雙能X線吸收法在分析髖部骨折患者股骨頸結(jié)構(gòu)強(qiáng)度中的應(yīng)用
本文選題:雙能X線吸收法 + 骨強(qiáng)度; 參考:《廣東醫(yī)學(xué)》2017年15期
【摘要】:目的利用雙能X線吸收法(DXA)研究骨質(zhì)疏松性股骨頸骨折患者和健康受試者髖關(guān)節(jié)的幾何結(jié)構(gòu)強(qiáng)度,探討各強(qiáng)度參數(shù)與骨折發(fā)生危險(xiǎn)性的關(guān)系。方法在進(jìn)行了100例健康者DXA雙側(cè)股骨頸骨密度(FN BMD)、骨結(jié)構(gòu)參數(shù)[截面轉(zhuǎn)動(dòng)慣量(CSMI)、截面面積(CSA)、截面模量(SM)、皮質(zhì)骨內(nèi)徑(ED)、皮質(zhì)骨外徑(OD)、皮質(zhì)骨厚度(CT)、髖軸長(zhǎng)度(HAL)、股骨頸干角(NSA)、髖關(guān)節(jié)強(qiáng)度指數(shù)(SI)]配對(duì)t檢驗(yàn)比較的基礎(chǔ)上,對(duì)59例股骨頸骨折患者與年齡匹配的健康組DXA髖部幾何結(jié)構(gòu)強(qiáng)度參數(shù)進(jìn)行比較,并作為骨折危險(xiǎn)因素變量帶入條件logistic回歸方程分析,計(jì)算各參數(shù)與骨折發(fā)生的相對(duì)危險(xiǎn)性。結(jié)果雙側(cè)髖部的DXA參數(shù)均呈高度正相關(guān)(r=0.847~0.998,P0.05),部分參數(shù)存在較小但有統(tǒng)計(jì)學(xué)意義的差異。骨折組女性的FN BMD、CSMI、CSA、SM、CT和SI顯著低于對(duì)照組女性。骨折組男性的FN BMD、CSMI、CSA、SM和SI顯著低于對(duì)照組男性。經(jīng)身高、體重和FN BMD校正后,骨折組女性的CSMI、SM仍然顯著低于對(duì)照組女性,骨折組男性的SM顯著低于對(duì)照組男性。HAL為男、女性組入選股骨頸骨折模型的唯一因素,其OR值分別為1.385和1.269。結(jié)論髖部幾何結(jié)構(gòu)參數(shù)差異可以解釋骨折患者股骨近端骨強(qiáng)度的降低,DXA測(cè)量的HAL參數(shù)對(duì)于男、女性髖部骨折風(fēng)險(xiǎn)預(yù)測(cè)具有重要的臨床意義。
[Abstract]:Objective to study the geometrical structural strength of hip joint in patients with osteoporotic femoral neck fracture and healthy subjects by dual energy X-ray absorptiometry (DXA), and to explore the relationship between the strength parameters and the risk of fracture. Methods the bone structure parameters of DXA bilateral femoral neck bone density (BMD) were studied in 100 healthy subjects. The parameters of bone structure [cross section rotational inertia (CRI), cross section area (CSAA), cross section modulus (SMN), cortical bone internal diameter (EDN), cortical bone diameter (ODN), cortical bone thickness (CTT), hip axis length (HALM)], and femoral axis length (HALM), were studied in 100 healthy subjects. On the basis of paired t test, NSAA, hip strength index (SI) were compared. The geometric structural strength parameters of hip in 59 patients with femoral neck fracture were compared with those in age-matched healthy group, and the relative risk of fracture was calculated by using the conditional logistic regression equation as a variable of fracture risk factors. Results the DXA parameters of bilateral hips were positively correlated with each other (P 0.05). The CT and SI of FN BMDS CSMIA SMCT and SI in fracture group were significantly lower than those in control group. The FN BMD CSMIA SM and SI in fracture group were significantly lower than those in control group. After height, weight and FN BMD were adjusted, CSMI-SM in fracture group was still significantly lower than that in control group, and SM in fracture group was significantly lower than that in control group. Their OR values were 1.385 and 1.269, respectively. Conclusion the difference of hip geometry parameters can explain the decrease of bone strength in proximal femur and the HAL parameters measured by DXA have important clinical significance for predicting the risk of hip fracture in male and female.
【作者單位】: 暨南大學(xué)附屬第一醫(yī)院核醫(yī)學(xué)科;
【基金】:廣東省醫(yī)學(xué)科研基金立項(xiàng)項(xiàng)目(編號(hào):A2015129)
【分類號(hào)】:R580;R683;R816.8
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