發(fā)布時(shí)間：2018-06-12 12:30

  本文選題：2型糖尿病 + 肥胖　； 參考：《吉林大學(xué)》2017年碩士論文

【摘要】：目的:了解T2DM患者中的OP分布狀態(tài),并對(duì)其影響因素進(jìn)行分析,為早期診斷、早期防治DM并發(fā)OP提供臨床線索。方法:收集2014年9月~2015年12月于吉林大學(xué)第二醫(yī)院內(nèi)分泌科住院T2DM患者891例,包含男性479例,女性412例�；仡櫥颊咦≡浩陂gBMD水平、Hb A1c水平、血脂、血壓、空腹血糖、甲狀腺功能等指標(biāo),根據(jù)患者的BMD水平分為骨量正常組(335例)、骨量減少組(399例)以及OP組(157例),對(duì)比分析三組T2DM患者的性別、年齡、體重指數(shù)、腰圍、病程、煙齡、高血壓病史、FPG、FCP、2小時(shí)C肽、BMD值、Hb A1c、TG、TC、LDL和甲狀腺功能的差異,并進(jìn)行相關(guān)性分析。結(jié)果:1)在性別方面,T2DM患者中OP組女性比例明顯高于男性,P0.0001。2)在BMI水平方面,BMI≥28(kg/m2)的T2DM患者中,OP的比率顯著降低,P0.0001。3)在腰圍水平方面,男性≥90cm以及女性≥85cm的T2DM患者中,OP的比例降低,P=0.0002。4)在高齡、低腰圍水平、低BMD水平、低TG水平的T2DM患者中,其OP的比例均顯著增高,均為P0.0001;患有高血壓、高LDL水平的T2DM患者中,其OP所占比重較高,分別為P=0.0121,P=0.0465;OP組中,Hb A1c值較高,然而差別不具有統(tǒng)計(jì)學(xué)的意義P=0.7237;而煙齡、病程、甲功、血清C肽水平在三種骨量分組中的差別均無統(tǒng)計(jì)學(xué)的意義。5)通過研究潛在危險(xiǎn)因素和不同骨量分組的相關(guān)性得出,在T2DM中,年齡、LDL水平和OP呈正相關(guān)性;腰圍、空腹血糖、TG值以及股骨頸、腰椎1-4、髖部的BMD值與OP呈負(fù)相關(guān)性。結(jié)論:1)2型糖尿病者中年齡、性別、腰圍、血壓、血糖、血脂、BMI水平、BMD水平和骨質(zhì)疏松發(fā)生密切相關(guān)。2)腹型肥胖和高BMI水平為OP的保護(hù)因子。3)2型糖尿病人群中,女性、高齡、低體質(zhì)量病人中骨質(zhì)疏松的發(fā)生風(fēng)險(xiǎn)增加,這些患者應(yīng)注意定期篩查骨密度水平,同時(shí)針對(duì)骨質(zhì)疏松做出早期預(yù)防。4)T2DM病人中,高血壓、血脂代謝紊亂、血糖控制不佳均會(huì)引起OP的產(chǎn)生風(fēng)險(xiǎn)增高,所以控制血糖穩(wěn)定的同時(shí)也要保持血壓、血脂水平的正常。
[Abstract]:Objective: to investigate the distribution of op in patients with T2DM and analyze its influencing factors so as to provide clinical clues for early diagnosis and early prevention and treatment of DM complicated with op. Methods: from September 2014 to December 2015, 891 T2DM patients, including 479 males and 412 females, were enrolled in the Department of Endocrinology, second Hospital of Jilin University. The levels of BMD and HbA1c, blood lipids, blood pressure, fasting blood glucose, thyroid function and so on were reviewed. According to the BMD level of the patients, they were divided into normal bone mass group (335 cases) and bone mass reduction group (399 cases) and op group (157 cases). Sex, age, body mass index, waist circumference, course of disease, smoking age of three groups of T2DM patients were compared and analyzed. The BMD value of 2-hour C peptide in FPGG / FCPT was compared with the difference between HbA1cTGN TCU LDL and thyroid function, and the correlation analysis was carried out. Results the proportion of females in op group was significantly higher than that in males (P0.0001.2). The ratio of op in T2DM patients with BMI 鈮，

本文編號(hào)：2009677