本文選題：型糖尿病 + 桑酮堿　； 參考：《中成藥》2017年01期

【摘要】：目的觀察桑酮堿對2型糖尿病大鼠糖脂代謝、胰島素抵抗、脂肪細胞因子的影響及其作用機制。方法 140只大鼠喂以高脂飼料聯(lián)合鏈脲佐菌素(STZ)建立2型糖尿病模型,空腹血糖值16.7 mmol/L,大鼠隨機分為模型組、二甲雙胍(180 mg/kg)組、桑酮堿(73.5、147、294 mg/kg)組,空白組10只,治療組灌胃給藥12周。給藥后每2周測定大鼠空腹血糖(FBG);給藥12周后,測定糖化血清蛋白(GSP)、糖化血紅蛋白(GHb)及血脂指標(TC、TG、HDL-C、LDL-C);放免法測定血清胰島素水平,并計算胰島素抵抗指數(shù)(HOMR-IR)和胰島素敏感指數(shù)(ISI);酶聯(lián)免疫吸附實驗(ELISA)測定血清脂聯(lián)素和瘦素水平。結(jié)果桑酮堿顯著降低2型糖尿病大鼠的空腹血糖、GSP、GHb、TC、TG、LDL-C、瘦素水平和胰島素抵抗指數(shù),升高HDL-C、脂聯(lián)素水平和胰島素敏感指數(shù)。結(jié)論桑酮堿能改善2型糖尿病大鼠糖脂代謝,是通過改善胰島素抵抗和調(diào)節(jié)脂肪細胞因子水平而成的。
[Abstract]:Objective to observe the effects of carnitine on glucose and lipid metabolism, insulin resistance and adipocyte factor in type 2 diabetic rats. Methods 140 rats were fed with high fat diet combined with streptozotocin (STZ) to establish type 2 diabetic model. The fasting blood glucose value was 16.7 mmol / L. The rats were randomly divided into model group, metformin 180 mg / kg group, mulberry alkaloid 73.5147 294 mg / kg group and blank group (10 rats). The treatment group was given intragastric administration for 12 weeks. The fasting blood glucose (FBGG) was measured every 2 weeks after administration, the glycosylated serum protein (GSPN), glycosylated hemoglobin (GHB) and serum lipids were measured 12 weeks after administration, and the serum insulin level was measured by radioimmunoassay. The insulin resistance index (HOMR-IRI) and insulin sensitivity index (ISI) were calculated, and the serum adiponectin and leptin levels were measured by Elisa. Results the levels of leptin, insulin resistance, HDL-C, adiponectin and insulin sensitivity index were significantly decreased in type 2 diabetic rats. Conclusion Mulberry alkaloids can improve glucose and lipid metabolism in type 2 diabetic rats by improving insulin resistance and regulating the level of adipocyte cytokines.
【作者單位】： 南京中醫(yī)藥大學(xué)藥學(xué)院;江蘇省中藥資源產(chǎn)業(yè)化過程協(xié)同創(chuàng)新中心;江蘇大學(xué)藥學(xué)院;江蘇省中藥藥效與安全性評價重點實驗室;
【基金】：國家自然科學(xué)基金(81072985,81573529,81373980) 江蘇高校優(yōu)勢學(xué)科建設(shè)工程資助項目(PAPD)
【分類號】：R587.1

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