本文選題：山東地區(qū) + 漢族人��； 參考：《山東大學(xué)》2017年碩士論文

【摘要】：目的維生素D是一種具有多種重要生理功能的類固醇類激素,長期不足或缺乏維生素D則可能會導(dǎo)致骨量減少甚至骨質(zhì)疏松癥以及引發(fā)心血管系統(tǒng)疾病、自身免疫性疾病以及神經(jīng)、精神類疾病等。本研究通過調(diào)查居住在山東地區(qū)漢族成年人血清25(OH)D的水平,獲取本地區(qū)的成年人維生素D水平現(xiàn)狀,并初步分析其影響因素。方法回顧性分析經(jīng)山東大學(xué)齊魯醫(yī)院及山東省醫(yī)學(xué)會骨質(zhì)疏松學(xué)組血清維生素D水平網(wǎng)絡(luò)調(diào)研平臺收集的2015年4月-2016年8月的行血清25(OH)D檢測的研究對象檢測數(shù)據(jù)共849例,所有研究對象血清樣本均為早晨抽取,排除患有糖尿病、甲狀腺疾病者(74例),患有腎臟疾病者(41例),患有消化系統(tǒng)疾病者(31例),服用過維生素D和(或)鈣補(bǔ)充劑者(42例),患有嚴(yán)重高脂血癥及其他可能嚴(yán)重影響血清維生素D水平的疾病者(44例),非山東省居民(76例),非漢族居民(33例),年齡小于18歲樣本(52例),最終共計456例納入本項研究。將研究對象分別按照性別、年齡段、職業(yè)、居住地區(qū)(沿海地區(qū)與內(nèi)陸地區(qū)、城鎮(zhèn)與鄉(xiāng)村)、采血時間(季節(jié))進(jìn)行細(xì)化分組研究,使用Stata 14.0對不同分組數(shù)據(jù)進(jìn)行比較分析。所有研究對象對本研究均知情同意,所有樣本均采用化學(xué)發(fā)光免疫法,所用檢測盒均為Elecsys(?)Vitamin D total assay。結(jié)果1.456名研究對象血清25(OH)D平均值為14.25±8.23ng/m1,維生素D不足率為94.1%,維生素D缺乏率為78.5%;2.按研究對象年齡分組,不同年齡段研究對象的血清25(OH)D水平有明顯差異,但其維生素D不足率與缺乏率無明顯差異;3.按研究對象性別分組,不同性別研究對象的血清25(OH)D水平無明顯差異,維生素D的不足率與缺乏率亦無明顯差異;4.按研究對象職業(yè)分組,不同職業(yè)研究對象的血清25(OH)D水平有明顯異,其中職業(yè)為農(nóng)民的研究對象血清25(OH)D水平明顯高于其他職業(yè)研究對象水平,但是不同職業(yè)研究對象的維生素D不足率與缺乏率無明顯差異;5.按研究對象居住地區(qū)分組,居住在內(nèi)陸地區(qū)和沿海地區(qū)研究對象的血清25(OH)D水平、維生素D不足率與缺乏率均無明顯差異;居住在城鎮(zhèn)和鄉(xiāng)村的不同研究對象的血清25(OH)D水平、維生素D不足率與缺乏率均有明顯差異,居住在鄉(xiāng)村的研究對象的血清25(OH)D水平明顯高于居住在城鎮(zhèn)的研究對象,而其維生素D不足率與缺乏率均明顯低于居住在城鎮(zhèn)的研究對象;6.按研究對象采血時間分組,不同采血月份樣本的血清25(OH)D水平、維生素D不足率與缺乏率之間有明顯差異,采血時間在第三季度(7月、8月、9月)的樣本血清25(OH)D水平明顯高于其他季度的采血樣本的水平,而其維生素D不足率與缺乏率明顯低于其他季度采血樣本的水平;7.多元線性回歸與Logistic回歸分析結(jié)果提示研究對象的性別、是否居住在沿海地區(qū)與血清25(OH)D水平無明顯相關(guān)性,研究對象的年齡、職業(yè)、是否居住在城鎮(zhèn)、樣本的采血時間與血清25(OH)D水平有相關(guān)性,年齡、職業(yè)、是否居住在城鎮(zhèn)、樣本的采血時間是人群維生素D不足與缺乏的主要影響因素。結(jié)論1.山東省漢族成年人血清25(OH)D平均水平普遍較低,平均水平為14.25±8.23,人群中94.1%的個體維生素D處于不足狀態(tài),78.5%的個體維生素D處于缺乏狀態(tài);2.山東省漢族成年人維生素D營養(yǎng)狀態(tài)與研究對象年齡、職業(yè)、是否居住在鄉(xiāng)村、樣本的采血時間有明顯相關(guān)性;與研究對象的性別、是否居住在沿海地區(qū)無明顯相關(guān)性。3.維生素D缺乏的危險因素為:①30歲及以下女性和70歲以上老年人②公務(wù)員、干部、學(xué)生和教師等職業(yè)③長期居住于城鎮(zhèn)地區(qū)者④冬季
[Abstract]:Objective vitamin D is a steroid hormone with a variety of important physiological functions. Long term deficiency or lack of vitamin D may lead to osteopenia, osteoporosis, and cardiovascular diseases, autoimmune diseases, and neurologic, mental diseases, etc. This study was conducted to investigate the Han nationality inhabited in Shandong. The level of serum level of 25 (OH) D of the year was obtained, and the status of vitamin D in adults was obtained and its influencing factors were preliminarily analyzed. Methods the serum level of vitamin D in the osteoporosis group of Qilu Hospital of Shandong University and the network of serum vitamin D level in the osteoporosis group of the Shandong Medical Association were collected in April 2015 and August of -2016 year in April 2015. The subjects were tested for 849 cases. All the subjects were sampled in the morning, excluding diabetes, thyroid disease (74), patients with kidney disease (41 cases), patients with digestive system diseases (31 cases), vitamin D and (or) calcium supplements (42 cases), severe hyperlipidemia, and other serious influence on blood. Patients with vitamin D level (44 cases), non Shandong residents (76 cases), non Han residents (33 cases), age less than 18 years old (52 cases), and the final total of 456 cases were included in this study. The subjects were refined according to sex, age, occupation, residential area (along the sea area and inland area, town and country), blood collecting time (season). Group study, Stata 14 was used to compare the data of different groups. All the subjects were informed of the study. All the samples were treated with chemiluminescence immunoassay, and the detection boxes were Elecsys (?) Vitamin D total assay. results. The average value of serum 25 (OH) D was 14.25 + 8.23ng/m1, and vitamin D deficiency rate was 14.25. 