本文選題：血鉛值 + 鋅原卟啉�。� 參考：《環(huán)境與職業(yè)醫(yī)學(xué)》2017年04期

【摘要】：[目的]探討影響職業(yè)性鉛作業(yè)工人血鉛水平的因素,并分析其與血鋅原卟啉(ZPP)的相關(guān)性。[方法]以江蘇省某蓄電池廠所有454名員工(男性300名,女性154名)作為研究對(duì)象,對(duì)其工作崗位空氣中鉛濃度進(jìn)行現(xiàn)場(chǎng)檢測(cè)。采用問(wèn)卷調(diào)查的形式記錄工人吸煙、飲酒等行為習(xí)慣,測(cè)定其血鉛及ZPP,將血鉛質(zhì)量濃度大于400μg/L作為高血鉛組,100μg/L作為低血鉛組,100~400μg/L之間的人群作為中血鉛組,進(jìn)行統(tǒng)計(jì)分析。以血鉛作為接觸標(biāo)志,ZPP作為效應(yīng)標(biāo)志,采用基準(zhǔn)劑量計(jì)算軟件(BMDS 2.6.1)計(jì)算血鉛基準(zhǔn)劑量和基準(zhǔn)劑量的95%可信區(qū)間下限(BMDL)。[結(jié)果]三組研究對(duì)象的單因素分析中,血鉛值、年齡、受教育程度、工種、工齡、接鉛工齡、吸煙和飲酒分布差異有統(tǒng)計(jì)學(xué)意義;logistic回歸分析發(fā)現(xiàn)受教育程度低、工種為操作工、飲酒、接鉛工齡短是血鉛水平增高的危險(xiǎn)因素;線性相關(guān)分析顯示血鉛在100~400μg/L范圍內(nèi)和ZPP具有正相關(guān)性(P0.001)。以血鉛作為接觸標(biāo)志,ZPP作為效應(yīng)標(biāo)志,血鉛基準(zhǔn)劑量和BMDL分別為562.23μg/L和441.13μg/L(P=0.78)。[結(jié)論]在血鉛水平較高時(shí),血鉛與ZPP具有較好的正相關(guān)性,ZPP是鉛接觸的敏感效應(yīng)生物標(biāo)志。在實(shí)際工作中應(yīng)用ZPP作為低血鉛水平(100μg/L)的篩查指標(biāo)時(shí),應(yīng)注意和其他指標(biāo)聯(lián)合應(yīng)用。
[Abstract]:[objective] to investigate the factors influencing blood lead level in workers exposed to occupational lead, and to analyze its correlation with ZPPs in blood zinc protoporphyrin. [methods] A total of 454 employees (300 males and 154 females) from a battery factory in Jiangsu Province were studied. The smoking and drinking behaviors of workers were recorded by questionnaire, and their blood lead and ZPPs were measured. The blood lead concentration was more than 400 渭 g / L in the high blood lead group and 100 渭 g / L in the low blood lead group as the middle blood lead group, and the blood lead concentration was 100 渭 g / L in the low blood lead group and 400 渭 g / L in the low blood lead group. Blood lead was used as the contact marker and ZPP was used as the effect marker. The reference dose calculation software (BMDS 2.6.1) was used to calculate the blood lead baseline dose and the lower limit of 95% confidence interval of the reference dose. [results] in univariate analysis of the three groups, there were significant differences in the distribution of blood lead, age, education, type of work, length of service, exposure to lead, smoking and alcohol consumption. Logistic regression analysis showed that the educational level was low. The risk factors for the increase of blood lead level were drinking alcohol and short lead exposure, and the linear correlation analysis showed that there was a positive correlation between blood lead and ZPP in the range of 100 渭 g / L and ZPP (P 0.001 / L). Using blood lead as the contact marker, the baseline dose of blood lead and BMDL were 562.23 渭 g / L and 441.13 渭 g / L respectively. [conclusion] when the level of blood lead is high, blood lead and ZPP have a good positive correlation. ZPP is a sensitive biomarker of lead exposure. When using ZPP as a screening index of 100 渭 g / L low blood lead level in practical work, we should pay attention to the application of ZPP in combination with other indexes.
【作者單位】： 東南大學(xué)公共衛(wèi)生學(xué)院;江蘇省疾病預(yù)防控制中心職業(yè)病防治所;
【基金】：江蘇省臨床醫(yī)學(xué)科技專項(xiàng)(編號(hào):BL2014082)
【分類號(hào)】：R135.11

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