本文選題：急性痛風性關(guān)節(jié)炎 + 濕熱夾瘀　； 參考：《廣州中醫(yī)藥大學》2016年碩士論文

【摘要】：目的：通過隨機對照的方法,比較臨床癥狀、實驗室檢查變化,觀察并評價痛風方聯(lián)合西藥在治療急性痛風性關(guān)節(jié)炎的臨床療效及安全性,探索中西藥結(jié)合治療對于控制急性期癥狀的優(yōu)勢。方法：選擇符合納入標準,中醫(yī)證型屬濕熱夾瘀的急性痛風性關(guān)節(jié)炎患者60例,按隨機數(shù)字表法隨機分組,分為治療組和對照組,各30例。治療組予口服依托考昔片、秋水仙堿片、非布司他片加上痛風方,對照組予口服依托考昔片、秋水仙堿片、非布司他片；兩組觀察期均為7天。記錄并分析治療前后患者中醫(yī)證候積分、臨床癥狀的改變,血尿酸(UA)、血清C反應蛋白(CRP)、血沉(ESR)、肝腎功能(天門冬氨酸轉(zhuǎn)氨酶AST、丙氨酸氨基轉(zhuǎn)氨酶ALT、尿素UREA、肌酐CREA)測定的變化及不良反應。結(jié)果：治療組與對照組中醫(yī)療效總有效率分別為100%和90%,治療后兩組的中醫(yī)證候、關(guān)節(jié)疼痛均有緩解(P0.05),且治療組的改善更顯著；治療后兩組UA、CRP、ESR均下降(P0.05),且治療組UA及CRP下降優(yōu)于對照組；治療后兩組三大常規(guī)(血分析、尿組合、大便檢查)及肝腎功能均未出現(xiàn)嚴重影響。結(jié)論：從臨床觀察及數(shù)據(jù)分析,得出兩組均能改善中醫(yī)證候、關(guān)節(jié)疼痛,且降低UA、CRP、ESR,治療組在緩解中醫(yī)證候和關(guān)節(jié)疼痛具有更明顯優(yōu)勢,UA、CRP下降速度更快,故說明中西藥結(jié)合治療急性痛風性關(guān)節(jié)炎療效優(yōu)于單純西藥治療。
[Abstract]:Objective: to observe and evaluate the clinical efficacy and safety of gout prescription combined with western medicine in the treatment of acute gouty arthritis. To explore the advantages of the combination of traditional Chinese and western medicine in the control of acute symptoms. Methods: sixty cases of acute gouty arthritis with dampness heat and stasis were selected and divided randomly into treatment group and control group with 30 cases each. The treatment group was treated with oral topoxime tablet, colchicine tablet, non-busulta tablet plus gout prescription, while the control group was given etacoxib tablet, colchicine tablet, and non-busulta tablet. The observation period of both groups was 7 days. To record and analyze the scores of TCM syndromes and the changes of clinical symptoms of patients before and after treatment. Changes and adverse reactions of serum C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), liver and kidney function (aspartate aminotransferase AST, alanine aminotransferase alt, urea UREAA, creatinine). Results: the total effective rate of TCM in treatment group and control group was 100% and 90%, respectively. After treatment, the TCM syndromes and joint pain in both groups were relieved (P 0.05), and the improvement of treatment group was more significant. The levels of UA and CRP in the treatment group were lower than those in the control group, and the three major routine (blood analysis, urine combination, stool examination) and liver and kidney function were not seriously affected after treatment. Conclusion: from clinical observation and data analysis, it is concluded that both groups can improve TCM syndromes, joint pain, and reduce UACRP ESR.The treatment group has more obvious advantages in relieving TCM syndromes and joint pain. Therefore, the combination of traditional Chinese medicine and western medicine is superior to western medicine in the treatment of acute gouty arthritis.
【學位授予單位】：廣州中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R589.7

【引證文獻】

相關(guān)期刊論文 前1條

1 丁寧;;低分子肝素鈣治療慢性阻塞性肺炎的效果及劑量分析[J];臨床醫(yī)藥文獻電子雜志;2017年39期

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