94.1%, the vitamin D deficiency was 78.5%; 2. according to the age group, the level of serum 25 (OH) D of the subjects of different age groups had obvious difference, but there was no significant difference between the deficiency rate and the deficiency rate of vitamin D; 3. the level of serum 25 (OH) D of the subjects of different sex was no significant difference, and the deficiency rate of vitamin D The level of serum 25 (OH) D of the subjects of different occupations was significantly different, and the level of serum 25 (OH) D of the occupational group was significantly higher than that of other occupational research subjects, but there was no significant difference in the rate of vitamin D deficiency between the subjects of different career research subjects and the deficiency rate; 5 The levels of serum 25 (OH) D, vitamin D deficiency and deficiency rate of subjects living in inland and coastal areas were not significantly different from those in inland areas and coastal areas. The levels of serum 25 (OH) D and vitamin D infeet and deficiency rates of different research subjects living in towns and villages were significantly different, and the study of living in rural areas The level of serum 25 (OH) D of the subjects was significantly higher than that of the research subjects living in towns and towns, and their vitamin D deficiency rate and lack rate were significantly lower than those in urban areas. 6. according to the blood sampling time of the subjects, the levels of serum 25 (OH) D in different months of blood sampling, and the difference between the deficiency rate and the deficiency rate of vitamin D were significantly different. The levels of serum 25 (OH) D in the third quarter (July, August, September) were significantly higher than those of other quarterly blood sampling samples, while their vitamin D deficiency and deficiency rates were significantly lower than those of other quarterly blood sampling samples; 7. multivariate linear regression and Logistic regression analysis showed that the sex of the research subjects was living in the coastal areas. There was no significant correlation between the level of serum 25 (OH) D. The age, occupation, or living in the town, the blood sampling time of the sample was related to the level of serum 25 (OH) D, age, occupation, whether living in the town, and the sampling time was the main factor affecting the deficiency and deficiency of vitamin D in the population. Conclusion 1. serum of Han Adults in Shandong Province The average level of 25 (OH) D is generally low, the average level is 14.25 + 8.23, 94.1% of the individuals in the population are in the deficiency state of vitamin D, and 78.5% of the individual vitamin D is in a lack state; 2. the nutritional status of vitamin D in the Han Adults in Shandong Province has a significant correlation with the age of the subjects, the occupation, whether living in the countryside, and the sampling time. The risk factors for the gender, whether living in the coastal areas without significant correlation of.3. vitamin D deficiency are: (1) 30 years old and below women and older people over 70 years of age (2) civil servants, cadres, students and teachers (3) for a long time in urban areas
【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R580

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