本文選題：英夫利昔 + 藥物性狼瘡��； 參考：《中國藥房》2017年14期

【摘要】：目的:分析英夫利昔致藥物性狼瘡(DIL)的發(fā)生規(guī)律及特點,為安全用藥提供參考。方法:以"英夫利昔""狼瘡"等為檢索詞,檢索2002年1月-2016年6月中國學(xué)術(shù)期刊全文數(shù)據(jù)庫(CJFD)、維普中文科技期刊數(shù)據(jù)庫(VIP)及Pub Med等數(shù)據(jù)庫,對英夫利昔致DIL的相關(guān)文獻(xiàn)進(jìn)行分析。結(jié)果:共檢索得到有效文獻(xiàn)30篇,共計31例DIL患者。其中,男性8例(25.81%),女性23例(74.19%),年齡50歲的中老年患者17例(54.84%);發(fā)生在5~24周有20例(64.51%);單獨使用英夫利昔方案者16例(51.61%);主要臨床表現(xiàn)為皮疹或光敏性腸炎(15例)、關(guān)節(jié)痛(16例,多發(fā)性關(guān)節(jié)炎及滑膜炎)和發(fā)熱(12例),有5例患者同時出現(xiàn)上述3種癥狀;實驗室檢查主要表現(xiàn)為抗核抗體、雙鏈DNA抗體及抗組蛋白抗體陽性;除1例患者繼續(xù)用藥外,其余30例DIL患者給予停藥或甾體激素治療,其中26例患者于停藥或治療后6個月之內(nèi)癥狀消失,1例患者病情惡化。結(jié)論:英夫利昔致DIL的發(fā)生涉及患者年齡、性別、疾病種類、家庭史等多種因素,臨床應(yīng)加強(qiáng)用藥監(jiān)測,減少不良反應(yīng)的發(fā)生。
[Abstract]:Objective: to analyze the occurrence and characteristics of infliximab-induced drug-induced lupus erythematosus (Dil) in order to provide reference for safe drug use. Methods: using "inflixion" and "lupus" as the key words, we searched the full text database of Chinese academic journals from January 2002 to June 2016, including CJFDG, VIPs, Pub Med and so on. To analyze the related literature of inflexion induced DIL. Results: a total of 30 effective literatures were retrieved, including 31 patients with DIL. Among them, 8 males (25. 81%), 23 females (74. 19%), 17 middle-aged and aged 50 years old patients (54.84); 20 cases (64.51m) who occurred in 524 weeks; 16 cases (51.61) were treated with infliximab alone; the main clinical manifestations were rash or Guang Min enteritis (15 cases) and arthralgia (16 cases). There were 12 cases of polyarthritis and synovitis, and 5 cases of fever had the above three symptoms simultaneously. Laboratory examination mainly showed that the antinuclear antibody, double strand DNA antibody and anti histone antibody were positive. The other 30 patients with DIL were given withdrawal or steroid therapy, of which 26 patients had their symptoms disappeared within 6 months after withdrawal or treatment. Conclusion: the incidence of DIL caused by infliximab is related to age, sex, disease type, family history and so on. The clinical monitoring of DIL should be strengthened to reduce the incidence of adverse reactions.
【作者單位】： 蚌埠市第三人民醫(yī)院藥學(xué)部;
【分類號】：R593.24

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