本文選題：代謝綜合征 + 腎細胞癌�。� 參考：《中華腫瘤防治雜志》2017年06期

【摘要】：目的代謝綜合征(metabolic syndrome,MS)是一組臨床癥候群,MS及其相關組分與癌癥發(fā)生發(fā)展及病理特征具有密切關系。本研究旨在分析MS及其相關組分與腎透明細胞癌(clear cell cenal cell carcinoma,CCRCC)分期、分級及腫瘤大小的相關性。方法回顧性分析2013-01-01-2015-12-30于山西醫(yī)科大學第一醫(yī)院就診且病理診斷為CCRCC的375例患者的臨床資料,包括年齡、性別、身高、體質量、血壓、空腹血糖、生化結果、病理分期分級和腫瘤大小等。計數(shù)資料采用χ2檢驗,計量資料以x-±s表示,組間比較采用t檢驗,多因素分析采用Logistic回歸分析。結果 MS組56例患者,其中男性患者32例,女性患者24例;非MS組319例患者,其中男性患者206例,女性患者113例。男女患者比較,差異無統(tǒng)計學意義,P=0.287。MS組與非MS組相比,年齡、吸煙、飲酒等差異無統(tǒng)計學意義,P值分別為0.100、0.691和0.269;而BMI指數(shù)、收縮壓、空腹血糖、TG、HDL-C等差異均有統(tǒng)計學意義,均P0.001。在病理特點方面,MS與非MS相比,CCRCC病理分期(P=0.018)、分級(P=0.026)及腫瘤大小(P=0.026),差異均有統(tǒng)計學意義。MS相關疾病與CCRCC分期分析,糖尿病(P0.001)、高血壓(P=0.015)、血脂紊亂(P=0.006)與CCRCC的分期有關。結論 CCRCC合并MS者病理分期較高、分級較低、腫瘤更大,糖尿病、高血壓和血脂紊亂都可增加CCRCC的病理分期。
[Abstract]:Objective Metabolic syndromes (MS) is a group of clinical syndromes MS and its related components are closely related to the occurrence and development of cancer and pathological features. The purpose of this study was to analyze the correlation between MS and its components in clear cell cenal cell carcinoma (CCRC) stage, grade and tumor size. Methods the clinical data of 375 patients with CCRCC, including age, sex, height, body weight, blood pressure, fasting blood glucose, biochemical results, were retrospectively analyzed. Pathological staging and tumor size. The counting data were analyzed by 蠂 2 test, the measurement data were expressed as x- 鹵s, the comparison between groups was t test, and the Logistic regression analysis was used in multivariate analysis. Results there were 56 patients in MS group, including 32 males and 24 females, and 319 patients in non-MS group, including 206 males and 113 females. There was no significant difference in age, smoking and drinking between male and female patients (P < 0.01), but there were significant differences in BMI index, systolic blood pressure, fasting blood glucose and HDL-C between the two groups (P 0.001). The pathological features of MS were compared with those of non-MS. The pathological stages of CCRCC were P0.018, P0.026) and the size of tumor was 0.026. The difference was statistically significant. The differences of MS-related diseases and CCRCC staging were statistically significant. Diabetes mellitus P0.001, Hypertension 0.015D, dyslipidemia P0.006) were related to the staging of CCRCC. Conclusion the pathological stage of CCRCC complicated with MS is higher, lower grade, larger tumor, diabetes, hypertension and dyslipidemia can increase the pathological staging of CCRCC.
【作者單位】： 山西醫(yī)科大學第一醫(yī)院泌尿外科;
【分類號】：R589;R737.11

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