發(fā)布時間：2018-06-22 01:02

  本文選題：下丘腦 + 胰島素��； 參考：《東北師范大學(xué)》2015年碩士論文

【摘要】：隨著人們生活水平的不斷提高,糖尿病患者也越來越多,初期無明顯癥狀,很容易被人們忽視。一旦出現(xiàn)糖尿病癥狀,以現(xiàn)有醫(yī)學(xué)手段仍無法治愈,只能通過控制飲食、服藥,甚至注射胰島素來治療。嚴(yán)重時,糖尿病可引發(fā)全身的并發(fā)癥,甚至有生命危險。要了解糖尿病就要了解血糖控制過程,因此研究血糖調(diào)節(jié)過程對糖尿病的治療有重要作用。生理系統(tǒng)是一個極其復(fù)雜的系統(tǒng),所以不能用簡單的方法模擬和解釋。近年來用非線性模型來模擬生理過程成為熱點研究之一,為臨床治療和了解發(fā)病機制提供了一種理論預(yù)測。已經(jīng)在心臟病的治療、心電信號模擬、神經(jīng)網(wǎng)絡(luò)混沌研究、細(xì)胞節(jié)律現(xiàn)象、腦電分析等方面得到應(yīng)用,在內(nèi)分泌系統(tǒng)中,腎上腺軸的非線性系統(tǒng)研究比較成熟,而鮮見對胰島軸展開的研究。本文依據(jù)生理學(xué)理論,分析了血糖-胰島素在體內(nèi)的調(diào)節(jié)過程,以及下丘腦-胰島軸的血糖反饋調(diào)節(jié)過程,依據(jù)酶促反應(yīng)動力學(xué)原理和非線性動力學(xué)理論,建立了新的下丘腦-胰島軸血糖控制過程的非線性動力學(xué)方程,并利用matlab軟件求出方程的周期振蕩解、倍周期解以及混沌解,從而在理論上呈現(xiàn)出胰島素是以脈沖方式分泌的,并可能是混沌行為的結(jié)論。
[Abstract]:With the improvement of people's living standard, there are more and more patients with diabetes mellitus. Once diabetes symptoms are present, there is no cure by existing medical means, which can only be treated by diet control, medication, and even insulin injection. In severe cases, diabetes can lead to systemic complications and even life-threatening. To understand diabetes, we need to understand the process of blood glucose control, so the study of blood glucose regulation plays an important role in the treatment of diabetes. Physiological system is an extremely complex system, so it can not be easily simulated and explained. In recent years, the use of nonlinear models to simulate physiological processes has become one of the hot topics, which provides a theoretical prediction for clinical treatment and understanding of pathogenesis. Has been used in the treatment of heart disease, ECG simulation, neural network chaos research, cell rhythm phenomenon, EEG analysis, etc. In the endocrine system, the nonlinear system of adrenal axis is relatively mature. But few studies have been carried out on islet axis. Based on physiological theory, the regulation process of blood glucose and insulin in vivo and the feedback regulation of blood glucose in hypothalamus-islet axis were analyzed in this paper. According to the kinetic principle of enzymatic reaction and nonlinear kinetic theory, A new nonlinear dynamic equation of hypothalamus-islet axis blood glucose control process is established. The periodic oscillatory solution, double periodic solution and chaotic solution of the equation are obtained by using matlab software. Thus, it is theoretically shown that insulin is secreted in a pulsed manner. And may be the conclusion of chaotic behavior.
【學(xué)位授予單位】：東北師范大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R587.1

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本文編號：2050833