~60 years, and 61~ years old, the prevalence of T2DM is different from that of 18~30 years old, and the difference is statistically significant, and the risk of T2DM is increased with the increase of age group. The prevalence of T2DM was significantly different in the obese group (> 28) compared with the normal group, and there was a statistically significant difference. Overweight and obesity were risk factors for T2DM disease. The risk of T2DM prevalence in the obese group was higher than that in the normal group compared with the normal group T2DM, and with the growth of the year, the risk increased.9 hypertension and high TC The effect of high TG's disease on the prevalence of T2DM: in 2011-2014 years, the prevalence of T2DM in high blood pressure, high TC and high TG patients is different from those of normal people with normal blood pressure, normal TC and normal TG, and the difference is statistically significant, and hypertension, high TC and high TG are all.10 multifactor non conditional Logisti. The results of C regression analysis showed that age, overweight / obesity, hypertension, and high TG were all risk factors for T2DM (OR value 1) after excluding other confounding factors in 201120122013 and 2014, indicating that older people were more likely to suffer from T2DM than those with older age, and those who were overweight or fat were at higher risk for T2DM than those with normal BMI, the higher the blood pressure, the greater the TG value, the higher the TG value. Higher, the higher the TC value, the greater the risk of T2DM disease. Conclusion: 1 from 2011 to 2014, the prevalence rate of T2DM and IFG in adult residents in Xingtai was rapidly increased, and the prevalence rate of.2 male T2DM and IFG was significantly higher than that of women. And in the last four years, the greater the.3 age in different age groups, the hypertension, overweight and obese, blood lipid difference. The risk of diabetes is higher.
【學位授予單位】：河北醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：R587.1

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