本文選題：維吾爾族 + 漢族��； 參考：《新疆醫(yī)科大學(xué)》2015年碩士論文

【摘要】：目的本研究主要探討維生素D缺乏和自身免疫性甲狀腺疾病在維漢兩民族之間的關(guān)系及差異研究。方法本研究一共納入1655名于2013年5月在烏魯木齊某社區(qū)行流行病學(xué)調(diào)查的本地居民,通過(guò)檢測(cè)其血清25(OH)D、甲狀腺相關(guān)抗體水平、尿碘等生化指標(biāo),統(tǒng)計(jì)分析維漢兩民族間血清維生素D水平與自身免疫性甲狀腺疾病之間的關(guān)系及差異,并用統(tǒng)計(jì)學(xué)中的相關(guān)與回歸分析血清25(OH)D水平對(duì)甲狀腺自身抗體的影響。結(jié)果①總?cè)巳鹤陨砻庖咝约谞钕偌膊∠嚓P(guān)抗體陽(yáng)性率(TPOAb和TGAb)為32.63%(單純TGAb抗體陽(yáng)性率為6.4%),男性人群為21%、女性人群為37.5%。女性甲狀腺相關(guān)抗體陽(yáng)性率顯著高于男性(χ2=43.81,P0.001),漢族人群抗體陽(yáng)性率為29.8%、維吾爾族人群抗體陽(yáng)性率為36.3%,維吾爾族抗體陽(yáng)性率高于漢族(χ2=7.691,P=0.006)；②維生素D缺乏的患病率分別為男性63.29%、女性77.03%、維吾爾族76.5%、漢族54.6%,女性顯著高于男性、維族顯著高于漢族(P均0.001)；維生素D不足的患病率男性為30.95%、女性為15.37%、維族為9.27%、漢族為28.32%、無(wú)論民族差異男性均顯著高于女性,無(wú)論性別差異漢族均顯著高于維族(P均0.001)；維生素D充足率在男女之間無(wú)統(tǒng)計(jì)學(xué)差異,無(wú)論男女性別差異、漢族人群維生素D充足率均顯著高于維族(P均0.001)；③無(wú)論民族差異,維生素D缺乏組與比維生素D不足組相比,自身免疫性甲狀腺疾病患病率有降低的趨勢(shì),但差異無(wú)統(tǒng)計(jì)學(xué)意義；兩組中漢族人群AITDs患病率分別為30.3%、27.5% (χ2=0.717,P=0.397),維族人群AITDs患病率分別為36.1%、34.8%(χ2=0.047,P=0.829)；無(wú)論民族差異,碘過(guò)量組與碘缺乏組相比,自身免疫性甲狀腺疾病患病率有增高的趨勢(shì),但差異無(wú)統(tǒng)計(jì)學(xué)意義,碘缺乏組和碘過(guò)量組中,漢族人群AITDs患病率分別為33.9%、34.7% (χ2=0.023,P=0.497),維族人群AITDs患病率分別為35.6%、40.2% (χ2=0.607,P=0.436)；④Logistic回歸模型分析中,調(diào)整了年齡,吸煙狀態(tài)、BMI、腹圍、甲狀腺減退病程,是否合并甲狀腺結(jié)節(jié)及尿碘水平等指標(biāo)后,40-60歲的漢族女性血清維生素D水平與自身免疫性甲狀腺疾病呈負(fù)相關(guān)(B=-0.052、P=0.009)。結(jié)論維生素D缺乏在烏魯木齊地區(qū)普通成人中很常見(jiàn),對(duì)于40-60歲的烏魯木齊社區(qū)漢族女性,維生素D可以作為評(píng)價(jià)自身免疫性甲狀腺病的一個(gè)風(fēng)險(xiǎn)指標(biāo),可能參與自身免疫性甲狀腺疾病的發(fā)生發(fā)展。
[Abstract]:Objective to investigate the relationship and difference between vitamin D deficiency and autoimmune thyroid disease in the Uygur two ethnic groups. Methods a total of 1655 local residents who were investigated in a community of Urumqi in May 2013 were included in this study, and the serum level of serum 25 (OH) D, the level of thyroid related antibody, and urine iodine were detected. The relationship and difference between vitamin D level and autoimmune thyroid disease among the two nationalities of the Han Dynasty were statistically analyzed, and the effects of serum 25 (OH) D level on the thyroid autoantibodies were analyzed by statistical correlation and regression. Results (1) the positive rate of autoimmune thyroid disease related antibodies (TPOAb and TPOAb) TGAb) 32.63% (the positive rate of TGAb antibody was 6.4%), the male population was 21%, the positive rate of thyroid related antibody in female population was significantly higher than that of male (x 2=43.81, P0.001), the positive rate of antibody in the Han population was 29.8%, the positive rate of Uygur population was 36.3%, and the positive rate of Uygur antibody was higher than that of the Han nationality (x 2=7.691, P=0.006). (2) the prevalence of vitamin D deficiency was 63.29% for men, 77.03% in women, 76.5% in Uygur, 54.6% in Han, and significantly higher in women than in men. The prevalence of vitamin D was significantly higher than that of Han (P 0.001); the prevalence rate of vitamin D deficiency was 30.95%, women were 15.37%, Uygur was 9.27% and Han was 28.32%, no matter the ethnic differences were significantly higher than those of women. No matter the sex difference, the Han nationality was significantly higher than the Uygur (P 0.001), and the vitamin D adequacy ratio was not statistically significant between men and women. The vitamin D adequacy ratio of the Han population was significantly higher than that of the Uygur (all P 0.001). The prevalence of adenosine was reduced, but the difference was not statistically significant; the prevalence rate of AITDs in the two groups of Han population was 30.3%, 27.5% (x 2=0.717, P=0.397), and the prevalence rate of AITDs in the Uygur population was 36.1%, 34.8% (2=0.047, P=0.829), respectively. No matter the ethnic difference, the iodine excess group was compared with the iodine deficiency group and the autoimmune thyroid disease patients were compared. The incidence of disease was higher, but the difference was not statistically significant. The prevalence rate of AITDs in the iodine deficiency group and the iodine excess group was 33.9%, 34.7% (x 2=0.023, P=0.497), and the prevalence rate of AITDs in the Uygur population was 35.6%, 40.2% (2=0.607, P=0.436), respectively. (4) the Logistic regression model was used to adjust the age, smoking, BMI, abdominal circumference, and nail shape. The level of vitamin D in serum of 40-60 year old Han women was negatively correlated with autoimmune thyroid disease (B=-0.052, P=0.009). Conclusion vitamin D deficiency is common among ordinary adults in Urumqi area, and vitamin D deficiency is very common for Han women of 40-60 years old in the community of Han nationality. D can be used as a risk indicator for autoimmune thyroid disease and may be involved in the development of autoimmune thyroid diseases.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R581.9
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本文編號(hào)：2032863