本文選題：痛風(fēng) + 高尿酸血癥��； 參考：《衛(wèi)生研究》2017年02期

【摘要】：目的分析男性血清鐵蛋白水平和超敏C反應(yīng)蛋白與痛風(fēng)的關(guān)系及痛風(fēng)患病風(fēng)險(xiǎn)。方法選擇確診為痛風(fēng)病的男性患者600例作為痛風(fēng)組,高尿酸血癥者600例作為高尿酸血癥組,隨機(jī)抽取同期男性健康體檢者600例為對(duì)照組。收集三組人群體檢及相關(guān)指標(biāo)的檢測(cè)信息,如身高、體重、血清鐵蛋白(SF)、超敏C反應(yīng)蛋白(hs-CRP)、尿酸(UA)、空腹血糖(FPG)、甘油三酯(TG)、總膽固醇(TC)等。結(jié)果血清鐵蛋白(SF)分析結(jié)果顯示:痛風(fēng)患者SF平均水平為135.27μg/L,明顯高于高尿酸血癥組114.45μg/L(P0.05)和對(duì)照組76.02μg/L(P0.05);而hs-CRP水平在痛風(fēng)患者高達(dá)0.3 mg/dL,明顯高于高尿酸血癥組和對(duì)照組的0.13和0.09mg/d L(P均0.05)。在校正BMI、TG、TC、FPG和UA五項(xiàng)混雜因素后,高尿酸血癥組和痛風(fēng)組SF與hs-CRP水平呈正相關(guān);而對(duì)照組SF與hs-CRP水平無關(guān)聯(lián)。多因素Logistic回歸分析,SF(≥69.01μg/L)是高尿酸血癥發(fā)生的危險(xiǎn)因素;在校正了BMI、TG、TC、FPG和UA五項(xiàng)混雜因素后,高水平的SF(≥155.78μg/L)是痛風(fēng)發(fā)生的危險(xiǎn)因素,OR為2.678(95%CI 1.484~4.833);且較高水平的hs-CRP(0.9 mg/dL)也是痛風(fēng)發(fā)生的危險(xiǎn)因素,OR為3.104(95%CI 1.727~5.580);而SF和hs-CRP并不是高尿酸血癥發(fā)生的危險(xiǎn)因素。結(jié)論痛風(fēng)患者SF和hs-CRP明顯升高,揭示SF、hs-CRP可能參與了痛風(fēng)患者的發(fā)病過程。
[Abstract]:Objective to analyze the relationship between serum ferritin level, hypersensitive C reactive protein and gout and the risk of gout. Methods 600 male patients with gout were selected as gout group, 600 hyperuricemia patients as hyperuricemia group and 600 male healthy persons as control group. To collect the information of physical examination and related indexes of three groups, such as height, weight, serum ferritin, hypersensitive C-reactive protein hs-CRP, UAA, FBG, TGN, TCc, etc. Results the average level of SF in gout patients was 135.27 渭 g / L, which was significantly higher than that in hyperuricemia group (114.45 渭 g / L P 0.05) and control group (76.02 渭 g / L P 0.05), while the level of hs-CRP in gout patients was as high as 0.3 mg / dL, which was significantly higher than that in hyperuricemia group and control group (0.13 渭 g / L, P 0.05). After adjusting for the five confounding factors, the levels of SF and hs-CRP in hyperuricemia group and gout group were positively correlated, but there was no correlation between SF and hs-CRP level in control group. Multivariate logistic regression analysis showed that SF (鈮，

本文編號(hào)：2000940