本文選題：絕經后骨質疏松癥 + 抗酒石酸酸性磷酸酶-b　； 參考：《山東醫(yī)藥》2017年35期

【摘要】：目的觀察絕經后骨質疏松癥(PMOP)患者血清抗酒石酸酸性磷酸酶-5b(TRACP-5b)、同型半胱氨酸(Hcy)、骨源性堿性磷酸酶(BAP)水平變化,并探討其臨床意義。方法將138例絕經后女性按骨密檢查結果分為PMOP組(骨密度低于-2.5)39例、骨密度降低組(骨密度-2.5~-1.0)51例、骨密度正常組(骨密度-1.0~1.0)48例。檢測各組血清TRACP-5b、Hcy、BAP水平,采用偏相關性分析法分析PMOP組患者血清TRACP-5b、Hcy、BAP水平的相關性。繪制血清TRACP-5b、Hcy、BAP水平診斷PMOP的受試者工作曲線(ROC曲線),計算曲線下面積,采用最大約登指數法確定血清TRACP-5b、Hcy、BAP水平診斷PMOP的截斷值。結果 PMOP組血清TRACP-5b、Hcy、BAP水平均高于骨密度降低組和骨密度正常組(P均0.05),骨密度降低組血清TRACP-5b、Hcy、BAP水平均高于骨密度正常組(P均0.05)。偏相關分析結果顯示觀察組血清Hcy水平與血清TRACP-5b水平呈正相關(r=0.728,P0.05),與血清BAP水平呈正相關(r=0.691,P0.05);血清TRACP-5b水平與血清BAP水平呈正相關(r=0.653,P0.05)。血清TRACP-5b、Hcy、BAP水平診斷PMOP的ROC曲線下面積分別為0.728、0.717、0.695,截斷值分別為3.43 U/L、17.85μg/L、23.38 mmol/L。結論 PMOP患者血清TRACP-5b、BAP、Hcy水平升高。臨床上可以用血清TRACP-5b、BAP、Hcy輔助診斷PMOP。
[Abstract]:Objective to observe the changes of serum antitartrate acid phosphatase -5bAP-5b, homocysteine, bone alkaline phosphatase (BAP) in patients with postmenopausal osteoporosis (PMOP) and to explore its clinical significance. Methods according to bone density, 138 postmenopausal women were divided into PMOP group (BMD < -2.5), BMD decreased group (BMD -2.5 + -1.0) and normal BMD group (BMD -1.0) in 48 cases. The levels of serum TRACP-5bHcyAP-BAP were detected in each group, and the correlation of serum TRACP-5bHcyAP-BAP levels in patients with PMOP was analyzed by partial correlation analysis. The operating curve of PMOP was drawn and the area under the curve was calculated. The truncation value of serum TRACP-5 BAP for diagnosis of PMOP was determined by the method of maximum Jordan index. Results the serum levels of TRACP-5bHcyhcyBAP in PMOP group were higher than those in BMD decreased group and normal BMD group (P 0.05), and the levels of serum TRACP-5 BAP in BMD decreased group were higher than those in BMD normal group (P 0.05). The results of partial correlation analysis showed that the serum Hcy level was positively correlated with the serum TRACP-5b level, the serum BAP level was positively correlated with the serum BAP level, and the serum TRACP-5b level was positively correlated with the serum BAP level. The area under the ROC curve of serum TRACP-5 BAP for PMOP diagnosis was 0.728 / 0.717 / 0.695, and the truncation value was 3.43 U / L / L 17.85 渭 g / L ~ (23.38) mmol 路L ~ (-1) 路L ~ (-1), respectively. Conclusion the level of serum TRACP-5 BAPP Hcy in patients with PMOP is increased. Serum TRACP-5 BAPHcy can be used to assist the diagnosis of PMOP.
【作者單位】： 貴州省骨科醫(yī)院;
【基金】：貴州省衛(wèi)生廳科研計劃項目(201510003524)
【分類號】：R580

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