本文選題：型糖尿病 + 血清抵抗素��； 參考：《中國臨床藥理學雜志》2017年04期

【摘要】：目的研究2型糖尿病患者血清抵抗素、瘦素、脂聯(lián)素水平與頸動脈內中膜厚度及斑塊穩(wěn)定性的關系。方法納入2型糖尿病患者60例、糖耐量異�；颊�50例、健康體檢人群50例,用酶聯(lián)免疫吸附試驗(ELISA)法檢測血清抵抗素、瘦素、脂聯(lián)素水平,并檢測頸動脈內中膜厚度(IMT)及斑塊形成率。結果耐糖量異常、2型糖尿病患者血清抵抗素水平分別為(3.26±1.85),(4.61±2.08)ng·mL~(-1),瘦素水平分別為(1.83±0.09),(3.10±0.15)ng·mL~(-1)、脂聯(lián)素水平分別為(3.57±0.11),(1.61±0.12)μg·mL~(-1)、IMT分別為(1.15±0.04),(1.59±0.12)mm,頸動脈斑塊檢出率分別為10.00%(5/50例)和51.67%(31/60例),差異均有統(tǒng)計學意義(P0.05);2型糖尿病患者中無斑塊組、穩(wěn)定性斑塊組及不穩(wěn)定斑塊組血清抵抗素水平分別為(3.01±1.25),(4.17±1.08),(5.35±1.16)ng·mL~(-1)、瘦素水平分別為(1.33±0.15),(2.21±0.12),(3.15±0.17)ng·mL~(-1),而脂聯(lián)素水平分別為(2.81±0.10),(1.95±0.09),(1.14±0.12)μg·mL~(-1),差異均有統(tǒng)計學意義(P0.05);血清抵抗素與瘦素呈正相關(P0.01),二者與APN水平均呈負相關(P0.01)。結論 2型糖尿病患者血清抵抗素、瘦素水平升高、脂聯(lián)素水平降低與頸動脈內中膜厚度增厚、斑塊形成及穩(wěn)定性密切相關。
[Abstract]:Objective to study the relationship between serum resistin leptin adiponectin and carotid intima media thickness and plaque stability in patients with type 2 diabetes. Methods Serum resistin, leptin and adiponectin levels were detected by Elisa in 60 patients with type 2 diabetes, 50 patients with impaired glucose tolerance and 50 healthy controls. Carotid intima-media thickness (IMT) and plaque formation rate were measured. 緇撴灉鑰愮硸閲忓紓甯，

本文編號：1979334