發(fā)布時間：2018-05-29 15:53

  本文選題：急性腦梗死 + 高尿酸血癥��； 參考：《山東醫(yī)藥》2017年28期

【摘要】：目的探討伴高尿酸血癥的急性腦梗死患者血尿酸水平與預后的關(guān)系。方法選擇伴高尿酸血癥的急性腦梗死患者119例(尿酸升高組),其中60例接受降尿酸治療、59例未接受降尿酸治療,另選血尿酸水平正常的急性腦梗死患者88例(尿酸正常組)。兩組入院后均予急性腦梗死常規(guī)治療,尿酸升高組中60例在此基礎上接受降尿酸治療。分別于入院時,治療1、2周及治療3個月,檢測接受或未接受降尿酸治療者血尿酸水平。入院時及治療1、2周,采用美國國立衛(wèi)生研究卒中量表(NIHSS)評分評價腦梗死急性期神經(jīng)功能損害程度。入院時、治療3個月,采用改良PANKIN量表(MRS)評分評價腦梗死恢復期神經(jīng)功能損害程度。以MRS評分≤2分為預后良好、MRS評分2分為預后不良,比較二者治療3個月的預后情況。結(jié)果接受與未接受降尿酸治療者入院時、治療1周血尿酸水平比較P均0.05;接受降尿酸治療者降尿酸治療2周及治療3個月血尿酸水平明顯低于未接受降尿酸治療者(P均0.05)。接受降尿酸治療者隨治療時間延長,血尿酸水平逐漸降低(P0.05)。兩組治療前NIHSS、MRS評分比較P均0.05。尿酸升高組未接受降尿酸治療者治療1、2周NIHSS評分明顯高于尿酸升高組接受降尿酸治療者及尿酸正常組(P均0.05),治療3個月MRS評分明顯高于尿酸升高組接受降尿酸治療者及尿酸正常組(P均0.05),而尿酸正常組與尿酸升高組接受降尿酸治療者同期NIHSS、MRS評分比較P均0.05。治療3個月,尿酸升高組未接受降尿酸治療者預后良好率明顯低于尿酸升高組接受降尿酸治療者及尿酸正常組(P均0.05),而尿酸正常組與尿酸升高組接受降尿酸治療者預后良好率比較差異無統(tǒng)計學意義(P0.05)。結(jié)論伴高尿酸血癥的急性腦梗死患者預后較差,降尿酸治療可改善患者預后。
[Abstract]:Objective to investigate the relationship between serum uric acid level and prognosis in patients with acute cerebral infarction with hyperuricemia. Methods 119 patients with acute cerebral infarction with hyperuricemia were selected. Among them, 60 patients were treated with hypouric acid and 59 patients were not treated with hypouric acid. 88 patients with acute cerebral infarction with normal serum uric acid level were selected. Both groups were treated with routine treatment of acute cerebral infarction after admission, 60 cases of patients with elevated uric acid were treated with hypouric acid on this basis. The serum uric acid levels were measured at admission, 1 ~ 2 weeks and 3 months respectively. At admission and 1 to 2 weeks of treatment, the NIH scale was used to evaluate the degree of neurological impairment in acute cerebral infarction. After 3 months of treatment, modified PANKIN scale was used to evaluate the degree of neurological impairment in convalescent stage of cerebral infarction. According to MRS score 鈮，

本文編號：1951452