本文選題：燃煤型氟中毒 + 成人　； 參考：《環(huán)境與健康雜志》2017年07期

【摘要】：目的探討燃煤型氟暴露對(duì)成人血清骨形態(tài)發(fā)生蛋白-2(BMP-2)和BMP-3表達(dá)的影響。方法于2013年9月,對(duì)貴州省六盤水市水城縣陡箐鄉(xiāng)(氟病區(qū))和花嘎鄉(xiāng)(對(duì)照區(qū))成人進(jìn)行氟斑牙診斷和尿氟檢測(cè),使用酶聯(lián)免疫吸附法檢測(cè)血清BMP-2、BMP-3濃度。結(jié)果燃煤型氟中毒病區(qū)成人氟斑牙檢出率為72.58%(90/124),高于對(duì)照區(qū)[8.96%(6/67)],且病區(qū)成人尿氟濃度高于對(duì)照區(qū),差異均有統(tǒng)計(jì)學(xué)意義(P0.01);病區(qū)成人血清BMP-2、BMP-3濃度與對(duì)照區(qū)比較,差異均無統(tǒng)計(jì)學(xué)意義(P0.05);氟病區(qū)及對(duì)照區(qū)成人血清BMP-2、BMP-3濃度在不同性別間比較差異無統(tǒng)計(jì)學(xué)意義(P0.05);氟病區(qū)18~39歲組成人血清BMP-2濃度較對(duì)照區(qū)高,差異有統(tǒng)計(jì)學(xué)意義(Z=-2.186,P0.05);而其余各年齡段成人血清BMP-2、BMP-3濃度均無明顯變化。氟病區(qū)成人血清BMP-2、BMP-3濃度在不同氟斑牙分度及尿氟濃度間比較差異均無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論過量的氟可能導(dǎo)致成人血清BMP-2濃度升高,氟可能是影響血清BMP-2表達(dá)的因素之一。
[Abstract]:Objective to investigate the effect of fluorine exposure on the expression of bone morphogenetic protein -2 (BMP-2) and BMP-3 in adult serum. Methods in September 2013, the dental fluorosis and Urine Fluorine detection were carried out in the adults of Dou Qing township (fluorosis area) and Hua GA township (control area) in Liupanshui, Guizhou Province. The serum BMP-2 and BMP-3 concentrations were detected by enzyme linked immunosorbent assay. The detection rate of dental fluorosis in adults with coal burning fluorosis was 72.58% (90/124), higher than that of control area [8.96% (6/67)], and the concentration of Urine Fluorine in adult was higher than that in the control area, the difference was statistically significant (P0.01). There was no significant difference in the concentration of BMP-2 and BMP-3 in the adult serum from the control area (P0.05), and the serum B in the fluorosis area and the control area. There was no significant difference in the concentration of MP-2 and BMP-3 between the same sex differences (P0.05). The serum BMP-2 concentration of 18~39 years old in the fluorosis area was higher than that of the control area, and the difference was statistically significant (Z=-2.186, P0.05), but there was no significant change in the serum BMP-2 and BMP-3 concentration in the rest of the age groups. The serum BMP-2, BMP-3 concentration of the adult in the fluorosis area was in different dental fluorosis. There was no significant difference between the fraction and the concentration of urine fluorine (P0.05). Conclusion excessive fluoride may lead to the increase of serum BMP-2 concentration in adults, and fluorine may be one of the factors that affect the expression of serum BMP-2.
【作者單位】： 貴州醫(yī)科大學(xué)公共衛(wèi)生學(xué)院環(huán)境衛(wèi)生學(xué)教研室;環(huán)境污染與疾病監(jiān)控省部共建教育部重點(diǎn)實(shí)驗(yàn)室;貴州省疾病預(yù)防控制中心慢性病防治研究所;
【基金】：國家自然科學(xué)基金(81560515) 科技部國家科技支撐計(jì)劃課題(2013BAI05B03)
【分類號(hào)】：R599.1

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