本文選題：胰島功能 + 體脂分布��； 參考：《新疆醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:探討維吾爾族男性人群中胰島功能與體脂分布及其他影響因素的相關(guān)性。方法:使用隨機(jī)整群抽樣的方法在新疆維吾爾自治區(qū)烏魯木齊市二道橋片區(qū)納入597名男性,采集人體學(xué)參數(shù),予以問(wèn)卷調(diào)查、口服葡萄糖耐量試驗(yàn)并行實(shí)驗(yàn)室檢查,采用生物電阻抗法測(cè)量體脂分布。結(jié)果:受試者中糖代謝異常與正常組的體質(zhì)指數(shù)(BMI)、腰臀比(WHR)、內(nèi)臟脂肪面積均有統(tǒng)計(jì)學(xué)差異(P0.05)。按體脂分布各組分分別進(jìn)行分組,各組間胰島素抵抗指數(shù)均有統(tǒng)計(jì)學(xué)差異(P0.05)。線性相關(guān)顯示,內(nèi)臟脂肪面積、體脂百分比、BMI、WHR、甘油三酯(TG)、血糖、血壓與HOMA-IR呈正相關(guān)(P0.05),低密度脂蛋白、睪酮、性激素結(jié)合球蛋白、25羥維生素D與HOMA-IR呈負(fù)相關(guān)(P0.05),血糖、甘油三酯與HOMA-?呈負(fù)相關(guān)(P0.05)。逐步回歸分析顯示,空腹血糖(FPG)、內(nèi)臟脂肪面積、糖代謝分類(lèi)為lnHOMA-?的主要影響因素,FPG、內(nèi)臟脂肪面積、腰臀比、腰圍、性激素結(jié)合球蛋白、BMI、睪酮為lnHOMA-IR的主要影響因素。結(jié)論:不論全身性還是中心性肥胖均有胰島素抵抗的風(fēng)險(xiǎn),血糖、內(nèi)臟脂肪面積為胰島素抵抗、胰島β細(xì)胞功能的主要影響因素,性激素結(jié)合球蛋白及睪酮在男性中或許可作為胰島素抵抗的預(yù)測(cè)因子。
[Abstract]:Objective: to investigate the relationship between islet function, body fat distribution and other influencing factors in Uygur male population. Methods: 597 men were enrolled in Erdaoqiao district of Urumqi, Xinjiang Uygur Autonomous region by random cluster sampling method. Anthropometric parameters were collected, questionnaire was conducted and oral glucose tolerance test was performed in laboratory. The distribution of body fat was measured by biological impedance method. Results: body mass index (BMI), waist to hip ratio (WHR) and visceral fat area of the subjects with abnormal glucose metabolism were significantly different from those of the normal group (P 0.05). The insulin resistance index of each group was significantly different according to body fat distribution (P 0.05). Linear correlation showed that the area of visceral fat, percentage of body fat, triglyceride TGG, blood sugar, blood pressure and HOMA-IR were positively correlated with HOMA-IR, low density lipoprotein, testosterone, androgen binding globulin 25 hydroxyvitamin D were negatively correlated with HOMA-IR, blood glucose, triglyceride and HOMA-IR were negatively correlated. There was a negative correlation (P0.05). Stepwise regression analysis showed that fasting blood glucose FPGN, visceral fat area, glucose metabolism classified as lnHOMA-? The main influencing factors were FPG, visceral fat area, waist-to-hip ratio, waist circumference, sex hormone binding globulin BMIand testosterone as the main influencing factors of lnHOMA-IR. Conclusion: both systemic and central obesity have the risk of insulin resistance, blood glucose and visceral fat area are the main factors influencing the function of islet 尾 cells. Sex hormone binding globulin and testosterone may be used as predictors of insulin resistance in men.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R587.1

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