本文選題：骨質(zhì)疏松 + 牙槽骨��； 參考：《中國骨質(zhì)疏松雜志》2017年09期

【摘要】：目的探究骨質(zhì)疏松患者血清鈣、磷、骨堿性磷酸酶代謝變化及其與牙槽骨骨密度的相關(guān)性,以期通過血生化指標(biāo)了解牙槽骨的代謝狀況。方法 46例患者隨機(jī)分為2組,觀察組(強(qiáng)骨膠囊組)和對照組(阿侖膦酸鈉片組)各23例,藥物治療前采集靜脈血進(jìn)行血清鈣、磷、骨堿性磷酸酶水平檢測,并行錐形束CT檢查,測量牙槽骨骨密度,藥物治療后6月時重復(fù)以上檢測和檢查,觀察血清鈣、磷、骨堿性磷酸酶變化情況,分析以上血生化指標(biāo)與牙槽骨骨密度的相關(guān)關(guān)系。結(jié)果藥物治療前及藥物治療后6月觀察組和對照組血清鈣、磷及骨堿性磷酸酶變化組間比較均無統(tǒng)計學(xué)意義(P0.05)。藥物治療前及藥物治療后6月觀察組和對照組血清鈣、磷變化與牙槽骨骨密度無統(tǒng)計學(xué)相關(guān)性(P0.05)。藥物治療前觀察組和對照組BALP與牙槽骨頰(唇)側(cè)皮質(zhì)骨骨密度變化呈負(fù)相關(guān)(r=-0.440,P0.05;r=-0.419,P0.05),藥物治療后6月兩組BALP與牙槽骨頰(唇)側(cè)皮質(zhì)骨骨密度亦呈負(fù)相關(guān)(r=-0.642,P0.05;r=-0.442,P0.05)。結(jié)論 (1)血清BALP與牙槽骨頰(唇)側(cè)皮質(zhì)骨BMD呈統(tǒng)計學(xué)負(fù)相關(guān);(2)強(qiáng)骨膠囊可用以提高合并牙列缺損或缺失的骨質(zhì)疏松患者牙槽骨骨密度;(3)血清骨堿性磷酸酶可作為評估合并牙列缺損或缺失的骨質(zhì)疏松患者牙槽骨頰(唇)側(cè)皮質(zhì)骨骨密度變化的參考指標(biāo)。
[Abstract]:Objective to investigate the changes of serum calcium, phosphorus, bone alkaline phosphatase metabolism and their correlation with alveolar bone mineral density (BMD) in patients with osteoporosis. Methods Forty-six patients were randomly divided into two groups: the observation group (Qianggu capsule group) and the control group (alendronate sodium tablet group, 23 cases). The serum calcium, phosphorus and bone alkaline phosphatase levels were measured before treatment. The bone mineral density of alveolar bone was measured by conical beam CT. The changes of serum calcium, phosphorus and bone alkaline phosphatase were observed at 6 months after drug treatment, and the correlation between the above blood biochemical indexes and alveolar bone mineral density was analyzed. Results there was no significant difference in serum calcium, phosphorus and bone alkaline phosphatase (BALP) between the observation group and the control group before and 6 months after drug treatment (P 0.05). There was no significant correlation between the changes of serum calcium and phosphorus and alveolar bone mineral density (BMD) in the observation group and the control group before and 6 months after drug treatment. There was a negative correlation between BALP and BMD of buccal (labial) side of alveolar bone in observation group and control group before and after drug treatment. There was also a negative correlation between BALP and BMD of buccal (labial) side of alveolar bone in both groups at 6 months after drug treatment, and there was also a negative correlation between BALP and BMD of buccal (labial) side of alveolar bone (lip). Conclusion (1) Serum BALP is negatively correlated with BMD of buccal (labial) side of alveolar bone. Qianggu capsule can be used to increase alveolar bone mineral density in patients with osteoporosis complicated with dentition defect or missing. To evaluate the change of bone mineral density of alveolar bone in patients with osteoporosis complicated with dentition defect or loss.
【作者單位】： 徐州醫(yī)科大學(xué)口腔醫(yī)學(xué)院;徐州醫(yī)科大學(xué)附屬醫(yī)院口腔科;
【基金】：徐州市科技計劃項目(KC14SH082) 江蘇省自然科學(xué)基金項目面上項目(BK20141141) 徐州醫(yī)科大學(xué)校級科研課題(2015KJ06)
【分類號】：R580

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